Rae Eaton earned B.A degrees in Chemistry and Biochemistry at Oberlin College in Ohio, with a focus on bioanalytical chemistry. As an undergraduate she work under Dr. Rebecca Whelan of Oberlin College, discovering DNA aptamers that could selectively bind HE4, an ovarian cancer biomarker, to facilitate the creation of new ovarian cancer assays. She also worked under Dr. Mark Parkin of Kings College London on an on-line microchamber that was used to metabolize performance-enhancing drugs for immediate analysis by liquid chromatography-mass spectrometry.
Her research in the Bush lab focuses on using native mass spectrometry to characterize the assembly, stoichiometry, and stability of proteins and protein complexes. These experiments reveal biologically relevant data that was previously inaccessible using more traditional structural biology techniques. She also works with the emerging structures for lossless ion manipulation (SLIM), which she will use to expand the portfolio and information content of gas-phase experiments for rapid characterization of protein structures and protein complexes.
- Eaton, R.M.; Shallcross, J.A.; Mael, L.E.; Mears, K.S.; Minkoff, L.; Scoville, D.J.; Whelan, R.J. Selection of DNA Aptamers for Ovarian Cancer Biomarker HE4 using CE-SELEX and High-throughput Sequencing. Anal. Bioanal. Chem. 2015, 407, 6965-6973.
- Eaton, R.M.; Allen, S.J.; Bush, M.F. “Analysis of Native-like Ions Using Structures for Lossless Ion Manipulation.” American Society for Mass Spctrometry Asilomar Conference. Pacific Grove, CA, 10/19/2015.
- Eaton, R.M.; Whelan, R.J. “Selection of HE4 Aptamers Using CE-SELEX”, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Chicago, IL, 3/3/2014.
Awards and Honors:
- NSF Graduate Research Fellow, Current
- PNNL Graduate Fellow, Spring 2015
- ARCS Foundation Fellow
- Inductee, Sigma Xi, Spring 2013