Recent Publications

Publications & Core Use/P&F Awards

2013

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, Gudnason V, Harris TB, Kathiresan S, Kraaij R, Launer LJ, Levy D, Liu Y, Mosley T, Peloso GM, Psaty BM, Rich SS, Rivadeneira F, Siscovick DS, Smith AV, Uitterlinden A, van Duijn CM, Wilson JG, O'Donnell CJ, Rotter JI, Boerwinkle E: Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. Plos One 8:e68095, 2013. PMCID: PMC3709915 Analytic Core

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, Den Hartigh LJ, Averill MM, O'Brien KD, Ledbetter J, Chait A: T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice. Plos One 8:e67709, 2013. PMCID: PMC3699637 Adipose Tissue Lipid Biology Core

Schwartz MW, Baskin DG: Leptin and the brain: then and now. J Clin Invest 123:2344-2345, 2013. PMCID: PMC3668840 Energy Balance Glucose Metabolism Core

Berkseth K, Schur E, Schwartz MW:  A role for natriuretic peptides in the central control of energy balance? Diabetes 62:1379-1381, 2013. (Review). PMCID: PMC3636633 Energy Balance Glucose Metabolism Core

Toriola AT, Cheng TY, Neuhouser ML, Wener MH, Zheng Y, Brown E, Miller JW, Song X, Beresford SA, Gunter MJ, Caudill MA, Ulrich CM: Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. Int J Cancer 132:2648-58, 2013. PMCID: PMC3609926 Analytic Core

Lee D, Thaler JP, Berkseth K, Melhorn SJ, Schwartz MW, Schur EA:  Longer T2 relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. Am J Physiol Endocrinol Metab 304:E1245-1250, 2013. PMCID: PMC3680680 Energy Balance Glucose Metabolism Core, P&F Award (Thaler)

Smits MM, Woudstra P, Utzschneider KM, Tong J, Gerchman F, Faulenbach M, Carr DB, Aston-Mourney K, Chait A, Knopp RH, Meigs JB, Boyko EJ, Kahn SE: Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis. Ann Epidemiol 23:415-421, 2013.  PMCID: PMC3778191 Human Studies Core (discontinued Core)

Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM: Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 288:10722-10735, 2013. PMCID: PMC3624452 Energy Balance Glucose Metabolism Core

Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek TH, Ogimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ:  In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Am J Physiol Endo Metab 304:E734-746, 2013. PMCID: PMC3625754 Energy Balance Glucose Metabolism Core

Guyenet SI, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP:  High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Res 1512:97-105, 2013.  PMCID:  PMC3685737 Energy Balance Glucose Metabolism Core

Sachs MC, Brunzell JD, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Zinman B, de Boer IH:  Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes. Diabetes Care 36:2423-2429, 2013. PMCID: PMC3714470 Analytic Core

Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer MA, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A:  Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1).  Circ Res 112:1345-1354, 2013. PMCID: PMC3767575 Adipose Tissue Lipid Biology Core

Tsubota Y, Frey JM, Tai PW, Welikson RE, Raines EW: Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases. J Immunol 190:4236-4244, 2013. PMCID: PMC3622190 Biostatistics Subcore

Williams PT, Zhao XQ, Marcovina SM, Brown BG, Krauss RM: Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS). PLos One 8:e56782, 2013. PMCID: PMC358409 Human Studies Core (discontinued Core)

Kremsdorf RA, Hoofnagle AN, Kratz M, Weigle DS, Callahan HS, Purnell JQ, Horgan AM, de Boer IH, Kestenbaum BR:  Effects of a high-protein diet on regulation of phosphorus homeostasis. J Clin Endocrinol Metab 98:1307-1313, 2013. PMCID: PMC3590482 Analytic Core and Human Studies Core (discontinued Core)

Faulenbach MV, Wright LA, Lorenzo C, Utzschneider KM, Goedecke JH, Fujimoto WY, Boyko EJ, McNeely MJ, Leonetti DL, Haffner SM, Kahn SE: American Diabetes Association GENNID Study Group:  Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index. Diabetes Complications. 27:158-161, 2013.  PMCID: PMC3618472 Human Studies Core (discontinued Core)

Nguyen N, Naik V, Speer MY:  Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice. Cardiovasc Pathol 22:167-175, 2013.  PMCID: PMC3481013 Animal Studies Core (discontinued Core)

Bosworth C, Sachs MC, Duprez D, Hoofnagle AN, Ix JH, Jacobs DR Jr, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH:  Parathyroid hormone and arterial dysfunction in the Multi-Ethnic Study of Atherosclerosis. Clin Endocrinol 79:429-436, 2013. PMCID: PMC3664253 Analytic Core

Li Xi, Gonzalez O, Barnhart S, Kramer F, Shen X, Vivekanandan-Giri, A, Kanter JE, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JA,  Bornfeldt KE:  Endothelial Acyl-CoA Synthetase 1 is not required for saturated fatty acid mediated inflammatory and apoptotic effects.  ArteriosclerThromb Vasc Biol 33:232-240, 2013.  PMCID: PMC3553857 Adipose Tissue Lipid Biology Core

van Ballegooijen AJ, Visser M, Kestenbaum B, Siscovick D, de Boer IH, Gottdiener JS, Defilippi CR, Brouwer IA: Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). American J Cardiol 111:418-424, 2013. PMCID: PMC3546140 Analytic Core

Wander PL, Boyko EJ, Leonetti DL, McNeely MJ, Kahn SE, Fujimoto WY:  Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.  Diabetes Care 36:289-93, 2013. PMCID: PMC3554282 Human Studies Core (discontinued Core)

de Boer IH, Sachs M, Hoofnagle AN, Utzschneider KM, Kahn SE, Kestenbaum B, Himmelfarb J:  Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease. Kidney Int 83:323-330, 2013. PMCID: PMC3509239 Analytic Core

Hayashi T, Boyko EJ, Sato KK, McNeely MJ, Leonetti DL, Kahn SE, Fujimoto WY: Patterns of insulin concentration during the OGTT predict the risk of type 2 diabetes in Japanese Americans. 36:1229-1235, 2013. PMCID: PMC3631850 Human Studies Core (discontinued Core)

Tateya S, Rizzo NO, Handa P, Cheng AM, Morgan-Stevenson V, Ogimoto K, Kanter JE, Bornfeldt KA, Daum G, Clowes AW, Chait A, Kim F:  VASP increases hepatic fatty oxidation by activating AMPK in mice. Diabetes 62:1913-1922, 2013. PMCID: PMC3661609 Energy Balance Glucose Metabolism Core, Adipose Tissue Lipid Biology Core

Meek T, Wisse BE, Thaler JP, Guyenet S, Matsen M, Fischer J, Taborsky Jr. G, Schwartz MW, Morton GJ:  BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes 62:1512-1518, 2013. PMCID: PMC3636618 Energy Balance Glucose Metabolism Core, Analytic Core

2012

Lee WJ, Chait A, Kim F: P-selectin glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction. Diabetes 61:3070-3071, 2012. PMCID: PMC3501877 Adipose Tissue Lipid Biology Core

de Boer IH, Sachs MC, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group:  Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab 97:4780-4788, 2012. PMCID: PMC3513544 Analytic Core

Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN:  Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clin Chem 58:1711-1716, 2012.  PMCID:  PMC3731945 Analytic Core

Deo R, Katz R, Shlipak MG, Sotoodehnia N, Psaty BM, Sarnak MJ, Fried LF, Chonchol, M, de Boer IH, Enquobahrie, D, Siscovick D, Kestenbaum B: Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study. Hypertension 58:1021-1028, 2011. PMCID: PMC3337033 Analytic Core

Umemoto T, Subramanian S, Ding Y, Goodspeed L, Wang S, Han CY, Teresa AS, Kim J, O'Brien KD, Chait A:  Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation. J Lipid Res 53:2380-2389, 2012.  PMCID: PMC3466006 Analytic Core, Adipose Tissue Lipid Biology Core, New Investigator Award (Subramanian)

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT:  EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22:304-317, 2012. PMCID: PMC3443395 P&F Award (Wilson)

Gutierrez OM, Katz R, Peralta CA, de Boer IH, Siscovick D, Wolf M, Diez Roux A, Kestenbaum B, Nettleton JA, Ix JH: Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: The Multi-Ethnic Study of Atherosclerosis (MESA). J Ren Nutr 22:480-489, 2012. PMCID: PMC3321388 Analytic Core

Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE:  Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. PLoS One 7:e41473, 2012. PMCID: PMC3425585  Energy Balance Glucose Metabolism Core

Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Circ Cardiovasc Genet. 5:422-429, 2012. PMCID: PMC3422654 Analytic Core

Vaisar T:  Proteomics investigations of HDL: challenges and promise. Curr Vasc Pharmacol 10:410-421, 2012. (Review). PMCID:  PMC3685576 P&F Award (Vaisar)

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J, O'Brien KD, Chait A: Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 32:1596-1604, 2012.  PMCID:  PMC3748807 Adipose Tissue Lipid Biology Core, Energy Balance Glucose Metabolism Core

Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST: Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J Lipid Res 53:1376-1383, 2012. PMCID: PMC3371249 Analytic Core, Energy Balance Glucose Metabolism Core, P&F Award (Vaisar)