Recent Publications

Neurobiology of food intake in health and disease.

Morton GJ, Meek TH, Schwartz MW. Neurobiology of food intake in health and diseaseNat Rev Neurosci. Jun;15(6):367-78, 2014. Review. PMCID: PMC4076116

Published June 2014

Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis.

Nishizawa T, Kanter JE, Kramer F, Barnhart S, Shen X, Vivekanandan-Giri A, Wall VZ, Kowitz J, Devaraj S, O'Brien KD, Pennathur S, Tang J, Miyaoka RS, Raines EW, Bornfeldt KE. Testing the role of myeloid cell glucose flux in inflammation and atherosclerosisCell Rep. Apr 24;7(2):356-65, 2014. PMCID: PMC4021396

Published April 2014

Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease.

Williams PT, Zhao XQ, Marcovina SM, Otvos JD, Brown BG, Krauss RM. Atherosclerosis. Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease. Apr;233(2):713-20, 2014

Published April 2014

Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women.

Utzschneider KM, Largajolli A, Bertoldo A, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Kahn SE. J Diabetes Complications. Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women. Mar-Apr;28(2):177-84,2014.

Published March 2014

Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans.

Morton GJ, Kaiyala KJ, Foster-Schubert KE, Cummings DE, Schwartz MW.  Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humansJ Clin Endocrinol Metab. 2014 Feb;99(2):E241-5, 2014. PMCID: PMC3913810

Published February 2014

Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA study.

Bansal N, Katz R, de Boer IH, Kestenbaum B, Siscovick DS, Hoofnagle AN, Tracy R, Laughlin GA, Criqui MH, Budoff MJ, Li D, Ix JH. Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA studyJ Clin Endocrinol Metab. 2013 Dec;98(12):4890-8. doi: 10.1210/jc.2013-2286, 2013. PMCID: PMC3849680

Published December 2013

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species.

den Hartigh LJ1, Han CYWang SOmer MChait A. 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species 2013 Nov;54(11):2964-78, 2013. PMCID: PMC3793601 

Published November 2013

Cooperation between brain and islet in glucose homeostasis and diabetes.

Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D'Alessio D. Cooperation between brain and islet in glucose homeostasis and diabetesNature. 2013 Nov 7;503(7474):59-66. Review, 2013. PMCID: PMC3983910

Published November 2013

FGF19 action in the brain induces insulin-independent glucose lowering.

Morton GJ, Matsen ME, Bracy DP, Meek TH, Nguyen HT, Stefanovski D, Bergman RN, Wasserman DH, Schwartz MW. FGF19 action in the brain induces insulin-independent glucose lowering.  2013 Nov 1;123(11):4799-808, 2013. PMCID: PMC3809800 

Published November 2013

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice.

Subramanian S1, Turner MSDing YGoodspeed LWang SBuckner JHO'Brien KGetz GSReardon CAChait A. Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice 2013 Oct;54(10):2831-41, 2013. PMCID: PMC3770095

Published October 2013

Parathyroid hormone and arterial dysfunction in the Multi-Ethnic Study of Atherosclerosis.

Bosworth C, Sachs MC, Duprez D, Hoofnagle AN, Ix JH, Jacobs DR Jr, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH:  Parathyroid hormone and arterial dysfunction in the Multi-Ethnic Study of Atherosclerosis. Clin Endocrinol 79:429-436, 2013. PMCID: PMC3664253

Published September 2013

Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes.

Sachs MC, Brunzell JD, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Zinman B, de Boer IH:  Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes. Diabetes Care 36:2423-2429, 2013. PMCID: PMC3714470 

Published August 2013

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium.

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, Gudnason V, Harris TB, Kathiresan S, Kraaij R, Launer LJ, Levy D, Liu Y, Mosley T, Peloso GM, Psaty BM, Rich SS, Rivadeneira F, Siscovick DS, Smith AV, Uitterlinden A, van Duijn CM, Wilson JG, O'Donnell CJ, Rotter JI, Boerwinkle E: Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. Plos One 8:e68095, 2013. PMCID: PMC3709915

Published July 2013

T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, Den Hartigh LJ, Averill MM, O'Brien KD, Ledbetter J, Chait A: T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice. Plos One 8:e67709, 2013. PMCID: PMC3699637

Published July 2013

Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis.

Smits MM, Woudstra P, Utzschneider KM, Tong J, Gerchman F, Faulenbach M, Carr DB, Aston-Mourney K, Chait A, Knopp RH, Meigs JB, Boyko EJ, Kahn SE: Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis. Ann Epidemiol 23:415-421, 2013.  PMCID: PMC3778191

Published July 2013

Leptin and the brain: then and now

Schwartz MW, Baskin DG: Leptin and the brain: then and now. J Clin Invest 123:2344-2345, 2013. PMCID: PMC3668840

Published June 2013

Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers.

Toriola AT, Cheng TY, Neuhouser ML, Wener MH, Zheng Y, Brown E, Miller JW, Song X, Beresford SA, Gunter MJ, Caudill MA, Ulrich CM: Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. Int J Cancer 132:2648-58, 2013. PMCID: PMC3609926

Published June 2013

Longer T2 relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity.

Lee D, Thaler JP, Berkseth K, Melhorn SJ, Schwartz MW, Schur EA:  Longer T2 relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. Am J Physiol Endocrinol Metab 304:E1245-1250, 2013. PMCID: PMC3680680

Published June 2013

VASP increases hepatic fatty oxidation by activating AMPK in mice.

Tateya S, Rizzo NO, Handa P, Cheng AM, Morgan-Stevenson V, Ogimoto K, Kanter JE,Bornfeldt KA, Daum G, Clowes AW, Chait A, Kim F:  VASP increases hepatic fatty oxidation by activating AMPK in mice. Diabetes 62:1913-1922, 2013. PMCID: PMC3661609 

Published June 2013

High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes.

Guyenet SI, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP:  High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Res 1512:97-105, 2013.  PMCID:  PMC3684737

Published May 2013

A role for natriuretic peptides in the central control of energy balance?

Berkseth K, Schur E, Schwartz MW:  A role for natriuretic peptides in the central control of energy balance? Diabetes 62:1379-1381, 2013. (Review). PMCID: PMC3636633

Published May 2013

Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1).

Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer MA, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A:  Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1).  Circ Res 112:1345-1354, 2013. PMCID: PMC3767575 

Published May 2013

BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production.

Meek T, Wisse BE, Thaler JP, Guyenet S, Matsen M, Fischer J, Taborsky Jr. G, Schwartz MW, Morton GJ:  BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes 62:1512-1518, 2013. PMCID: PMC3636618

Published May 2013

Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.

Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM: Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem. 288:10722-10735, 2013. PMCID: PMC3624452

Published April 2013

In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.

Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek THOgimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Am J Physiol Endo Metab 304:E734-746, 2013. PMCID: PMC3625754 

Published April 2013

Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases.

Tsubota Y, Frey JM, Tai PW, Welikson RE, Raines EW: Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases. J Immunol 190:4236-4244, 2013. PMCID: PMC3622190 

Published April 2013

Effects of a high-protein diet on regulation of phosphorus homeostasis.

Kremsdorf RA, Hoofnagle AN, Kratz M, Weigle DS, Callahan HS, Purnell JQ, Horgan AM, de Boer IH, Kestenbaum BR:  Effects of a high-protein diet on regulation of phosphorus homeostasis. J Clin Endocrinol Metab 98:1307-1313, 2013. PMCID: PMC3590482

Published March 2013

American Diabetes Association GENNID Study Group: Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index.

Faulenbach MV, Wright LA, Lorenzo C, Utzschneider KM, Goedecke JH, Fujimoto WY, Boyko EJ, McNeely MJ, Leonetti DL, Haffner SM, Kahn SE: American Diabetes Association GENNID Study Group:  Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index. Diabetes Complications. 27:158-161, 2013.  PMCID: PMC3618472 

Published March 2013

Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice.

Nguyen N, Naik V, Speer MY:  Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice. Cardiovasc Pathol 22:167-175, 2013.  PMCID: PMC3481013 

Published March 2013

Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food.

Guyenet SJ, Matsen ME, Morton GJ, Kaiyala KJ, Schwartz MW. Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic foodMol Metab. 2013 Feb 11;2(2):116-22, 2013. PMCID: PMC3817387 

Published February 2013

Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS).

Williams PT, Zhao XQ, Marcovina SM, Brown BG, Krauss RM: Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS). PLos One 8:e56782, 2013. PMCID: PMC3584097

Published February 2013

Endothelial Acyl-CoA Synthetase 1 is not required for saturated fatty acid mediated inflammatory and apoptotic effects.

Li Xi, Gonzalez O, Barnhart S, Kramer F, Shen X, Vivekanandan-Giri, A, Kanter JE, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JA,  Bornfeldt KE:  Endothelial Acyl-CoA Synthetase 1 is not required for saturated fatty acid mediated inflammatory and apoptotic effects.  ArteriosclerThromb Vasc Biol 33:232-240, 2013.  PMCID: PMC3553857 

Published February 2013

Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study).

van Ballegooijen AJ, Visser M, Kestenbaum B, Siscovick D, de Boer IH, Gottdiener JS, Defilippi CR, Brouwer IA: Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). American J Cardiol 111:418-424, 2013. PMCID: PMC3546140 

Published February 2013

Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.

Wander PL, Boyko EJ, Leonetti DL, McNeely MJ, Kahn SE, Fujimoto WY:  Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.  Diabetes Care 36:289-93, 2013. PMCID: PMC3554282 

Published February 2013

Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease.

de Boer IH, Sachs M, Hoofnagle AN, Utzschneider KM, Kahn SE, Kestenbaum B, Himmelfarb J:  Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease. Kidney Int 83:323-330, 2013. PMCID: PMC3509239

Published February 2013

P-selection glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction.

Lee WJ, Chait A, Kim F: P-selectin glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction. Diabetes 61:3070-3071, 2012. PMCID: PMC3501877 

Published December 2012

Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group: Circulating vitamin D metabolites and kidney disease in type 1 diabetes.

de Boer IH, Sachs MC, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group:  Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab 97:4780-4788, 2012. PMCID: PMC3513544

Published December 2012

Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.

Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN:  Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clin Chem 58:1711-1716, 2012.  PMCID:  PMC3731945 

Published December 2012

Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation.

Umemoto T, Subramanian S, Ding Y, Goodspeed L, Wang S, Han CY, Teresa AS, Kim J,O'Brien KD, Chait A:  Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation. J Lipid Res 53:2380-2389, 2012.  PMCID: PMC3466006 

Published November 2012

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT:  EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22:304-317, 2012. PMCID: PMC3443395 

Published September 2012

Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: The Multi-Ethnic Study of Atherosclerosis (MESA).

Gutierrez OM, Katz R, Peralta CA, de Boer IH, Siscovick D, Wolf M, Diez Roux A,Kestenbaum B, Nettleton JA, Ix JH: Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: The Multi-Ethnic Study of Atherosclerosis (MESA). J Ren Nutr 22:480-489, 2012. PMCID: PMC3321388 

Published September 2012

Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice.

Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE:  Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. PLoS One 7:e41473, 2012. PMCID: PMC3425585 

Published August 2012

Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.

Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Circ Cardiovasc Genet. 5:422-429, 2012. PMCID: PMC3422654 

Published August 2012

Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity.

Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST: Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J Lipid Res 53:1376-1383, 2012. PMCID: PMC3371249 

Published July 2012

Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J,O'Brien KD, Chait A: Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 32:1596-1604, 2012.  PMCID:  PMC3748807 

Published July 2012

Proteomics investigations of HDL: challenges and promise.

Vaisar T:  Proteomics investigations of HDL: challenges and promise. Curr Vasc Pharmacol 10:410-421, 2012. (Review). PMCID:  PMC3685576 

Published July 2012

Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study.

Deo R, Katz R, Shlipak MG, Sotoodehnia N, Psaty BM, Sarnak MJ, Fried LF, Chonchol, M, de Boer IH, Enquobahrie, D, Siscovick D, Kestenbaum B: Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study. Hypertension 58:1021-1028, 2011. PMCID: PMC3337033 

Published December 2011