View a complete list of publications on PubMed

Selected Publications

2009

• G. L. Olsen, M. F. Bardaro, D. C. Echodu, G. P. Drobny and Varani G Hydration-dependent dynamics in RNA JBNMR (2009) Sep;45(1-2):133-42

• A. Davidson, T. C. Leeper, Z. Athanassiou, K. Patora-Komisarska, J. Karn, J. A. Robinson and Varani G Simultaneous recognition of HIV-1 TAR RNA bulge and loop sequences by cyclic peptide mimics of Tat protein Proc. Natl. Acad. Sci. USA (2009) Jul 21;106(29):11931-6

• K. S. Godin, H. Walbott, N. Leulliot, H. van Tilbeurgh and Varani G the Box H/Aca snoRNP assembly factor Shq1 is a chaperone protein homologous to Hsp90 co-chaperones that interacts withn the Cbf5 enzyme J. Mol Biol. (2009) Jul 10;390(2):231-44

• S. Zheng, Y. Chen, C. Donahue, M. S. Wolfe and Varani G Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novatrone (mitoxantrone) Chem Biol 16 557-566 (2009)

• Bardaro MF Jr, Shajani Z, Patora-Komisarska K, Robinson JA, Varani G. How binding of small molecule and peptide ligands to HIV-1 TAR alters the RNA motional landscape. Nucl. Acids Res. 2009 (37): 1529-1540; Epub 2009 Jan 12. PMID: 19139066

2008

• Echodu D, Goobes G, Shajani Z, Pederson K, Meints G, Varani G, Drobny G. Furanose dynamics in the HhaI methyltransferase target DNA studied by solution and solid-state NMR relaxation. J Phys Chem B. 2008 Nov 6;112(44):13934-44. Epub 2008 Oct 10. PMID: 18844399

• Chen Y, Mandic J, Varani G. Cell-free selection of RNA-binding proteins using in vitro compartmentalization. Nucleic Acids Res. 2008 Nov;36(19):e128. Epub 2008 Sep 12. PMID: 18790803

• Gherghe CM, Shajani Z, Wilkinson KA, Varani G, Weeks KM. Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. J Am Chem Soc. 2008 Sep 17;130(37):12244-5. Epub 2008 Aug 19. PMID: 18710236

• Shajani Z, Varani G. 13C relaxation studies of the DNA target sequence for hhai methyltransferase reveal unique motional properties. Biochemistry. 2008 Jul 22;47(29):7617-25. Epub 2008 Jun 26. PMID: 18578505

• Reichow SL, Varani G. Nop10 is a conserved H/ACA snoRNP molecular adaptor. Biochemistry. 2008 Jun 10;47(23):6148-56. Epub 2008 May 13. PMID: 18473479

• Liu J, Begley D, Mitchell DD, Verlinde CL, Varani G, Fan E. Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chem Biol Drug Des. 2008 May;71(5):408-19. Epub 2008 Mar 27. PMID: 18373548

• Olsen GL, Echodu DC, Shajani Z, Bardaro MF Jr, Varani G, Drobny GP. Solid-state deuterium NMR studies reveal micros-ns motions in the HIV-1 transactivation response RNA recognition site. J Am Chem Soc. 2008 Mar 12;130(10):2896-7. Epub 2008 Feb 15. PMID: 18275190

• Deka P, Bucheli ME, Moore C, Buratowski S,Varani G . Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. J Mol Biol. 2008 Jan 4;375(1):136-50. Epub 2007 Sep 16. PMID: 18022637

2007

• S. Zheng, T. A. Robertson and G. Varani A knowledge-based potential function predicts the specificity and binding energy of RNA-binding proteins FEBS J. 274 6378-6391 (2007)
• P. Deka, M. E. Bucheli, C. Moore, S. Buratowski and G. Varani Structural Studies of the Interaction of the Yeast SR protein Npl3 with 3′-End Processing Sites J. Mol. Biol. 375 136-150 (2007)
• K. S. Godin and G. Varani How Arginine-rich domains coordinated mRNA maturation events RNA Biology 4 69-75 (2007)
• K. Moehle, Z. Athanassiou, R. L. A. Dias, G. Varani and J. A. Robinson Novel β−hairpin peptidomimetics inhibit bind to HIV Rev Response Element by mimicking a α-helical structure Angew Chemie 46 9101-9104 (2007)
• N. Leulliot, K. S. Godin, C. Hoareau-Aveilla, S. Quevillon-Cheruel, G. Varani, Y. Henry, H. Van Tilbeurgh The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p J. Mol. Biol. 371 1338-1353 (2007)
• Z. Shajani, G. Drobny and G. Varani Dynamic Changes in the RNA Binding Site for Human U1A Protein Observed by 13C NMR Relaxation Studies Biochemistry 46 5875-5883 (2007)
• B. Lunde, C. Moore and G. Varani RNA binding proteins; a modular design for efficient function Nature Rev. Mol. Cell Biol. 8 479-490 (2007)
• S. L. Reichow, T. Hamma, A. Ferre’ D’ Amare’ and G. Varani The Structure and function of Small Nucleolar Ribonucleoproteins Nucleic Acids Res. 35 1452-1464 (2007)
• Z. Shajani and G. Varani NMR studies of dynamics in RNA and DNA by 13C relaxation Biopolymers 86 345-362 (2007)
• A. Watters, P. Deka, C. Corrent, G. Varani, T. Sosnick and D. Baker The folding free energy landscape of Top7 is more complex than those of naturally occurring proteins Cell 128 613-624 (2007)
• G. Dantas, C. Corrent, S. L. Reichow, J. J. Havranek, Z. M. Eletr, B. Kuhlman, G. Varani, E. Merritt, D. Baker High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design J. Mol. Biol. 366 1209-1221 (2007)

• X. Qu, J. M. Pérez-Cañadillas,S. Agrawal, J. DeBaecke, G. Varani and C. Moore The C-terminal domains of vertebrate CstF-64 and its yeast orthologue Rna15 form a new structure critical for mRNA 3'-end processing. J. Biol. Chem. 282 2101-2115 (2007)

• Z. Athanassiou, R. L. A. Dias, K. Moehle, J. A. Robinson and G. Varani Novel β−hairpin peptidomimetics inhibitor of the BIV Tat protein binding to TAR with nM activity discovered from structure-based library design Biochemistry 46 741-751 (2007)