{"id":12,"date":"2017-01-06T22:10:24","date_gmt":"2017-01-06T22:10:24","guid":{"rendered":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/?page_id=12"},"modified":"2021-07-20T15:08:09","modified_gmt":"2021-07-20T22:08:09","slug":"maves-lab","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/","title":{"rendered":"Maves Lab"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"alignleft\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"200\" src=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2019\/08\/20180906_226-website.jpg\" alt=\"\" class=\"wp-image-1733\"\/><\/figure><\/div>\n\n\n\n<p>The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new understanding of, and treatments for, muscular dystrophy and heart disorders. We primarily use the zebrafish as an animal model because of its advantages for genetic manipulations, in vivo imaging, and drug screening. By using the power of genetics and embryo development, we can gain insights into the origins of heart and muscle disease.<\/p>\n\n\n\n<hr class=\"wp-block-separator\"\/>\n\n\n\n<p>We currently have three main projects.<\/p>\n\n\n\n<p>1) We are using a zebrafish model of Duchenne muscular dystrophy (the <em>dmd<\/em> mutant strain) to investigate the developmental biology and epigenetics of DMD as well as to identify new drug therapies for DMD. We also work closely with Dr. David Mack\u2019s lab (<a href=\"https:\/\/iscrm.uw.edu\/faculty\/david-l-mack\/\">https:\/\/iscrm.uw.edu\/faculty\/david-l-mack\/<\/a>) to take advantage of human iPSC and rat models of DMD.<\/p>\n\n\n\n<p>2) We are investigating the mechanisms of skeletal muscle fiber-type differentiation. This work will eventually help us understand why certain types of muscle fibers are more susceptible to muscular dystrophy.<\/p>\n\n\n\n<p>3) We are using CRISPR genome screening and precision editing in zebrafish to engineer mutations in genes that have been implicated in human congenital heart defects. Recently our screening has identified several new genes required for heart development. Our goal is to gain insight into the complex genetics of congenital heart defects.<\/p>\n\n\n\n<p>Contact Lisa Maves directly at <a href=\"mailto:lmaves@u.washington.edu\">lmaves (at) u.washington.edu<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Maves lab investigates skeletal muscle and heart development, with the goal of making discoveries that lead to new understanding of, and treatments for, muscular dystrophy and heart disorders. We primarily use the zebrafish as an animal model because of its advantages for genetic manipulations, in vivo imaging, and drug screening. By using the power &#8230; <\/p>\n<p class=\"read-more-container\"><a title=\"Maves Lab\" class=\"read-more button\" href=\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#more-12\" aria-label=\"More on Maves Lab\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":190,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":{"0":"post-12","1":"page","2":"type-page","3":"status-publish","4":"has-post-thumbnail","6":"no-featured-image-padding"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v18.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Maves Lab - Center for Developmental Biology and Regenerative Medicine<\/title>\n<meta name=\"description\" content=\"Maves Lab - Center for Developmental Biology and Regenerative Medicine\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Maves Lab - Center for Developmental Biology and Regenerative Medicine\" \/>\n<meta property=\"og:description\" content=\"Maves Lab - Center for Developmental Biology and Regenerative Medicine\" \/>\n<meta property=\"og:url\" content=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"Center for Developmental Biology and Regenerative Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2021-07-20T22:08:09+00:00\" \/>\n<meta property=\"og:image\" content=\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"631\" \/>\n\t<meta property=\"og:image:height\" content=\"845\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website\",\"url\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/\",\"name\":\"Center for Developmental Biology and Regenerative Medicine\",\"description\":\"CDBRM\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg\",\"contentUrl\":\"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg\",\"width\":631,\"height\":845},{\"@type\":\"WebPage\",\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#webpage\",\"url\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/\",\"name\":\"Maves Lab - Center for Developmental Biology and Regenerative Medicine\",\"isPartOf\":{\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website\"},\"primaryImageOfPage\":{\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#primaryimage\"},\"datePublished\":\"2017-01-06T22:10:24+00:00\",\"dateModified\":\"2021-07-20T22:08:09+00:00\",\"description\":\"Maves Lab - Center for Developmental Biology and Regenerative Medicine\",\"breadcrumb\":{\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"CDBRM Home\",\"item\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Research Labs\",\"item\":\"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Maves Lab\"}]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","description":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/","og_locale":"en_US","og_type":"article","og_title":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","og_description":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","og_url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/","og_site_name":"Center for Developmental Biology and Regenerative Medicine","article_modified_time":"2021-07-20T22:08:09+00:00","og_image":[{"width":631,"height":845,"url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg","type":"image\/jpeg"}],"twitter_card":"summary","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebSite","@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website","url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/","name":"Center for Developmental Biology and Regenerative Medicine","description":"CDBRM","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"ImageObject","@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#primaryimage","inLanguage":"en-US","url":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg","contentUrl":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-content\/uploads\/2017\/01\/purplegreenmaves.jpg","width":631,"height":845},{"@type":"WebPage","@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#webpage","url":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/","name":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","isPartOf":{"@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/#website"},"primaryImageOfPage":{"@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#primaryimage"},"datePublished":"2017-01-06T22:10:24+00:00","dateModified":"2021-07-20T22:08:09+00:00","description":"Maves Lab - Center for Developmental Biology and Regenerative Medicine","breadcrumb":{"@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/"]}]},{"@type":"BreadcrumbList","@id":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/maves-lab\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"CDBRM Home","item":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/"},{"@type":"ListItem","position":2,"name":"Research Labs","item":"http:\/\/depts.washington.edu\/cdbrm\/wordpress\/research-labs-center-for-developmental-biology-and-regenerative-medicine\/"},{"@type":"ListItem","position":3,"name":"Maves Lab"}]}]}},"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/12"}],"collection":[{"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/comments?post=12"}],"version-history":[{"count":29,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/12\/revisions"}],"predecessor-version":[{"id":2333,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/12\/revisions\/2333"}],"up":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/pages\/8"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/media\/190"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/cdbrm\/wordpress\/wp-json\/wp\/v2\/media?parent=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}