Leadership Staff
Jairam Lingappa, MD, PhD
Associate Director, International Clinical Research Center
Associate Professor of Global Health and Medicine
Adjunct Associate Professor of Pediatrics
Co-Director of CFAR Repository
Curriculum Vitae: PDF
Research Interests:
Dr. Lingappa’s research focuses on using clinical research studies to better understand host defense factors in infectious diseases. Currently he is medical director and co-investigator of a large mult-isite clinical trial in Africa evaluating suppression of genital herpes (HSV-2) to reduce HIV transmission; and co-investigator on a second large multi-site clinical trial of pre-exposure antiretroviral prophylaxis to reduce HIV transmission.
Epidemiologic data and clinical specimens from these and other clinical studies are stored in the UW Department of Global Health International Clinical Research Center (ICRC). Collaborating with specialty immunology and genomics labs at the UW and elsewhere, Dr. Lingappa uses these specimens and data to conduct translational scientific investigations into the role of host genomic and immunologic factors and viral co-infections on HIV and other infections.
Selected publications:
- Lingappa, J.R., Lambdin, B., Bukusi, B. et al for the Partners HSV-2 Study Group. Prevalence of HIV-1 Discordance in Eastern and Southern Africa and Impact on Enrollment into an HIV-1 Prevention Clinical Trial, PLoS ONE, 2008, Jan 9, 3(1), e1411
- Lingappa J and Celum C. Clinical and Therapeutic Issues for HSV-2 and HIV Co-Infection. Drugs 2007, 67(2):155-74
- Tong S, Lingappa JR, Chen Q, et al., Direct sequencing of SARS-coronavirus S and N genes from clinical specimens shows limited variation. J Infect Dis 2004 Sep 15; 190(6):1127-31. Epub 2004 Aug 17.
- Lingappa J, Kuffner T, Tappero J,. et al. HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of Leptospirosis. Genes Immun. 2004 May; 5(3):197-202.
- Lingappa JR, McDonald LC, Simone P, Parashar UD. Wresting SARS from uncertainty. Emerg Infect Dis 2004 Feb; 10(2):167-70.
- Keeler N and Lingappa J. Severe acute respiratory syndrome: public health response and clinical practice update for an emerging disease. Curr Opin Pediatr February 2004; 16(1):61-9.
- Agrawal A, Lingappa J, Leppla SH, et al. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature 2003 Jul 17; 424(6946): 329-34.
- Lingappa JR, Al-Rabeah AM, Hajjeh R. et al., Serogroup W-135 Meningococcal Disease during the Hajj, 2000. Emerg. Inf. Dis. J 2003; 9(6): 665-71.
- Pulendran B , Lingappa J, Kennedy M,. et al. Developmental pathways of dendritic cells in vivo: distinct function, phenotypes and localization of dendritic cell subsets in FLT3-ligand treated mice. Journal of Immunology 1998; 159, 2222-31.