The Bush Lab is a research group in the Department of Chemistry and the Biological Physics, Structure & Design Program at the University of Washington. Our research focuses on the development and application of mass spectrometry and ion mobility spectrometry techniques to elucidate the structures and assembly of protein complexes and subcellular machines.
Congratulations to Daniele Canzani, who was recently awarded a Graduate Student Merit Fellowship. This award recognizes his accomplishments in research and coursework. We all thank the support of Mickey and Karen Schurr, who have endowed this award.
Congratulations to Anna Bakhtina, who has accepted an offer to enter the Ph.D. program in Genome Sciences at the University of Washington. As an undergraduate student researcher in the Bush Lab, Anna investigated the effects of drift gas selection on the ion mobility of petroleum and biomolecular ions. We are excited to follow her research …
Congratulations to Evan Hubbard, who has accepted an offer to enter the Ph.D. program in Chemistry at the University of California, Riverside. As an undergraduate student researcher in the Bush Lab, Evan investigated fundamental aspects of electrospray ionization in the context of native mass spectrometry. We are excited to follow his research at UCR!
Most proteins, particularly those that accomplish complicated tasks, form assemblies with other proteins and molecules that are critical to their function. Established structural biology tools are most effective for highly purified samples that have limited conformational variability, which makes it challenging to apply those methods to capture a systems-wide understanding of the structures, interactions, and dynamics that are present under different cellular conditions. The Bush Lab develops and applies mass spectrometry based techniques that are fast, sensitive, and tolerant of heterogeneity for characterizing the native structures of biological assemblies.