- Project 2
Cardiovascular Diseases and Traffic in a Multi-Ethnic Cohort: Gene Effects
- The overall aim of this project is to gain insight into the inflammatory, oxidative and endothelial control mechanisms underlying the cardiovascular effects of short- and long-term exposure to traffic-associated fine particulate matter (PM). This will be accomplished by investigating in a human population the differential susceptibility to PM effects associated with specific genetic polymorphisms that involve these key mechanistic pathways.
The aim will be addressed by making efficient use of an ongoing cohort study of atherosclerotic cardiovascular disease, the Multi-ethnic Study of Atherosclerosis (MESA), and several MESA ancillary studies for which PM and traffic exposure data, genotyping data, and data on multiple relevant cardiovascular endpoints are being collected.
Director: Sverre Vedal, MD, MSc
Joel Kaufman, MD, MPH
Lianne Sheppard, PhD, MSc
Richard Kronmal, PhD
Sara Adar, MHS, ScD