Suggestions For Peri-Procedural Management Of Edoxaban


CrCl T 1/2

Time of last dose of edoxaban prior to procedure

(peri-procedural bridging is generally not required)

    Standard Risk of Bleeding

High Risk of Bleeding1

(major surgery, spinal puncture or placement of spinal/epidural catheter, and other situations in which complete hemostasis is required

1ASRA 4th edition 2018: hold 72 hours for all patients prior to neuraxial procedures, without regard for influence of renal function on half-life and clearance

80-95 ml/min      10-14 hrs at least 24 hours at least 48 hours
50-79 ml/min 10-14 hrs
30-49 ml/min 10-14 hrs       
15-29 ml/min 17 hrs at least 48 hours at least 72 hours
< 15 ml/min unknown edoxaban assay is currently unavailable at UWMedicine to determine absence of drug effect