Brain Imaging

The functional blood flow networks of the entire brain in mice were imaged by UHS-OMAG in vivo. Because of its depth-resolved imaging capability, OMAG is capable of providing simultaneous imaging of microcirculations within (A) the meninges and (B) the cortex of a mouse. SS, sagittal suture; ACS, anterior coronal suture; PCS, posterior coronal.

Representative meningeal microvascular network during thrombus formation induced by FeCl3.  (A) is a sketch of the mouse skull; the red box indicates the region imaged by UHS-OMAG and the dotted line indicates the place where the FeCl3 was topically applied. (B) shows serial OMAG images of  microvascular occlusion and blood flow changes, indicating development of thrombus for the region shown in (A). Numbers in the bottom left corner of each panel are minutes after application of FeCl3. (C) is a vascular sketch based on the vascular occlusion sequence in (B), where four vessels are indicated in different colors, the numbers indicate their occlusion sequence and the arrows show four regions of interest in which blood flow will be quantified. 

OMAG is capable of providing (a) retinal microvasculature maps within a large field of view, and (b) the corresponding color depth-encoded retinal vasculature map (the red, green and blue represent the GCL, IPL and OPL respectively).

High resolution OMAG retinal vasculature network images reveal clear details of the vessel interconnections, particularly for the capillary blood vessels. (a), (b) and (c) present the blood vessel networks located at the GCL, IPL and OPL layers, respectively. (d) is the false color depth-encoded blood vessel images by combining together the vessels presented in (a), (b) and (c). The red, green and blue are corresponding to GCL, IPL and OPL respectively.

Retina Imaging

Optical Microangiography of Microcirculations within tissue beds in vivo

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