The FDA approval clears the way for a Phase I trial of volunteers to confirm whether the drug, which demonstrated significant hearing protection in animal models, is safe for humans. The drug represents more than a decade of exploration by UW scientists Ed Rubel and David Raible. Click here for a link to the news release http://newsroom.uw.edu/print/1797
Dr Bermingham-McDonogh received an Institute for Stem Cell and Regenerative Medicine Innovation Pilot Award for her grant entitled "Determining the pattern of gene expression in support cells that defines support cell competence to generate hair cells in the mouse crista."
A new NIH grant has been awarded to Dr. Zipora Yablonka-Reuveni. The project is driven by her lab's novel discovery of a secondary myogenic lineage in extraocular muscles (EOMs) that specifies the EOM orbital layer and may contribute to the unique sparing of this muscle group in Duchenne muscular dystrophy and in dystrophin-null animal models. The immediate aim is to establish and evaluate several Cre/loxP mouse models for the impact on the emergence of the EOM secondary myogenic lineage. The results could contribute to breakthrough findings toward refining our understanding of mechanisms involved in eye muscle functional specification and the sparing of the EOMs in muscular dystrophy.