Quellos High Throughput Screening Core
ABOUT THE CORE
The Quellos High Throughput Screening Core is located within the UW's Institute for Stem Cell and Regenerative Medicine at UW Medicine's new biotechnology and medical research hub in the South Lake Union area of Seattle. Serving academia, biotechnology and bio-pharma organizations across the region, this academic center specialize in RNA Inhibition and Small Molecule Screening technologies. The HTS Core's instrumentation and BSL-2 certified cell culture facility is housed in approximately 1,500 sq ft of the nearly 274,000 sq ft UW research laboratory space that's spread among three buildings at the site. Experienced, trained personnel are available to aid clients in their assay optimization and screening activities. As a one of a kind facility in the Seattle area, the Quellos High Throughput Screening Core was created to provide clients the best approaches that Biotechnology and large Pharmaceutical organizations have to offer.
TYPE OF SCREENS DONE
High Throughput Screening (HTS) has revolutionized the way biomedical research can be conducted in the last several years. Utilizing laboratory automation and robotics, HTS has enabled scientists to study complex biological systems and identify therapeutic drug candidates in reasonable timeframes that previously were improbable. Formerly the sole domain of large pharmaceutical companies, HTS centers have been built at major research centers across the United States. Currently, lack of an academic HTS center in the Pacific Northwest was recently remedied by a philanthropic gift of capital thereby creating the Quellos High Throughput Screening Core within the Institute for Stem Cell and Regenerative Medicine at the University of Washington in Seattle, WA. It is the goal of this HTS facility to provide the best approaches that Biotech and Big Pharma have to offer. Targeting genomic screening paradigms (RNA Interference, RNAi) will aid the determination of gene function and generate potential targets for drug discovery activities. HTS of chemical (small molecule) libraries against cells or classical targets will generate drug leads that can be further optimized for "first-in-man" clinical studies. Hence, this UW core facility can provide both target validation and drug discovery/optimization processes.
Instrumentation and Analysis
The center currently houses and offers training and assay development on:
Cybio CyBi-Well Vario Liquid Handler
PerkinElmer EnVision Multi-Label Detector
Matrix WellMate Dispenser
For more information on equipment click here
Data analysis and report generation utilizing the following:
Microsoft Office Suite
ChemBioOffice Ultra by CambridgeSoft
XLFit by idbs
Miner3D
Experience:
The HTS Core's staff exhibits over 25 years of combined experience in the Biotechnology and Pharmaceutical Industry.
For more information on RNA Interference screening click here.
For more information on small molecule screening click here.
CONTACT US
For more information about the Quellos High Throughput Screening Core click here.
