Wong, Rachel | Department of Biological Structure

Professor

Chair

Research Focus:

Development and regeneration of synaptic circuits in the vertebrate retina

Our lab is interested in neuronal circuit assembly in development, circuit disassembly in degeneration and circuit reassembly upon cellular regeneration. Our studies are based on the vertebrate retina of zebrafish and mice. We apply a diversity of approaches including in vivo and in vitro confocal and multiphoton imaging, electron microscopy, transgenic methods and electrophysiology to investigate neuronal structure, function and connectivity in normal and perturbed retinas.

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Publications [from PubMed]

Establishing Wiring Specificity in Visual System Circuits: From the Retina to the Brain.
Zhang C, Kolodkin AL, Wong RO, James RE
Annual review of neuroscience. 2017 Jul; 40 : 395-424
Cellular and Circuit Mechanisms Shaping the Perceptual Properties of the Primate Fovea.
Sinha R, Hoon M, Baudin J, Okawa H, Wong RO, Rieke F
Cell. 2017 Jan; 168 3: 413-426.e12
Mismatch of Synaptic Patterns between Neurons Produced in Regeneration and during Development of the Vertebrate Retina.
D'Orazi FD, Zhao XF, Wong RO, Yoshimatsu T
Current biology : CB. 2016 Sep; 26 17: 2268-79
Glutamatergic Monopolar Interneurons Provide a Novel Pathway of Excitation in the Mouse Retina.
Della Santina L, Kuo SP, Yoshimatsu T, Okawa H, Suzuki SC, Hoon M, Tsuboyama K, Rieke F, Wong ROL
Current biology : CB. 2016 Aug; 26 15: 2070-2077
Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells.
Hoon M, Sinha R, Okawa H, Suzuki SC, Hirano AA, Brecha N, Rieke F, Wong RO
Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct; 112 41: 12840-5

Email:

wongr2@u.washington.edu

Phone:

(206) 616-3275

Address:

H-514 HSB

Website:

Website