Anesthesiology & Pain Medicine >> Research >> Labs >> Terman Lab
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Dr. Gregory W. Terman

Terman Laboratory
Gregory W. Terman, MD, PhD

  • Professor & Director of Pain Medicine Research, Department of Anesthesiology and Pain Medicine
  • Professor, Graduate Program in Neurobiology & Behavior


  • Neurochemical changes that take place in the neonatal rat spinal cord following repeated opiate administration as a cellular model of opiate analgesic tolerance
  • Effects of memantine when combined with opiate medications to see whether it can increase the effectiveness of opiates for pain after surgery and reduce the side effects caused by opiates (e.g., sedation, nausea, itching)

Honors and Awards

  • 1980—1981 University of California, Los Angeles, University Fellowship
  • 1981—1982 NRSA NIMH Predoctoral Trainee
  • 1983—1984 NRSA NIMH Predoctoral Trainee
  • 1992 NRSA Anesthesia Research and Training Grant

Current Memberships

  • American Association for the Advancement of Science
  • American Pain Society
  • American Society of Addiction Medicine
  • American Society of Anesthesiologists
  • American Society for Regional Anesthesia
  • International Association for the Study of Pain
  • International Anesthesia Research Society
  • Society for Neuroscience
  • Washington State Medical Association
  • Washington State Society of Anesthesiologists
  • Western Pharmacology Society

Current Funding

Selected Publications

  • Terman, GW: Kappa opioids inhibit neurotransmission in Lamina I of the spinal cord following sensitization, submitted.
  • Eastman, CL.,Zeng, J, Cheong, PY and Terman, GW: Kappa opioids modulate Lamina I neurotransmission in morphine- tolerant but not in morphine-naïve spinal slices, submitted.
  • Grande, LA, O'Donnell, B, Fitzgibbon, D, Terman GW: Ultra-low Dose Ketamine and Memantine for the Treatment of Complex Pain in an Opioid-Tolerant Oncology Patient, Anesthesia and Analgesia, 107:1380-3, 2008.
  • Thomson, LM, Terman, GW, Zeng, J, Lowe, J, Chavkin, C, Hermes, SM, Hegarty, DM and Aicher,SA: Decreased Substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. J Pain, 9:11-19, 2008.
  • Zeng J, Thomson LM, Aicher SA, Terman GW. : Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats. J Neurosci. 2006 Nov 15;26(46):12033-42.
  • Thomson LM, Zeng J, Terman GW.: Differential effect of glutamate transporter inhibition on EPSCs in the morphine naive and morphine tolerant neonatal spinal cord slice. Neurosci Lett. 2006 Oct 16;407(1):64-9.
  • Thomson LM, Zeng J, Terman GW.: An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. Neuroscience. 2006 Sep 1;141(3):1489-501.
  • Sullivan M, Terman GW, Peck B, Correll DJ, Rich B, Clark WC, Latta K, Lebovits A, Gebhart G; American Pain Society Ethics Committee: APS position statement on the use of placebos in pain management. J Pain. 2005 Apr;6(4):215-7.
  • Xu, M., Petraschka, M., McLaughlin, J.P., Westenbroek, R.E., Caron, M.G., Lefkowitz, R.G., Czyzyk, T.A., Pintar, J.E., Terman, G.W. and Chavkin, C.: Neuropathic Pain Activates the Endogenous Kappa Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance. J.Neurosci., 24: 4576-4584, 2004.
  • Terman, G.W., Jin, W., Cheong, Y-P, Caron, M.G., Lefkowitz, R.J. and Chavkin, C.: G-Protein receptor kinase 3 (GRK3) mediates analgesic tolerance but not withdrawal, British Journal of Pharmacology, 141:55-64, 2004.
  • Terman, G.W., Eastman, C.L. and Chavkin, C.: Mu opiates inhibit LTP induction in the spinal cord slice, J. Neurophysiology, 85: 485-494, 2001.
  • Terman, G.W. and Bonica, J.J.: Anatomic and Physiologic Basis of Nociception: Spinal Mechanisms and Their Modulation, in Loeser, J, Butler, S, Chapman, R, and Turk, D, (Eds.): Bonica's Management of Pain. Pp. 73-153. New York, Williams and Wilkins, 2000.
  • Terman, G.W., Jin, W., Gunther, J., Caron, M., Lefkowitz, R., Chavkin, C.: G-protein coupled receptor kinase (GRK3) mediates mu opiate analgesic tolerance, Soc. Neurosci. Abstr., 26: 112, 2000.
  • Jin, W., Assi, A.-A., Eastman, C., Terman, G.W., Chavkin, C.: Synaptic plasticity contributes to opioid tolerance in vitro, Soc. Neurosci. Abstr., 26: 636, 2000.
  • Varnado-Rhodes, Y., Gunther, J., Terman, G.W., Chavkin, C.: Mu-opioid analgesia and analgetic tolerance in two different mouse strains: C57BL/6 and 129/SvJ mice. Proc. West. Pharmacol. Soc., 43: 15-17, 2000.
  • Rogalski, S.L.., Appleyard, S., Patillo, A., Terman, G.W., Chavkin, C.: Growth factor signalling can be mediated by Ion Channel Phosphorylation, J. Bio. Chem., 275:25082-8, 2000.
  • Terman, G.W., Drake, C.T., Simmons, M.L., Milner,T.A. and Chavkin, C.: Opioid modulation of recurrent excitation in the hippocampal dentate gyrus, J Neurosci., 20:4379-4388, 2000.
  • Bausch,S.B., Esteb, T.M., Terman, G.W., Chavkin, C.: Administered and endogenously released kappa opioids decrease pilocarpine-induced seizures and seizure-induced histopathology: J. Pharmacol.Exp. Therap., 284:1147-1155, 1998.
  • Simmons, M.L., Terman, G.W., and Chavkin, C.: Spontaneous excitatory currents and kappa opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J. Neurophysiology, 78:1860-1868, 1997.
  • Rapp, S.E., Egan, K.J., Ross, B.K., Wild, L.M., Terman. G.W., and Ching, J.M.: Multidimensional comparison of morphine and hydromorphone patient controlled analgesia. Anesth. Analg. 82:1043-1048, 1996.
  • Jin, W., Terman, G.W., and Chavkin, C.: Kappa opioid receptor tolerance in the guinea pig hippocampus. J Pharmacol Exp Therap, 281: 123-128, 1997.
  • Simmons, M.L., Terman, G.W., Gibbs, S.M., and Chavkin, C.: L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron 14:1265-12, 1995.
  • Simmons, M.L., Terman, G.W.., Drake, C.T., and Chavkin, C.: Inhibition of glutamate release by presynaptic kappa opioid receptors in the guinea pig dentate gyrus. J. Neurophysiol. 72:1697-1705, 1994.
  • Drake, C.T., Terman. G.W., Simmons, M.L., Milner, T.A., Kunkel, D.D., Schwartzkroin, P.A., and Chavkin, C.: Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. J. Neurosci. 14:3736-3750, 1994.
  • Terman. G.W., Wagner, J.J., and Chavkin, C.: Endogenous and exogenous kappa opioids inhibit induction of long-term potentiation in the dentate gyrus of the guinea pig hippocampus. J. Neurosci. 14:4740-474 1994.
  • Wagner, J.J., Terman, G.W., and Chavkin, C.: Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus. Nature, 363:451-454, 1993.
  • Pechnick, R.N., and Terman, G.W.: The role of opiate receptors in the potentiation of pentobarbital sleeping time by the acute and chronic administration of opiates. Neuropharmacology 26:1589-1593, 1987.
  • Terman, G.W., Morgan, M.J., and Liebeskind, J.C.: Opioid and nonopioid stress analgesia from cold water swim: Importance of stress severity. Brain Res. 372:167-171, 1986.
  • Terman, G.W., Lewis, J.W., and Liebeskind, J.C.: Two opioid forms of stress analgesia: Studies of tolerance and cross-tolerance. Brain Res. 368:101-106, 1986.
  • Foong, F.W., Terman, G.W., and Duggan, A.W.: Methysergide and spinal inhibition from electrical stimulation in periaqueductal grey. Eur. J. Pharmacol. 116:239-248, 1985.
  • Terman, G.W., Penner, E.R., and Liebeskind, J.C.: Stimulation-produced and stress-induced analgesia: Cross. tolerance between opioid forms. Brain Res. 360:374-378, 1985.
  • Moskowitz, A.S., Terman, G.W., and Liebeskind, J.C.: Stress-induced analgesia in the mouse: strain comparisons. Pain 23:67-72, 1985.
  • Terman, G.W., Shavit, Y., Lewis, J.W., Cannon, J.T., and Liebeskind, J.C.: Intrinsic mechanisms of pain inhibition and their activation by stress. Science 226:1270-1277, 1984.
  • Terman, G.W., Lewis, JW., and Liebeskind, J.C.: Opioid and nonopioid mechanisms of stress analgesia: Lack of cross-tolerance between stressors. Brain Res. 260:147-150, 1983.