Recent Publications

In adult twins, visceral fat accumulation depends more on exceeding sex-specific adiposity thresholds than on genetics.

Bosch TA, Chow L, Dengel DR, Melhorn SJ, Webb M, Yancey D, Callahan H, De Leon MR, Tyagi V, Schur EA. In adult twins, visceral fat accumulation depends more on exceeding sex-specific adiposity thresholds than on genetics. Metabolism S0026-0495:00163-8, 2.15. PMCID: PMC

Published June 2015

Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis.

Marsillach J, Becker JO, Vaisar T, Hahn BH, Brunzell JD, Furlong CE, de Boer IH, McMahon MA, Hoofnagle AN. Paraoxonase-3 is depleted from the high-density lipoproteins of autoimmune disease patients with subclinical atherosclerosis. J Proteome Res 14:2046-54, 2015. PMCID: PMC4434596

Published May 2015

Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study.

Moore A, Hochner H, Sitlani CM, Williams MA, Hoofnagle AN, de Boer IH, Kestenbaum B, Siscovick DS, Friedlander Y, Enquobahrie DA. Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study. Public Health Nutr 18:1324-31, 2015. PMCID: PMC

Published May 2015

Effects of murine norovirus on atherosclerosis in ldlr(-/-) mice depends on the timing of infection.

Paik J, Kwok F, Seamons A, Brabb T, Kim J, Sullivan B, Hsu C, O'Brien KD, Maggio-Price L. Effects of murine norovirus on atherosclerosis in ldlr(-/-) mice depends on the timing of infection. Comp Med 65:114-22, 2015. PMCID: PMC4408896

Published April 2015

Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions.

Kaiyala KJ, Ogimoto K, Nelson JT, Schwartz MW, Morton GJ. Leptin signaling is required for adaptive changes in food intake, but not energy expenditure, in response to different thermal conditions. PLos One 10:e0119391, 2015. PMCID: PMC4355297 

Published March 2015

Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys.

Blevins JE, Graham JL, Morton GJ, Bales KL, Schwartz MW, Baskin DG, Havel PJ. Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys. Am J Physiol Regul Integr Comp Physiol 308:R431-8, 2015. 

Published March 2015

Mineral metabolism and the right ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA).

Mathew JS, Leary PJ, Bansal N, Deo R, Lima JA, Siscovick DS, Kestenbaum B, Kawut SM, de Boer IH. Mineral metabolism and the right ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 65:521-3, 2015. PMCID: PMC4377296

Published March 2015

Can the history of modern endocrinology shape the future of obesity?

Schwartz MW. Can the history of modern endocrinology shape the future of obesity? Mol Endocrinol 29:155-7, 2015. PMCID: PMC4318879

Published February 2015

Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis.

Brown J, de Boer IH, Robinson-Cohen C, Siscovick DS, Kestenbaum B, Allison M, Vaidya A. Aldosterone, parathyroid hormone, and the use of renin-angiotensin-aldosterone system inhibitors: the multi-ethnic study of atherosclerosis. J Clin Endocrinol Metab 100:490-9, 2015. PMCID: PMC4318894

Published February 2015

Gut-brain mechanisms controlling glucose homeostasis.

Scarlett JM, Schwartz MW. Gut-brain mechanisms controlling glucose homeostasis. F1000Prime Rep 7:12, 2015. PMCID: PMC4311273

Published January 2015

Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy.

Reyes NL, Banks GB, Tsang M, Margineantu D, Gu H, Djukovic D, Chan J, Torres M, Liggitt HD, Hirenallur-S DK, Hockenbery DM, Raftery D, Iritani BM. Fnip1 regulates skeletal muscle fiber type specification, fatigue resistance, and susceptibility to muscular dystrophy. Proc Natl Acad Sci U S A 112:424-9, 2015. PMCID: PMC4299192

Published January 2015

Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice.

Spiezio SH, Amon LM, McMillen TS, Vick CM, Houston BA, Caldwell M, Ogimoto K, Morton GJ, Kirk EA, Schwartz MW, Nadeau JH, LeBoeuf RC. Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mammalian Genome 25:549-63, 2014. PMCID: PMC4241139

Published December 2014

Serum parathyroid hormone and 25-hydroxyvitamin D concentrations and risk of incident heart failure: the multi-ethnic study of atherosclerosis.

Bansal N, Zelnick L, Robinson-Cohen C, Hoofnagle AN, Ix JH, Lima JA, Shoben AB, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH. Serum parathyroid hormone and 25-hydroxyvitamin D concentrations and risk of incident heart failure: the multi-ethnic study of atherosclerosis. J Am Heart Assoc 3:e001278, 2014. PMCID: PMC4338718

Published December 2014

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans.

Melhorn SJ, Tyagi V, Smeraglio A, Roth CL, Schur EA. Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite 82:85-90, 2014. PMCID: PMC4171349

Published November 2014

Exercise, energy intake, glucose homeostasis, and the brain.

van Praag H, Fleshner M, Schwartz MW, Mattson MP. Exercise, energy intake, glucose homeostasis, and the brain. J Neurosci 34:15139-49, 2014. PMCID: PMC4228123

Published November 2014

Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes.

Meek TH, Matsen ME, Damian V, Cubelo A, Chua SC Jr, Morton GJ. Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes. Endocinology 155:4157-67, 2014. PMCID: PMC4197991

Published November 2014

Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans.

Melhorn SJ, Tyagi V, Smeraglio A, Roth CL, Schur EA. Initial evidence that GLP-1 receptor blockade fails to suppress postprandial satiety or promote food intake in humans. Appetite 82:85-90, 2014. PMCID: PMC4171349

Published November 2014

Association of fibroblast growth factor-23 with arterial stiffness in the Multi-Ethnic Study of Atherosclerosis.

Hsu JJ, Katz R, Ix JH, de Boer IH, Kestenbaum B, Shlipak MG. Association of fibroblast growth factor-23 with arterial stiffness in the Multi-Ethnic Study of Atherosclerosis. Nephril Dial Transplant 29:2099-105, 2014. PMCID: PMC4209876

Published November 2014

The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice.

Averill MM, Kim EJ, Goodspeed L, Wang S, Subramanian S, Den Hartigh LJ, Tang C, Ding Y, Reardon CA, Getz GS, Chait A. The apolipoprotein-AI mimetic peptide L4F at a modest dose does not attenuate weight gain, inflammation, or atherosclerosis in LDLR-null mice. PLoS One 9:e109252, 2014. PMCID: PMC4186861

Published October 2014

Effects of dietary fat and saturated fat content on liver fat and markers of oxidative stress in overweight/obese men and women under weight-stable conditions.

Marina A, von Frankenberg AD, Suvag S, Callahan HS, Kratz M, Richards TL, Utzschneider KM. Effects of dietary fat and saturated fat content on liver fat and markers of oxidative stress in overweight/obese men and women under weight-stable conditions. Nutrients 6:4678-90, 2014. PMCID: PMC4245556

Published October 2014

Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance.

Cheng AM, Rizzo-DeLeon N, Wilson CL, Lee WJ, Tateya S, Clowes AW, Schwartz MW, Kim F. Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance. Am J Physiol Endocrinol Metab 307:E571-9, 2014. PMCID: PMC4187027

Published October 2014

Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest.

Lemaitre RN, King IB, Rice K, McKnight B, Sotoodehnia N, Rea TD, Johnson CO, Raghunathan TE, Cobb LA, Mozaffarian D, Siscovick DS. Erythrocyte very long-chain saturated fatty acids associated with lower risk of incident sudden cardiac arrest. Prostaglandins Leukot Essent Fatty Acids 91:149-53, 2014. PMCID: PMC4156887

Published October 2014

Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA).

Driver TH, Shlipak MG, Katz R, Goldenstein L, Sarnak MJ, Hoofnagle AN, Siscovick DS, Kestenbaum B, de Boer IH, Ix JH. Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis 64:534-41, 2014. PMCID: PMC4177290

Published October 2014

Control of hepatic glucose metabolism by islet and brain.

Rojas JM, Schwartz MW. Control of hepatic glucose metabolism by islet and brain. Diabetes Obes Metab 1:33-40, 2014. PMCID: PMC4191916

Published September 2014

Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice.

den Hartigh LJ, Wang S, Goodspeed L, Ding Y, Averill M, Subramanian S, Wietecha T, O'Brien KD, Chait A. Deletion of serum amyloid A3 improves high fat high sucrose diet-induced adipose tissue inflammation and hyperlipidemia in female mice. PLoS One, 2014. PMCID: PMC4177399

Published September 2014

Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology 155:3409-20, 2014. PMCID: PMC4138576

Published September 2014

FGF21 is an endocrine signal of protein restriction.

Laeger T, Henagan TM, Albarado DC, Redman LM, Bray GA, Noland RC, Münzberg H, Hutson SM, Gettys TW, Schwartz MW, Morrison CD. FGF21 is an endocrine signal of protein restriction. J Clin Invest 124:3913-22, 2014. PMCID: PMC4153701

Published September 2014

Vitamin D and the risk of dementia and Alzheimer disease.

Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, Lopez OL, Kos K, Soni M, Llewellyn DJ. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 83:920-8, 2014. PMCID: PMC4153851

Published September 2014

Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study.

Berkseth KE, Guyenet SJ, Melhorn SJ, Lee D, Thaler JP, Schur EA, Schwartz MW. Hypothalamic gliosis associated with high-fat diet feeding is reversible in mice: a combined immunohistochemical and magnetic resonance imaging study. Endocrinology 155:2858-67, 2014. PMCID: PMC4098007

Published August 2014

Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats.

Ho JM, Anekonda VT, Thompson BW, Zhu M, Curry RW, Hwang BH, Morton GJ, Schwartz MW, Baskin DG, Appleyard SM, Blevins JE. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology 155:2845-57, 2014. PMCID: PMC4098005

Published August 2014

Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials.

de Boer IH, Sachs MC, Chonchol M, Himmelfarb J, Hoofnagle AN, Ix JH, Kremsdorf RA, Lin YS, Mehrotra R, Robinson-Cohen C, Siscovick DS, Steffes MW, Thummel KE, Tracy RP, Wang Z, Kestenbaum B. Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials. Am J Kidney Dis 64:187-97, 2014. PMCID: PMC4111986

Published August 2014

Mathematical model for the contribution of individual organs to non-zero y-intercepts in single and multi-compartment linear models of whole-body energy expenditure.

Kaiyala KJ. Mathematical model for the contribution of individual organs to non-zero y-intercepts in single and multi-compartment linear models of whole-body energy expenditure. PLoS One 28:9, 2014. PMCID: PMC4113365

Published July 2014

Fibroblast growth factor-23 and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS).

Mathew JS, Sachs MC, Katz R, Patton KK, Heckbert SR, Hoofnagle AN, Alonso A, Chonchol M, Deo R, Ix JH, Siscovick DS, Kestenbaum B, de Boer IH. Fibroblast growth factor-23 and incident atrial fibrillation: the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS). Circulation 130:298-307, 2014. PMCID: PMC4108550

Published July 2014

From lost in translation to paradise found: enabling protein biomarker method transfer by mass spectrometry.

Grant RP, Hoofnagle AN. From lost in translation to paradise found: enabling protein biomarker method transfer by mass spectrometry. Clin Chem 60:941-4, 2014. PMCID: PMC4315805

Published July 2014

Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans.

Kratz M, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Callahan HS, Song X, Di C, Utzschneider KM. Dairy fat intake is associated with glucose tolerance, hepatic and systemic insulin sensitivity, and liver fat but not β-cell function in humans. Am J Clin Nutr 99:1385-96, 2014. PMCID: PMC4021783

Published July 2014

Neurobiology of food intake in health and disease.

Morton GJ, Meek TH, Schwartz MW. Neurobiology of food intake in health and diseaseNat Rev Neurosci 15:367-78, 2014. Review. PMCID: PMC4076116

Published June 2014

Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.

Dai DF, Karunadharma PP, Chiao YA, Basisty N, Crispin D, Hsieh EJ, Chen T, Gu H, Djukovic D, Raftery D, Beyer RP, MacCoss MJ, Rabinovitch PS. Altered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart. Aging Cell 13:529-39, 2014. PMCID: PMC4040127

Published June 2014

Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development.

Park H, Tsang M, Iritani BM, Bevan MJ. Metabolic regulator Fnip1 is crucial for iNKT lymphocyte development. Proc Natl Acad Sci U S A 111:7066-71, 2014. PMCID: PMC4024901

Published May 2014

Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis.

Kestenbaum B, Sachs MC, Hoofnagle AN, Siscovick DS, Ix JH, Robinson-Cohen C, Lima JA, Polak JF, Blondon M, Ruzinski J, Rock D, de Boer IH. Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis. Circ Heart Fail 7:409-17, 2014. PMCID: PMC4031265

Published May 2014

Testing the role of myeloid cell glucose flux in inflammation and atherosclerosis.

Nishizawa T, Kanter JE, Kramer F, Barnhart S, Shen X, Vivekanandan-Giri A, Wall VZ, Kowitz J, Devaraj S, O'Brien KD, Pennathur S, Tang J, Miyaoka RS, Raines EW, Bornfeldt KE. Testing the role of myeloid cell glucose flux in inflammation and atherosclerosisCell Rep 7:356-65, 2014. PMCID: PMC4021396

Published April 2014

Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease.

Williams PT, Zhao XQ, Marcovina SM, Otvos JD, Brown BG, Krauss RM. Atherosclerosis. Comparison of four methods of analysis of lipoprotein particle subfractions for their association with angiographic progression of coronary artery disease. Atherosclerosis 233:713-20, 2014. PMCID: PMC3990359

Published April 2014

Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA).

Linefsky JP, O'Brien KD, Sachs M, Katz R, Eng J, Michos ED, Budoff MJ, de Boer I, Kestenbaum B. Serum phosphate is associated with aortic valve calcification in the Multi-ethnic Study of Atherosclerosis (MESA). Atherosclerosis 233:331-7, 2014. PMCID: PMC3992246

Published April 2014

Association of 25-hydroxyvitamin D and parathyroid hormone with incident hypertension: MESA (Multi-Ethnic Study of Atherosclerosis).

van Ballegooijen AJ, Kestenbaum B, Sachs MC, de Boer IH, Siscovick DS, Hoofnagle AN, Ix JH, Visser M, Brouwer IA. Association of 25-hydroxyvitamin D and parathyroid hormone with incident hypertension: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 63:1214-22, 2014. PMCID: PMC3999436

Published April 2014

Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women.

Utzschneider KM, Largajolli A, Bertoldo A, Marcovina S, Nelson JE, Yeh MM, Kowdley KV, Kahn SE. J Diabetes Complications. Serum ferritin is associated with non-alcoholic fatty liver disease and decreased Β-cell function in non-diabetic men and women. Journal of Diabetes and its Complications 28:177-84, 2014. PMCID: PMC3943487

Published March 2014

Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humans.

Morton GJ, Kaiyala KJ, Foster-Schubert KE, Cummings DE, Schwartz MW.  Carbohydrate feeding dissociates the postprandial FGF19 response from circulating bile acid levels in humansJ Clin Endocrinol Metab 99:E241-5, 2014. PMCID: PMC3913810

Published February 2014

Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice.

Wei H, Averill MM, McMillen TS, Dastvan F, Mitra P, Subramanian S, Tang C, Chait A, Leboeuf RC. Modulation of adipose tissue lipolysis and body weight by high-density lipoproteins in mice. Nutr Diabetes 4:e108, 2014. PMCID: PMC3940828

Published February 2014

Hormones and diet, but not body weight, control hypothalamic microglial activity.

Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia 62:17-25, 2014. PMCID: PMC4213950

Published January 2014

Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA study.

Bansal N, Katz R, de Boer IH, Kestenbaum B, Siscovick DS, Hoofnagle AN, Tracy R, Laughlin GA, Criqui MH, Budoff MJ, Li D, Ix JH. Influence of estrogen therapy on calcium, phosphorus, and other regulatory hormones in postmenopausal women: the MESA studyJ Clin Endocrinol Metab 98:4890-8, 2013. PMCID: PMC3849680

Published December 2013

10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen species.

den Hartigh LJ1, Han CYWang SOmer MChait A. 10E,12Z-conjugated linoleic acid impairs adipocyte triglyceride storage by enhancing fatty acid oxidation, lipolysis, and mitochondrial reactive oxygen speciesJ Lipid Res 54:2964-78, 2013. PMCID: PMC3793601 

Published November 2013

Cooperation between brain and islet in glucose homeostasis and diabetes.

Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D'Alessio D. Cooperation between brain and islet in glucose homeostasis and diabetesNature 503:59-66. Review, 2013. PMCID: PMC3983910

Published November 2013

FGF19 action in the brain induces insulin-independent glucose lowering.

Morton GJ, Matsen ME, Bracy DP, Meek TH, Nguyen HT, Stefanovski D, Bergman RN, Wasserman DH, Schwartz MW. FGF19 action in the brain induces insulin-independent glucose lowering.  123:4799-808, 2013. PMCID: PMC3809800 

Published November 2013

25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis.

Blondon M, Sachs M, Hoofnagle AN, Ix JH, Michos ED, Korcarz C, Gepner AD, Siscovick DS, Kaufman JD, Stein JH, Kestenbaum B, de Boer IH. 25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the multi-ethnic study of atherosclerosis. Arterioscler Thromb Vasc Biol 33:2639-45, 2013. PMCID: PMC3956469

Published November 2013

Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice.

Subramanian S1, Turner MSDing YGoodspeed LWang SBuckner JHO'Brien KGetz GSReardon CAChait A. Increased levels of invariant natural killer T lymphocytes worsen metabolic abnormalities and atherosclerosis in obese mice 54:2831-41, 2013. PMCID: PMC3770095

Published October 2013

Parathyroid hormone and arterial dysfunction in the Multi-Ethnic Study of Atherosclerosis.

Bosworth C, Sachs MC, Duprez D, Hoofnagle AN, Ix JH, Jacobs DR Jr, Peralta CA, Siscovick DS, Kestenbaum B, de Boer IH:  Parathyroid hormone and arterial dysfunction in the Multi-Ethnic Study of Atherosclerosis. Clin Endocrinol 79:429-436, 2013. PMCID: PMC3664253

Published September 2013

Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia.

Meek TH, Matsen ME, Dorfman MD, Guyenet SJ, Damian V, Nguyen HT, Taborsky GJ Jr, Morton GJ. Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia. Endocrinology 154:3067-76, 2013. PMCID: PMC3749482

Published September 2013

Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes.

Sachs MC, Brunzell JD, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Zinman B, de Boer IH:  Circulating vitamin D metabolites and subclinical atherosclerosis in type 1 diabetes. Diabetes Care 36:2423-2429, 2013. PMCID: PMC3714470 

Published August 2013

Hypothalamic inflammation: marker or mechanism of obesity pathogenesis?

Thaler JP, Guyenet SJ, Dorfman MD, Wisse BE, Schwartz MW. Hypothalamic inflammation: marker or mechanism of obesity pathogenesis? Diabetes 62:2629-34, 2013. PMCID: PMC3717869

Published August 2013

Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium.

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, Gudnason V, Harris TB, Kathiresan S, Kraaij R, Launer LJ, Levy D, Liu Y, Mosley T, Peloso GM, Psaty BM, Rich SS, Rivadeneira F, Siscovick DS, Smith AV, Uitterlinden A, van Duijn CM, Wilson JG, O'Donnell CJ, Rotter JI, Boerwinkle E: Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One 8:e68095, 2013. PMCID: PMC3709915

Published July 2013

T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice

Montes VN, Turner MS, Subramanian S, Ding Y, Hayden-Ledbetter M, Slater S, Goodspeed L, Wang S, Omer M, Den Hartigh LJ, Averill MM, O'Brien KD, Ledbetter J, Chait A: T cell activation inhibitors reduce CD8+ T cell and pro-inflammatory macrophage accumulation in adipose tissue of obese mice. Plos One 8:e67709, 2013. PMCID: PMC3699637

Published July 2013

Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis.

Smits MM, Woudstra P, Utzschneider KM, Tong J, Gerchman F, Faulenbach M, Carr DB, Aston-Mourney K, Chait A, Knopp RH, Meigs JB, Boyko EJ, Kahn SE: Adipocytokines as features of the metabolic syndrome determined using confirmatory factor analysis. Ann Epidemiol 23:415-421, 2013.  PMCID: PMC3778191

Published July 2013

Leptin and the brain: then and now

Schwartz MW, Baskin DG: Leptin and the brain: then and now. J Clin Invest 123:2344-2345, 2013. PMCID: PMC3668840

Published June 2013

Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers.

Toriola AT, Cheng TY, Neuhouser ML, Wener MH, Zheng Y, Brown E, Miller JW, Song X, Beresford SA, Gunter MJ, Caudill MA, Ulrich CM: Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. Int J Cancer 132:2648-58, 2013. PMCID: PMC3609926

Published June 2013

Longer T2 relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity.

Lee D, Thaler JP, Berkseth K, Melhorn SJ, Schwartz MW, Schur EA:  Longer T2 relaxation time is a marker of hypothalamic gliosis in mice with diet-induced obesity. Am J Physiol Endocrinol Metab 304:E1245-1250, 2013. PMCID: PMC3680680

Published June 2013

VASP increases hepatic fatty oxidation by activating AMPK in mice.

Tateya S, Rizzo NO, Handa P, Cheng AM, Morgan-Stevenson V, Ogimoto K, Kanter JE,Bornfeldt KA, Daum G, Clowes AW, Chait A, Kim F:  VASP increases hepatic fatty oxidation by activating AMPK in mice. Diabetes 62:1913-1922, 2013. PMCID: PMC3661609 

Published June 2013

High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes.

Guyenet SI, Nguyen HT, Hwang BH, Schwartz MW, Baskin DG, Thaler JP:  High-fat diet feeding causes rapid, non-apoptotic cleavage of caspase-3 in astrocytes. Brain Res 1512:97-105, 2013.  PMCID:  PMC3684737

Published May 2013

A role for natriuretic peptides in the central control of energy balance?

Berkseth K, Schur E, Schwartz MW:  A role for natriuretic peptides in the central control of energy balance? Diabetes 62:1379-1381, 2013. (Review). PMCID: PMC3636633

Published May 2013

Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1).

Umemoto T, Han CY, Mitra P, Averill MM, Tang C, Goodspeed L, Omer MA, Wang S, Den Hartigh LJ, Wei H, Kim EJ, Kim J, O'Brien KD, Chait A:  Apolipoprotein A-I and HDL have anti-inflammatory effects on adipocytes via cholesterol transporters; ATP-binding cassette (ABC) A-1, ABCG-1 and scavenger receptor B-1(SRB-1).  Circ Res 112:1345-1354, 2013. PMCID: PMC3767575 

Published May 2013

BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production.

Meek T, Wisse BE, Thaler JP, Guyenet S, Matsen M, Fischer J, Taborsky Jr. G, Schwartz MW, Morton GJ:  BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production. Diabetes 62:1512-1518, 2013. PMCID: PMC3636618

Published May 2013

Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues.

Lu M, Sarruf DA, Li P, Osborn O, Sanchez-Alavez M, Talukdar S, Chen A, Bandyopadhyay G, Xu J, Morinaga H, Dines K, Watkins S, Kaiyala K, Schwartz MW, Olefsky JM: Neuronal Sirt1 deficiency increases insulin sensitivity in both brain and peripheral tissues. J Biol Chem 288:10722-10735, 2013. PMCID: PMC3624452

Published April 2013

In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue.

Matsen ME, Thaler JP, Wisse BE, Guyenet SJ, Meek THOgimoto K, Cubelo A, Fischer JD, Kaiyala KJ, Schwartz MW, Morton GJ In uncontrolled diabetes, thyroid hormone and sympathetic activators induce thermogenesis without increasing glucose uptake in brown adipose tissue. Am J Physiol Endo Metab 304:E734-746, 2013. PMCID: PMC3625754 

Published April 2013

Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases.

Tsubota Y, Frey JM, Tai PW, Welikson RE, Raines EW: Monocyte ADAM17 promotes diapedesis during transendothelial migration: identification of steps and substrates targeted by metalloproteinases. J Immunol 190:4236-4244, 2013. PMCID: PMC3622190 

Published April 2013

Effects of a high-protein diet on regulation of phosphorus homeostasis.

Kremsdorf RA, Hoofnagle AN, Kratz M, Weigle DS, Callahan HS, Purnell JQ, Horgan AM, de Boer IH, Kestenbaum BR:  Effects of a high-protein diet on regulation of phosphorus homeostasis. J Clin Endocrinol Metab 98:1307-1313, 2013. PMCID: PMC3590482

Published March 2013

American Diabetes Association GENNID Study Group: Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index.

Faulenbach MV, Wright LA, Lorenzo C, Utzschneider KM, Goedecke JH, Fujimoto WY, Boyko EJ, McNeely MJ, Leonetti DL, Haffner SM, Kahn SE: American Diabetes Association GENNID Study Group:  Impact of differences in glucose tolerance on the prevalence of a negative insulinogenic index. Diabetes Complications. 27:158-161, 2013.  PMCID: PMC3618472 

Published March 2013

Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice.

Nguyen N, Naik V, Speer MY:  Diabetes mellitus accelerates cartilaginous metaplasia and calcification in atherosclerotic vessels of LDLr mutant mice. Cardiovasc Pathol 22:167-175, 2013.  PMCID: PMC3481013 

Published March 2013

Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic food.

Guyenet SJ, Matsen ME, Morton GJ, Kaiyala KJ, Schwartz MW. Rapid glutamate release in the mediobasal hypothalamus accompanies feeding and is exaggerated by an obesogenic foodMol Metab 2:116-22, 2013. PMCID: PMC3817387 

Published February 2013

Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS).

Williams PT, Zhao XQ, Marcovina SM, Brown BG, Krauss RM: Levels of cholesterol in small LDL particles predict atherosclerosis progression and incident CHD in the HDL-Atherosclerosis Treatment Study (HATS). PLos One 8:e56782, 2013. PMCID: PMC3584097

Published February 2013

Endothelial Acyl-CoA Synthetase 1 is not required for saturated fatty acid mediated inflammatory and apoptotic effects.

Li Xi, Gonzalez O, Barnhart S, Kramer F, Shen X, Vivekanandan-Giri, A, Kanter JE, Handa P, Pennathur S, Kim F, Coleman RA, Schaffer JA,  Bornfeldt KE:  Endothelial Acyl-CoA Synthetase 1 is not required for saturated fatty acid mediated inflammatory and apoptotic effects.  ArteriosclerThromb Vasc Biol 33:232-240, 2013.  PMCID: PMC3553857 

Published February 2013

Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study).

van Ballegooijen AJ, Visser M, Kestenbaum B, Siscovick D, de Boer IH, Gottdiener JS, Defilippi CR, Brouwer IA: Relation of vitamin D and parathyroid hormone to cardiac biomarkers and to left ventricular mass (from the Cardiovascular Health Study). American J Cardiol 111:418-424, 2013. PMCID: PMC3546140 

Published February 2013

Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.

Wander PL, Boyko EJ, Leonetti DL, McNeely MJ, Kahn SE, Fujimoto WY:  Change in visceral adiposity independently predicts a greater risk of developing type 2 diabetes over 10 years in Japanese Americans.  Diabetes Care 36:289-93, 2013. PMCID: PMC3554282 

Published February 2013

Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease.

de Boer IH, Sachs M, Hoofnagle AN, Utzschneider KM, Kahn SE, Kestenbaum B, Himmelfarb J:  Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease. Kidney Int 83:323-330, 2013. PMCID: PMC3509239

Published February 2013

P-selection glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction.

Lee WJ, Chait A, Kim F: P-selectin glycoprotein ligand-1: a cellular link between perivascular adipose inflammation and endothelial dysfunction. Diabetes 61:3070-3071, 2012. PMCID: PMC3501877 

Published December 2012

Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group: Circulating vitamin D metabolites and kidney disease in type 1 diabetes.

de Boer IH, Sachs MC, Cleary PA, Hoofnagle AN, Lachin JM, Molitch ME, Steffes MW, Sun W, Zinman B, Brunzell JD; Diabetes Control and Complication Trial/Epidemiology of Diabetes Interventions and Complications Study Research Group:  Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab 97:4780-4788, 2012. PMCID: PMC3513544

Published December 2012

Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry.

Laha TJ, Strathmann FG, Wang Z, de Boer IH, Thummel KE, Hoofnagle AN:  Characterizing antibody cross-reactivity for immunoaffinity purification of analytes prior to multiplexed liquid chromatography-tandem mass spectrometry. Clin Chem 58:1711-1716, 2012.  PMCID:  PMC3731945 

Published December 2012

Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation.

Umemoto T, Subramanian S, Ding Y, Goodspeed L, Wang S, Han CY, Teresa AS, Kim J,O'Brien KD, Chait A:  Inhibition of intestinal cholesterol absorption decreases atherosclerosis but not adipose tissue inflammation. J Lipid Res 53:2380-2389, 2012.  PMCID: PMC3466006 

Published November 2012

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT:  EGF receptor is required for KRAS-induced pancreatic tumorigenesis. Cancer Cell 22:304-317, 2012. PMCID: PMC3443395 

Published September 2012

Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: The Multi-Ethnic Study of Atherosclerosis (MESA).

Gutierrez OM, Katz R, Peralta CA, de Boer IH, Siscovick D, Wolf M, Diez Roux A,Kestenbaum B, Nettleton JA, Ix JH: Associations of socioeconomic status and processed food intake with serum phosphorus concentration in community-living adults: The Multi-Ethnic Study of Atherosclerosis (MESA). J Ren Nutr 22:480-489, 2012. PMCID: PMC3321388 

Published September 2012

Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice.

Kaiyala KJ, Morton GJ, Thaler JP, Meek TH, Tylee T, Ogimoto K, Wisse BE:  Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice. PLoS One 7:e41473, 2012. PMCID: PMC3425585 

Published August 2012

Common variation in fatty acid genes and resuscitation from sudden cardiac arrest.

Johnson CO, Lemaitre RN, Fahrenbruch CE, Hesselson S, Sotoodehnia N, McKnight B, Rice KM, Kwok PY, Siscovick DS, Rea TD. Common variation in fatty acid genes and resuscitation from sudden cardiac arrest. Circ Cardiovasc Genet 5:422-429, 2012. PMCID: PMC3422654 

Published August 2012

Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity.

Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST: Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. J Lipid Res 53:1376-1383, 2012. PMCID: PMC3371249 

Published July 2012

Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.

Ding Y, Subramanian S, Montes VN, Goodspeed L, Wang S, Han C, Teresa AS 3rd, Kim J,O'Brien KD, Chait A: Toll-like receptor 4 deficiency decreases atherosclerosis but does not protect against inflammation in obese low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 32:1596-1604, 2012.  PMCID:  PMC3748807 

Published July 2012

Proteomics investigations of HDL: challenges and promise.

Vaisar T:  Proteomics investigations of HDL: challenges and promise. Curr Vasc Pharmacol 10:410-421, 2012. (Review). PMCID:  PMC3685576 

Published July 2012

Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study.

Deo R, Katz R, Shlipak MG, Sotoodehnia N, Psaty BM, Sarnak MJ, Fried LF, Chonchol, M, de Boer IH, Enquobahrie, D, Siscovick D, Kestenbaum B: Vitamin D, parathyroid hormone, and sudden cardiac death: results from the cardiovascular health study. Hypertension 58:1021-1028, 2011. PMCID: PMC3337033 

Published December 2011