Links to articles follow references. Digital Object Identifier (doi) codes are provided when available. Abstract, Full-Text, and PDF versions are usually available from the online journal by following the DOI link. Access may be limited to journal subscribers; if you are unable to download an article, please contact us to request a reprint.
S. Zheng, T. Robertson, and G. Varani. A knowledge-based potential function predicts the specificity and relative binding energy of RNA-binding proteins. FEBS J 274(24) 6378--6391(2007) doi: 10.1111/j.1742-4658.2007.06155.x
Z. Shajani, G. Drobny and G. Varani. Binding of U1A Protein Changes RNA Dynamics As Observed by 13C NMR Relaxation Studies Biochemistry 46(20) 5875-5883 (2007) doi: 10.1021/bi602658x
A. Watters, P. Deka, C. Corrent, G. Varani, T. Sosnick and D. Baker The folding free energy landscape of Top7 is more complex than those of naturally occurring proteins Cell 128(3) 613-624 (2007) doi:10.1016/j.cell.2006.12.042
T. Robertson and G. Varani. An all-atom, distance-dependent scoring function for the prediction of protein-DNA interactions from structure. Proteins: Structure, Function and Bioinformatics 66(2) 359-374 (2007) doi:10.1002/prot.21162
P.A. Miller, Z. Shajani, G. Meints, D. Caplow, G. Goobes, G. Varani and G. Drobny. Contrasting Views of the Internal Dynamics of the HhaI Methyltransferase Target DNA Reported by Solution and Solid-State NMR Spectroscopy. Journal of the American Chemical Society 128 15970-15971 (2006) doi:10.1021/ja066329n
H.D. Cho, Y. Chen, G. Varani and A.M. Weiner. A model for C74 addition by CCA-adding enzymes: C74 addition, like C75 and A76 addition, does not involve tRNA translocation. Journal of Biological Chemistry 281 9801-9811 (2006) doi:10.1074/jbc.M512603200
Y. Chen, J. Fender, J. D. Legassie, M. B. Jarstfer, B. M. Tracy and G. Varani. Structure of stem-loop IV of Tetrahymena telomerase RNA. EMBO J. 25 3156-3166 (2006) doi:10.1038/sj.emboj.7601195
N. Dobson, N. Dantas, D. Baker and G. Varani. High-resolution structural validation of the computational redesign of human U1A protein. Structure 14 847-856 (2006) doi:10.1016/j.str.2006.02.011
S. Reichow and G. Varani. Structural biology - RNA switches function Nature 441 1054-1055 (2006) doi:10.1038/4411054a
Z. Shajani, P. Deka, and G. Varani. Decoding RNA motional codes. Trends Biochem. Sci. 31(8) 421-424 (2006) doi:10.1016/j.tibs.2006.06.002
Y. Chen and G. Varani. Protein families and RNA recognition. FEBS J. 272(9) 2088-2097 (2005) doi:10.1111/j.1742-4658.2005.04650.x
P. Deka, J.M.P. Cañadillas, P.K. Rajan, and G. Varani. Protein and RNA Dynamics Play Key Roles in Determining the Specific Recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. Journal of Molecular Biology 347(4) 719-733 (2005) doi:10.1016/j.jmb.2005.01.046
N. Dobson, G. Dantas and G. Varani. 1H, 13C and 15N resonance assignments of URNdesign, a computationally redesigned RRM protein. J. Biomol. NMR 33(2) 135-135 (2005) doi:10.1007/s10858-005-1928-4
T. Hamma, S.L. Reichow, G. Varani and A.R. Ferre-D'Amare. The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nature Structural and Molecular Biology 12 (12) 1101-1107 (2005) doi:10.1038/nsmb1036
T.C. Leeper and G. Varani.
The structure of an enzyme-activating fragment of human telomerase RNA.
RNA
11
394-403 (2005)
doi:10.1261/rna.7222505
PDB accession code
1Z31
Z. Shajani and G. Varani. C-13 NMR relaxation studies of RNA base and ribose nuclei reveal a complex pattern of motions in the RNA binding site for human U1A protein. Journal of Molecular Biology 349 (4) 699-715 (2005) doi:10.1016/j.jmb.2005.04.012
Z. Athanassiou, R.L.A. Dias, K. Moehle, N. Dobson, G. Varani and J.A. Robinson. Structural Mimicry of Retroviral Tat Proteins by Constrained β-Hairpin Peptidomimetics: Ligands with High Affinity and Selectivity for viral TAR RNA Regulatory Elements. JACS. 126 6906-6913 (2004) doi:10.1021/ja0497680
Y. Chen, T. Kortemme, T. Robertson, David Baker, and G. Varani. A new hydrogen-bonding potential for the design of protein-RNA interactions predicts specific contacts and discriminates decoys. Nucleic Acids Res. 32(17) 5147-5162 (2004) doi:10.1093/nar/gkh785
C. Detering and G. Varani. Validation of Automated Docking Programs for Docking and Database Screening against RNA Drug Targets J. Med. Chem. 47(17) 4188-4201 (2004) doi:10.1021/jm030650o
N. Leulliot, S. Quevillon-Cheruel, M. Graille, H. Tillbeurgh, T. Leeper, K. Godin, T. Edwards, S. Sigurdsson, N. Rozenkrants, R. Nagel, M. Ares Jr. and G. Varani. A new alpha-helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III. EMBO J. 23 2468-2477 (2004) doi:10.1038/sj.emboj.7600260
J.M.P. Cañadillas and G. Varani. Recognition of GU-rich polyadenylation regulatory elements by human Cstf-64 protein. EMBO J. 22 2821-2830 (2003) doi:10.1093/emboj/cdg259
T. C. Leeper, N. Leulliot and
G. Varani.
The solution structure of an essential stem-loop of human telomerase RNA.
Nucleic Acids Research
31(10)
2614-2621 (2003)
doi: 10.1093/nar/gkg351
PDB accession code 1OQ0
G. Varani and A. Ramos. Splicing Factor 1 in the Pocket. Structure 11 481-482 (2003)
G. Varani, Y. Chen and T.L. Leeper. NMR Studies of Protein-Nucleic Acid Interactions. Methods in Molecular Biology: Protein NMR Techniques. edited by K. Downing (2003)
T. Castrignanò, G. Chillemi, G. Varani and A. Desideri. Molecular Dynamics simulation of the RNA complex of a double-stranded RNA-binding domain reveals dynamic features of the intermolecular interface and its hydration. Biophys. J. 83 3542-3552 (2002) http://www.biophysj.org/cgi/content/abstract/83/6/3542
A.J. Collier, J. Gallego, R. Klinck, P.T. Cole, S.J. Harris, G.P. Harrison,F. Aboul-ela, G. Varani,, and S. Walker. A Conserved structure within the HCV IRES eiF3 binding site defines a new antiviral target. Nature Struct. Biol. 9 375-380 (2002) doi:10.1038/nsb785
J. Gallego and G. Varani. The Hepatitis C Internal Ribosome Entry Site, a new Target for Antiviral Research. Biochem. Soc. Trans. 30 140-146 (2002)
J. Greatorex, J. Gallego, G. Varani and A. Lever. Structure and stability of wild type and mutant RNA internal loops from the SL-1 domain of the HIV-1 packaging signal. J. Mol. Biol. 322 543-557 (2002) doi:10.1016/S0022-2836(02)00776-3
S. C. Shankaramma, G. Varani and F.H.T. Allain. How a Rotavirus Hijack the Human Protein Synthesis machinery. Nat. Struct. Biol. 9 158-160 (2002)
M. Allen and G. Varani. Nuclear Magnetic resonance Methods to Study Structure and Dynamics of RNA-Protein Complexes. Met. Enzym. 339 357-376 (2001)
J. Gallego and G. Varani. Targeting RNA with Small Molecule Drugs: Therapeutic promises and Chemical Challenges. Acc. Chem. Res. 34 836-843 (2001) doi:10.1021/ar000118k
N. Leulliot and G. Varani. Current Topics in RNA-Protein Recognition: Control of Specificity and Biological Function through Induced Fit and Conformation Capture. Biochemistry 40 7947-7956 (2001) doi:10.1021/bi010680y
J.M.P. Cañadillas and G. Varani. Recent Advances in RNA-Protein Recognition. Curr. Op. Struct. Biol. 11 53-58 (2001)
A. Ramos, P.Beyer and G. Varani. Determination of the Structure of the RNA Complex of a Double-Stranded RNA-Binding Domain from Drosophila Staufen Protein. Biopolymers 52 181-196 (2001)
G. Varani. Delivering Messages from the 3’-End. Proc. Natl. Acad. Sci. 98 4288-4289 (2001)
P. Bayer, L. Varani and G. Varani. New Methods for NMR Studies of Protein-RNA Complexes. Methods in Enzymology, RNA-Ligand Interactions Ed. by J. Abelson and D. Celander (2000)
A. Ramos, S. Grunert, M. Proktor, M. Bycroft, D. St Johnston and G. Varani. RNA Recognition by a Staufen Double-Stranded RNA-Binding Domain. EMBO J. 19 997-1009 (2000) doi:10.1093/emboj/19.5.997
A. Sachs and G. Varani. Eucaryotic translation initiation: there are (at least) two sides to every story. Nat. Struct. Biol. 7 356-361 (2000)
L. Varani, S. I. Gunderson, T. Mittermaier, L. Kay, D. Neuhaus, I. Mattaj and G. Varani. The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein. Nature Struct. Biol. 7 329-335 (2000) (Cover, News and Views). doi:10.1038/74101
L. Varani, M.G. Spillantini, M. Goedert and G. Varani. Structural Basis for Recognition of the RNA Major Groove in Tau Exon 10 Splicing Regulatory Element by Aminoglycoside Antibiotics. Nucleic Acids Res. 28 710-719 (2000) doi:10.1093/nar/28.3.710
G. Varani. RNA Structure. Encyclopedia of Molecular Biology McMillan, London (2000)
G. Varani and W.H. McClain. The GU Wobble Base Pair: a Fundamental Block of RNA Structure Crucial to RNA Function in Diverse Biological Systems. EMBO Reports 1 18-23 (2000)
M. Yasuda, J. Takamatsu, I. D’Souza, R. A. Crowther, T. Kawamata, M. Hasegawa, H. Hasegawa, M.G. Spillantini, S. Tanimukai, P. Poorkaj, L. Varani, G. Varani, T. Iwatsubo, M. Goedert, G.D. Schellenberg and C. Tanaka. A Novel Mutation in the Intron following Exon 10 of the Tau Gene in Familial Frontotemporal Dementia (FTD-Kumamoto). Ann. Neurol. 47 422-429 (2000)(with News and Views)
A. Zeffman, S. Hassard, A. Lever and G. Varani. Structure of a Conserved RNA Internal Loop from the HIV-1 Encapsidation Signal and Interaction with gag Protein. J. Mol. Biol. 297 877-893 (2000) doi:10.1006/jmbi.2000.3611
M. Afshar, C. Prescott and G. Varani. Structure-Based and Combinatorial Search for New RNA-Binding Drugs. Curr. Op. Biotech. 10 59-63 (1999)
L. Banci, I. Bertini, A. Rosato and G. Varani. Mytochondrial Cytochromes C: A Comparative Analysis. J. Biol. Inorg. Chemistry 4 824-837 (1999)
P. Bayer, L. Varani and G. Varani. Complexes by Residual Dipolar Coupling Analysis. J. Biomol. NMR 14 149-155 (1999)
K.Y. Chang, G. Varani, S. Bhattacharya, H. Choi and W. H. McClain. Correlation between RNA Deformability and tRNA Aminoacylation. PNAS 96 11764-11769 (1999) doi:10.1073/pnas.96.21.11764
K.Y. Chang, A. Zeffman and G. Varani. RNA Structure. Encyclopedya of Molecular Biology edited by Tom Creighton (1999)
A. Mittermaier, L. Varani, D. Muhandiram, L. E. Kay and G. Varani. Changes in sidechain and backbone dynamics identify determinants of specificity in RNA recognition by U1A. J. Mol. Biol. 294 967 (1999) (cover) doi:10.1006/jmbi.1999.3311
C. Richter, C. Griesinger, I. Felli, Paul T. Cole, G. Varani and H. Schwalbe.. Determination of Sugar Conformation in Large RNA Oligonucleotides from Analysis of Dipole, Dipole Cross-Correlated Relaxation by Solution NMR Spectroscopy. J. Biomol. NMR 15 241-250 (1999)
L. Varani, M. G. Spillantini, B. Ghetti, A. Klug, M. Goedert and G. Varani. Structure of Tau Exon 10 Splicing Regulatory Element RNA and Disruption by Frontotemporal Dementian and Parkinsonism Linked to Chromosome Mutations. PNAS 96 8229-8234 (1999) doi:10.1073/pnas.96.14.8229
G. Varani P. Bayer, P. Cole, A. Ramos and L. Varani. RNA Structure and RNA-Protein Recognition during Regulation of Eukaryotic Gene Expression. NATO ASI Series, RNA Biochemistry and Biotechnology 195-216 edited by J. Barciszewski and B.F.C. Clark (1999)
F. Aboul-ela and G. Varani. Recognition of HIV-1 TAR RNA by Tat Protein and Tat-derived Peptides. J. Mol. Structure (Theochem) 423 29-40 (1998)
P.W.A. Howe, F.H.T. Allain, G. Varani and D. Neuhaus. Determination of the NMR Structure of the Complex between U1A Protein and its RNA Polyadenylation Inhibition Element. J. Biomol. NMR 11 59-84 (1998)
J. Karn, N.J. Keen, M.J. Churcher, F. Aboul-Ela, G. Varani, F. Hamy, E.R. Felder, G. Heizmann and T. Klimkait. The HIV Tat-TAR Interaction, a Novel Target for Drug Discovery. Pharmacochemistry Library Van der Goot (Ed.) Elsevier (1998)
S.R. Price, C. Oubridge, G. Varani and K. Nagai. Preparation of RNA-Protein Complexes for X-Ray Crystallography and NMR. RNA-Protein Interaction: Practical Approach. Ed. by C. Smith, Oxford University Press (1998)
A. Ramos and G. Varani. A New Method to Detect Long-Range Protein-RNA Contacts: NMR Detection of Electron-Proton Relaxation Induced by Nitroxide Spin-Labelled RNA. J. Am. Chem. Soc. 120 10992-10993 (1998) doi:10.1021/ja982496e
G. Varani and K. Nagai. RNA Recognition by RNP Proteins during RNA Processing and Maturation. Ann. Rev. Biophys. Biomol. Struct. 27 407-445 (1998) doi:10.1146/annurev.biophys.27.1.407
L. Varani, A. Ramos, P.T. Cole, D. Neuhaus and G. Varani. RNA-Protein Interactions and Protein-Protein Interactions during Regulation of Eukaryotic Gene Expression. J. Korean Magn. Reson. Soc. 2 152-157 (1998)
F.H.T. Allain, P.W.A. Howe, D. Neuhaus and G. Varani. Structural Basis for the RNA-Binding Specificity of Human U1A Protein. EMBO J. 16 5764-5774 (1997) doi:10.1093/emboj/16.18.5764
F.H.T. Allain and G. Varani. How Accurately and Precisely can RNA Structure be determined by NMR? J. Mol. Biol. 267 338-351 (1997)
K.Y. Chang and G. Varani. Nucleic Acids Structure and Recognition. Nature Struct. Biol. 4 854-859 (1997) http://www.nature.com/nsmb/wilma/v4n10.875823718.html
F. Hamy, G. Heizmann, E. Felder, G. Varani, F. Aboul-Ela, J. Lazdins, M. Walker, J. Karn and T. Klimkait. An Inhibitor of the Tat/TAR RNA Interaction that Effectively Suppresses HIV Replication. PNAS 94 3548-3553 (1997) doi:10.1073/pnas.94.8.3548
A. Ramos, C.C. Gubser and G. Varani. Recent NMR Structures of RNA and its Complexes with Drugs, Peptides and Proteins. Curr. Op. Struct. Biol. 7 317-323 (1997)
A. Ramos and G. Varani. Structure of the Acceptor Stem of E.coli tRNAAla: Role of the G3·U70 Base Pair in Synthetase Recognition. Nucleic Acids Res. 25 2083-2090 (1997) (cover)
G. Varani. A Cap for All Occasions. Structure 5 855-858 (1997)
G. Varani. RNA-Protein Recognition during RNA Processing and Development. The Many Faces of RNA. Ed. by D. Eggleston, C. Prescott and N. Pearson, Academic Press (1997)
G. Varani. RNA-Protein Intermolecular Recognition. Acc. Chemical Res. 30 189-195 (1997)
F. Aboul-ela, J. Karn and G. Varani. The Structure of HIV-1 TAR RNA in the Absence of Ligands Reveals a Novel Conformation of the Trinucleotide Bulge. Nucleic Acids Res. 24 3974-3981 (1996)
F.H.T. Allain, C.C. Gubser, P.W.A. Howe, K. Nagai, D. Neuhaus and G. Varani. RNP Interaction Specificity Determined by RNA Folding during Complex Formation. Nature 380 646-650 (1996)
J. Avis, F.H.T. Allain, P.W.A. Howe, G. Varani, D. Neuhaus and K. Nagai. Solution Structure of the N-terminal RNP Domain of U1A Protein: The Role of C-terminal Residues in Structure Stability and RNA Binding. J. Mol. Biol. 257 398-411 (1996) doi:10.1006/jmbi.1996.0171
F.H.T. Allain, C.C. Gubser, P.W.A. Howe, K. Nagai, D. Neuhaus and G. Varani. RNP Interaction Specificity Determined by RNA Folding during Complex Formation. Nature 380 646-650 (1996) doi:10.1016/S0022-2836(02)00776-3
C.C. Gubser and G. Varani. Structure of the Polyadenylation Regulatory Element of the Human U1A pre-mRNA 3'-Untranslated Region and Interaction with the U1A Protein. Biochemistry 35 2253-2267 (1996)
G. Varani, F. Aboul-ela and F.H.T. Allain. NMR Investigation of RNA Structure. Prog. NMR Spectroscopy 29 51-127 (1996) doi:10.1016/0079-6565(96)01028-X
F. Aboul-ela, J. Karn and G. Varani. The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat Protein. J. Mol. Biol. 253 313-332 (1995) (cover)
F. Aboul-ela and G. Varani. Novel Techniques in Nuclear Magnetic Resonance for Nucleic Acids. Curr. Op. Biotech. 6 89-95 (1995)
F.H.T. Allain and G. Varani. Structure of the P1 Helix from Group I Self Splicing Introns. J. Mol. Biol. 250 333-353 (1995) (cover)
F.H.T. Allain and G. Varani. Divalent Metal Ion Binding to a Conserved Wobble Pair Defining the Upstream Site of Cleavage of Group I Self-Splicing Introns. Nucleic Acids Res. 23 341-350 (1995)
G. Varani, F. Aboul-ela, F.H.T. Allain and C.C. Gubser. Novel Three-Dimensional 1H-13C-31P Triple Resonance Experiments for Sequential Backbone Correlations in Nucleic Acids. J. Biomol. NMR 5 315-320 (1995)
G. Varani. Exceptionally Stable Nucleic Acid Hairpins. Ann. Rev. Biophys. Biomol. Structure 24 379-404 (1995)
P.W.A. Howe, K. Nagai, D. Neuhaus and G. Varani. NMR Studies of U1 snRNA Recognition by the N-Terminal RNP Domain of the Human U1A Protein. EMBO J. 13 3873-3881 (1994)
G. Varani and A. Pardi. RNA Structure in RNA-Protein Interactions. Eds. I. Mattaj and K. Nagai (Oxford University Press)(1994)