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Our studies have revealed a significant
correlation between the average sequence seqaration between contacting residues
in the native state (contact order) and the folding rate of simple, single domain proteins. For
more information you may view the
[Full Text PDF]
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This website determines the contact order by either uploading a PDB file
supplied by the user or retrieving the PDB file from the
Protein Data Bank
by ftp. The uploaded file must follow the standard PDB file format.
More time is usually required to retrieve a PDB file from the Protein Data Bank.
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Plaxco, K. W., Simons, K. T., and Baker, D. (1998).
Contact order, transition state placement, and the refolding rates of single domain proteins.
J. Mol. Biol. 277, 985-994. [Full Text PDF]
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