Chemistry Department
University of Washington
Seattle, WA 98195
E-mail: sxzheng@u.washington.edu
Tel: 1-206-543-5081
Postdoctoral Research
(Department of Chemistry, University of Washington,2005~ , advisor: Gabriele Varani)
- Predict the specificity and relative binding affinity of Protein-RNA interaction with the statistics potential.
- Set up the model to predict the relative binding affinity between TS and a series of inhibitors with MM-PBSA and QSAR approaches and design the new inhibitors for malaria disease. ( paper in preparation)
- Determine the complex structure of tau splicing regulatory element (SRE) and a stabilizer (Mitoxantrone) and provide the structure basis for designing the new drug to treat Tauopathies. ( paper in preparation)
- Determining the protein structure with NMR involved in SSGCID project
Doctoral Research
(Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 1999~2005, advisor: Hualiang Jiang)
- Build up a rapid and effective chemistry space filter to predict the drug-like properties of a molecule, which could be used in virtual screening and drug design.
- Explore the structure activity relationship between a series of bis-huperzine B and acetylcholinesterase by docking study.
Predict the relative binding affinity of a series of potassium channel blockers and protein-protein interaction, such as Nucleocapsid protein of SARS with human cyclophilin A and Neuregulin-b with ErbB4 , with MM-PBSA method.
Publications
1. Suxin Zheng, Timothy A. Robertson and Gabriele Varani A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J.; 2007; 274(24); 6378-6391
2. Hong Liu, Zhao-Bing Gao, Zhiyi Yao, Suxin Zheng, Yang Li, Weiliang Zhu, Xiaojian Tan, Xiaomin Luo, Jianhua Shen, Kaixian Chen, Guo-Yuan Hu, and Hualiang Jiang. Discovering Potassium Channel Blockers from Synthetic Compound Database by Using Structure-Based Virtual Screening in Conjunction with Electrophysiological Assay J. Med. Chem.; 2007; 50; 83-93
3. Xu-Chang He, Song Feng, Zhi-Fei Wang, Yufang Shi, Suxin Zheng, Yu Xia, Hualiang Jiang, Xi-can Tang and Donglu Bai, Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg. Med. Chem.; 2007; 15; 1394–1408
4. Hanjun Zou, Cheng Luo, Suxin Zheng, Xiaomin Luo, Weiliang Zhu, Kaixian Chen, Jianhua Shen, and Hualiang Jiang,.Molecular Insight into the Interaction between IFABP and PA by using MM-PBSA and Alanine Scanning Methods. J. Phys. Chem. B; 2007; 111; 9104-9113
5. Hongwei Jin, Suxin Zheng, Zhanli Wang, Cheng Luo, Jianhua Shen, Hualiang Jiang, Liangren Zhang and Lihe Zhang, Structural insights into the effect of isonucleosides on B-DNA duplexes using molecular-dynamics simulations. J. Mol. Model., 2006; 12(6); 781-791.
6. Suxin Zheng, Xiaoming Luo, Gang Chen, Weiliang Zhu, Kaixian Chen and Hualiang Jiang A New Rapid and Effective Chemistry Space Filter in Recognizing a Druglike Database. J. Chem. Inf. Model; 2005; 45(4); 856-862.
7. Gang Chen, Suxin Zheng, Xiaoming Luo, Jianhua Shen, Weiliang Zhu, Hualiang Jiang Focused Combinatorial Library Design Based on Structural Diversity, Druglikeness and Binding Affinity Score. J. Comb. Chem.; 2005; 7(3); 398-406.
8.Cheng Luo, Lingfei Xu, Suxin Zheng, Jianhua Shen, Hualiang Jiang and Kaixian Chen Computational Design Mutants of Neuregulin-b with Increased Binding Affinity and Selectivity to ErbB4. Proteins; 2005; 59(4);742-756.
9. Song Feng, Donglu Bai, Haiyan Zhang, Suxin Zheng, Xiaomin Luo, Hualiang Jiang Synthesis and Docking Studies of Alkylene-linked Dimers of Huperzine B, J. Med. Chem.; 2005; 48(3); 655-657.
10. Cheng Luo, Haibin Luo, Suxin Zheng, Chunshan Gui, Liduo Yue, Changying Yu, Tao Sun, Peilan He, Jing Chen, Jianhua Shen, Xiaomin Luo, Yixue Li, Hong Liu, Donglu Bai, Jingkang Shen, Yiming Yang, Fangqiu Li, Jianping Zuo, Rolf Hilgenfeld, Gang Pei, Kaixian Chen, Xu Shen,Hualiang Jiang Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A. Biochem. Biophys. Res. Commun., 2004; 321; 557–565.
11. Hong Liu, Yang Li, Mingke Song, Xiaojian Tan, Feng Cheng, Suxin Zheng, Jianhua Shen, Xiaomin Luo, Ruyun Ji, Jianmin Yue, Guoyuan Hu, Hualiang Jiang, and Kaixian Chen, Structure-Based Discovery of Potassium Channel Blockers from Natural Products: Virtual Screening and Electrophysiological Assay Testing, Chemistry & Biology, 2003; 10(11); 1103–1113.