In 2007, the National Institute of Environmental Health Sciences launched a program of new research centers called Disease Investigation through Specialized Clinically Oriented Ventures in Environmental Research (DISCOVER).
The University of Washington's DISCOVER center studies the mechanistic relationship between cardiovascular disease and traffic related air pollution. The study is composed of five closely linked projects that explore this relationship through a diverse set of research approaches. Our ultimate mission is to transfer the findings of the center rapidly into the development of improved clinical and public health practice.
- Center Leadership Team
- Center Director: Joel Kaufman, MD, MPH
Deputy Director: Michael Rosenfeld, PhD
Associate Director/Lead Physician-Scientist: David Siscovick, MD, MPH
Assistant Director for Communication/Translation: Edward Gill, MD
Center Manager: Meghann Seiler
- Project 1
Vascular Response to Diesel Exhaust in Humans
- Director: Joel Kaufman, MD, MPH
Co-Investigator: Edward Gill, MD
- Project 2
Cardiovascular Diseases and Traffic in a Multi-Ethnic Cohort: Gene Effects
- Director: Sverre Vedal, MD, MSc
Co-Investigators:
Joel Kaufman, MD, MPH
Lianne Sheppard, PhD, MSc
Richard Kronmal, PhD
Sara Adar, MHS, ScD
- Project 3
Diesel Exhaust, Vascular Response, and Systemic Inflammation
- Director: Kanchan Chitaley, PhD
Co-Investigators:
Francis Kim, MD
Stephan van Eeden, MD, PhD
- Project 4
Myocardial Injury and Apoptosis with Diesel Exhaust Exposure
- Director: Michael Chin, MD, PhD
- Project 5
Reactive Oxygen Species, Glutathione and Vascular Response to Diesel Exhaust
- Director: Terry Kavanagh, PhD, MS
Co-Investigators:
Michael Rosenfeld, PhD
Daniel Luchtel, PhD
Stephen Schwartz, MD, PhD
- Expsoure Science, Charaterization, and Generation Core
- Director: Timothy Larson, PhD, MSChE
- Biostatistics and Bioinformatics Core
- Director: Lianne Sheppard, PhD, MSc
Co-Investigators:
Paul Sampson, PhD
Adam Szpiro, PhD
Jon Wakefield, PhD
Kathleen Kerr, PhD
- University of Washington Scientific Advisory Committee
- David Dichek, MD
David Eaton, PhD, DABT
Eric Feigl, MD
Renee LeBoeuf, PhD
Joellen Lewtas, PhD
Debbie Nickerson, PhD
Bruce Psaty, MD, PhD
Nora Disis, MD, MS