By providing a number of Core Facilities, the NORC facilitates the integration and coordination of the abundant ongoing activities throughout the UW system. Our overarching goals are to foster new interdisciplinary research collaborations, stimulate new research activities, improve nutrition and obesity education at multiple levels, and facilitate optimal nutritional management of patients.

Core facilities are available for use by Affiliate Investigators, who are broadly dispersed throughout several schools and numerous departments and divisions within the University of Washington.

The University of Washington NORC is supported by the National Institutes of Health, NIDDK, grant # P30 DK035816. Please cite this grant support in your publications if you have utilized NORC facilities for the research.

Recent Publications

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans.

Melhorn SJ, Tyagi V, Smeraglio A, Roth CL, Schur EA. Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite 82:85-90, 2014. PMCID: PMC4171349

Control of hepatic glucose metabolism by islet and brain.

Rojas JM, Schwartz MW. Control of hepatic glucose metabolism by islet and brain. Diabetes Obes Metab 1:33-40, 2014. PMCID: PMC4191916

Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.

den Hartigh LJ, Wang S, Goodspeed L, Ding Y, Averill M, Subramanian S, Wietecha T, O'Brien KD, Chait A. Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice. PLoS One, 2014. PMCID: PMC4177399

Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology 155:3409-20, 2014. PMCID: PMC4138576

Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study.

Berkseth KE, Guyenet SJ, Melhorn SJ, Lee D, Thaler JP, Schur EA, Schwartz MW. Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology 155:2858-67, 2014. PMCID: PMC4098007

Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.

Spiezio SH, Amon LM, McMillen TS, Vick CM, Houston BA, Caldwell M, Ogimoto K, Morton GJ, Kirk EA, Schwartz MW, Nadeau JH, LeBoeuf RC. Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mammalian Genome 2014 Jul 8 [Epub ahead of print]

Upcoming Seminars

12/03


Karin Bornfeldt, PhD University of Washington

Diabetes and Atherosclerosis – What Have We Learnt From Mice and Humans?

12/17


Raghu Mirmira, MD, PhD Indiana University

Islet β Cell Dysfunction in Diabetes: Too Much Hyp(e)?

01/07


Type 1 Diabetes and Immunology Half Day Symposium

Poll Lecture : Kevin Herold, MD, Yale University

02/04


Per-Henrik Groop, MD Helsinki University Central Hospital

Diabetic Nephropathy – Genes or the Environment?

02/18


Steven Kahn, MB, ChB University of Washington, VA Puget Sound Health Care System

The Beta Cell in Type 2 Diabetes: Lessons Starting at the Bedside

02/25


Alvin Powers, MD Vanderbilt University

Pancreatic Islets: Their Role in Type 1 and Type 2 Diabetes