Selected publications (in chronological order)

Cai A, Wise PM 1996 Age-related changes in the diurnal rhythm of corticotropin releasing hormone gene expression in the paraventricular nuclei. Amer J Physiol 270:E238-243

Scarbrough K, Harney JP, Wise PM 1996 Acute effects of antisense antagonism of a single peptide neurotransmitter in the circadian clock. Amer J Physiol 270:R283-288

Wise PM, Krajnak KM, Kashon ML 1996 Menopause: Aging of multiple pacemakers. Science 273:67-70

Harney JP, Scarbrough K, Rosewell KL, Wise PM 1996 In vivo antisense antagonism of vasoactive intestinal peptide in the suprachiasmatic nucleus causes aging-like changes in the estradiol-induced LH and prolactin surge. Endocrinology 137:3696-3701

Cai A, Wise PM 1996 Age-related changes in light-induced jun-B and jun-D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus. J Biol Rhythms 11:284-290

Wise PM, Krajnak KM, Kashon ML 1996 The advent of menopause. Science 274:18-19

Cai A, Lloyd JM, Lehman MN, Wise PM 1997 Transplantation of fetal suprachiasmatic nuclei into middle-aged rats restores diurnal fos expression in the host. Amer J Physiol 272:R422-428

Hinkle DA, Baldwin SA, Scheff SW, Wise PM 1997 GFAP and S100b expression in response to mild cortical contusion. J Neurotrauma 14:729-738

Niu H, Hinkle DA, Wise PM 1997 Dexamethasone regulates basic fibroblast growth factor, nerve growth factor and S100b expression in cultured hippocampal astrocytes. Mol Brain Res 51:97-105

Cai A, Scarbrough K, Hinkle DA, Wise PM 1997 Transplantation of fetal hypothalamic tissue containing the suprachiasmatic nucleus partially restores the diurnal rhythm of corticotropin releasing hormone gene expression and proopiomelanocortin gene expression in aging rats. Amer J Physiol 42:R1764-1770

Hinkle DA, Harney JP, Cai A, Hilt DC, Yarowsky PJ, Wise PM 1998 FGF-2 and IL-1beta regulate S100b expression in cultured astrocytes. Neuroscience 82:33-41

Krajnak K, Kashon M, Rosewell KL, Wise PM 1998 Sex differences in the daily rhythm of vasoactive intestinal polypeptide but not arginine vasopressin mRNA.  Endocrinology 139:4189-4196

Krajnak K, Kashon M, Rosewell KL, Wise PM 1998 Aging alters the rhythmic expression of vasoactive intestinal polypeptide (VIP) mRNA but not arginine vasopressin (AVP) mRNA. J Neurosci 18:4767-4774

Dubal D, Pettigrew LC, Kashon M, Ren JM, Finklestein SP, Rau SW, Wise PM 1998 Estradiol protects against ischemia-induced brain injury. JCBFM 18:1253-1258

Dubal DB, Shughrue PJ, Wilson ME, Merchenthaler I, Wise PM 1999 Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J Neurosci 19:6385-6393

McShane TM, Wilson ME, Wise PM 1999 Effects of aging and life-long moderate caloric restriction on levels of neuropeptide Y, proopiomelanocortin and galanin mRNA. J Gerontol 54:B14-B21

Wilson ME, Dubal DB, Wise PM 2000 Estradiol protects injury-induced cell death in cortical explant cultures: a role for estrogen receptors.  Brain Res 873:235-242

Smith MJ, Jennes L, Wise PM 2000 Localization of the VIP2 receptor protein on GnRH neurons in the female rat.  Endocrinology 141:4317-4320

Wise PM, Dubal DB 2000 Estradiol protects against ischemic brain injury in middle-aged rats.  Biol Reprod 63:982-985

Dubal DB, Wise PM 2001 Neuroprotective effects of estradiol in middle-aged female rats.  Endocrinology 142:43-48

Krajnak K, Rosewell KL, Wise PM 2001 Fos induction in gonadotropin releasing hormone (GnRH) neurons receiving vasoactive intestinal polypeptide (VIP) innervation is reduced in middle-aged female rats.  Biol Reprod 64:1160-1164

Dubal DB, Zhu H, Yu J, Rau SW, Shughrue PJ, Merchenthaler I, Kindy MS, Wise PM 2001 Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury.  Proc Natl Acad Sci, USA 98:1952-1957

Smith MJ, Wise PM 2001 Localization of kappa-opioid receptors in oxytocinergic neurons in the paraventricular and supraoptic nuclei.  Brain Res 898:162-165

Smith MJ, Wise PM 2001 Neurotensin gene expression increases during proestrus in the rostral preoptic nucleus: potential for direct communication with GnRH neurons.  Endocrinology 142:3006-3013

Le W-W, Wise PM, Hoffman GE 2001 Parallel declines in fos activation of the medial anteroventral periventricular (AVPv) nucleus and LHRH neurons in middle-aged rats.  Endocrinology 142:4976-4982

Dubal DB, Wise PM 2001 Neuroprotective effects of estradiol in middle-aged female rats.  Endocrinology 142:43-48

Wise PM, Dubal D, Wilson ME, Rau SW, Liu Y 2001 Estradiol: A trophic and protective factor in the adult brain.  Front Neuroendocrinol 22:33-66

Krajnak K, Rosewell KL, Wise PM 2001 Fos induction in gonadotropin releasing hormone (GnRH) neurons receiving vasoactive intestinal polypeptide (VIP) innervation is reduced in middle-aged female rats.  Biol Reprod 64:1160-1164

Smith MJ, Wise PM 2001 Immunohistochemical localization of kappa-opioid receptors in oxytocin neurons in the rat paraventricular and supraoptic nuclei.  Brain Res 898:162-165

Wise PM, Dubal DB, Wilson ME, Rau SW, Bottner M 2001 Neuroprotective effects of estrogen: new insights into mechanisms of action.  Endocrinology 142:969-973

Wilson ME, Liu Y, Wise PM 2002 Estradiol enhances Akt activation in cortical explant cultures following neuronal injury.  Mol Brain Res 102:88-94

Cashion AB, Smith MJ, Wise PM 2003 The morphometry of astrocytes in the rostral preoptic area (rPOA) exhibits a diurnal rhythm on proestrus: relationship to the LH surge and effects of age.  Endocrinology 144:274-280

Bellino FL, Wise PM 2003 Non-human primate models of menopause workshop.  Biol Reprod 68:10-13

Rau SW, Dubal DB, Böttner M, Wise PM 2003 Estradiol differentially regulates c-Fos after focal cerebral ischemia.  J Neurosci  23:10487-10494

Rau SW, Dubal DB, Böttner M, Gerhold LM, Guttmann RP, Wise PM 2003 Estradiol attenuates markers of programmed cell death after focal cerebral ischemia.  J Neurosci 23:11420-11426

Wise PM 2003 Neuroprotective actions of estradiol in brain injury.  Endocrine 21:11-15

Turgeon JL, McDonnell DP, Martin KA, Wise PM 2004 Hormone therapy: physiological complexity belies therapeutic simplicity.  Science 304:1269-1273

Cashion AB, Smith MJ, Wise PM 2004 Glutamic acid decarboxylase 67 (GAD67) gene expression in the rostral preoptic area changes during the estrous cycle and with age.  J Neuroendocrinol 16:711-716

Gerhold LM, Rosewell KL, Wise PM 2005 Suppression of vasoactive intestinal polypeptide in the suprachiasmatic nucleus leads to aging-like changes in cAMP rhythms and activation of gonadotropin releasing hormone neurons.  J Neurosci 25:62-67

Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S 2005 Are estrogens protective or risk factors in brain injury and neurodegeneration?  Re-evaluation after the Women’s Health Initiative.  Endocrine Rev 26:308-312

Böttner M, Dubal DB, Rau SW, Suzuki S, Wise PM 2006 Activin A gene expression increases after stroke injury. J Neuroendocrinol 18:97-103

Suzuki S, Brown CM, Wise PM 2006 Mechanisms of neuroprotection by estrogen.
Endocrine 29:209-215

Gerhold LM and Wise PM 2006 Vasoactive intestinal polypeptide regulates dynamic changes in astrocyte morphometry: Impact on gonadotropin releasing hormone neurons. Endocrinology 147:2197-220

Dubal DB, Rau SW, Shughrue PJ, Zhu H, Yu J, Cashion AB, Suzuki S, Gerhold LM, Böttner M, Dubal SB, Merchenthaler I, Kindy M, Wise PM 2006 Differential modulation of estrogen receptors (ERs) in ischemic brain injury: a novel role for ER in estradiol-mediated protection against programmed cell death. Endocrinology 147:3076-3084

Turgeon JL, Mendelsohn M, Carr M, Maki PL, Wise PM 2006 Complex actions of sex steroids in adipose, the cardiovascular system and brain: insights from basic science and clinical studies.  Endocrine Rev  27:575-605

Suzuki S, Gerhold LM, Böttner M, Rau SW, DelaCruz, CD, Yang E, Zhu H, Yu J, Cashion AB, Kindy MS, Merchenthaler I, Gage FH, Wise PM  2007 Estradiol enhances neurogenesis following ischemic brain injury through estrogen receptors alpha and beta.   J Comp Neurol 500:1064-1075

Suzuki S, Brown CM, Dela Cruz, CD, Yang E, Bridwell DA, Wise PM 2007 Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and anti-inflammatory actions.  Proc Natl Acad Sci, USA 104:6013-6018

Jelks KAB, Wylie RL, Floyd CL, McAllister AK, Wise PM 2007 Estradiol targets synaptic proteins to induce glutamatergic synapse formation in cultured hippocampal neurons: critical role of estrogen receptor-alpha. J Neurosci 27:6903-6913