Current and Past Awardee Research

2015 Awardees

2014 Awardees

2013 Awardees

Investigator

Title of Study

Award Type and Year

Joseph Babigumia, PhD, MS, MBChB

Economic and Behavioral Psychological Determinants of the Demand for Medical Male Circumcision for HIV Prevention

NIA 2015

Paul Drain, MD, MPH

Point-of-care viral load testing to enable task shifting for chronic HIV care

NIA 2015

Alison Drake, MPH, PhD

Oral home-based HIV testing for repeat maternal HIV testing in Kenya
 

NIA 2015

Paul Edlefsen, PhD

Statistical Assessment of HIV-1 Integration Bias: A Comparative Study

NIA 2015

Jennifer Balkus, PhD, MPH

Development and Validation of an HIV Risk Assessment Tool for South African Women

NIA 2014

James Cowan, MD, MPH, MBA

Strengthening the HIV/MDR-TB Diagnostic and Care Cascade in Central Mozambique

NIA 2014

Terri DiMaio, PhD

Kaposi’s sarcoma herpesevirus infection of lymphatic endothelial progenitor cells

NIA 2014

Dara Lehman, PhD, MHS

Characterizing transmission of low-frequency resistance variants

NIA 2014

Marta Bull, PhD

Immune responses to HSV-2 recurrence replenish HIV tissue reservoirs during ART

NIA 2013B

Brandon Guthrie, PhD

Improving Linkage to HIV Care Following Provider Initiated Testing and Counseling

NIA 2013B

Erick Matsen, PhD

Machine learning to expand our knowledge of APOBEC3 specificity and improve classification of HIV mutations

NIA 2013B

Jennifer Slyker, MSc, PhD

Immunologic correlates of EBV containment in HIV infected infants

NIA 2013B

Rachel Winer, PhD, MPH

Methylation Markers for Anal Cancer Screening in HIV-Positive Men

NIA 2013B

Susan Cassels, PhD, MPH

HIV and residential mobility among men who have sex with men over the life course

NIA 2013A

Emily Ho, MD, PhD Central nervous system events in HIV-infected patients with syphilis NIA 2013A

Romel Mackelprang, PhD

Mechanisms underlying the impact of Toll-like receptor variants on HIV-1 outcomes

NIA 2013A

Lishomwa Ndhlovu, MD, PhD

Charting mechanisms of NK-cell dysfunction in the failure to control HIV-1

NIA 2013A

Richard Fox, PhD

Sorted bead sequencing of HIV to provide loss-less sequencing and quantitation

EOG 2012

Helen Horton, PhD

HIV, Aging, and MDSC

EOG 2012

Lucia Vojtech, PhD

Effect of exosomes and exosomal miRNA in semen on mucosal immunity to HIV

EOG 2012

Ruanne Barnabas, Dphil, MSc, MBChB

Co-infection interventions to delay HIV progression: Effectiveness estimates

NIA 2012

Sarah Benki, PhD, MS

HIV and child neurodevelopment in Kenya

NIA 2012

Maria Lemos, PhD, MPH

B-cell responses at the foreskin

NIA 2012

Alison Roxby, MD, MSc

Progesterone-based contraception and immune activation in postpartum Kenyan women

NIA 2012

Kenneth Sherr, PhD, MPH

Systems analysis and improvement to optimize pMTCT in central Mozambique

NIA 2012

Connie Celum, MD, MPH

Expanding UW malaria epidemiology and immunology research in Kampala

EOG 2011

Keith Jerome, MD, PhD

Dendritic cell-based delivery for genetic therapy of latent HIV infection

EOG 2011

Joanne Stekler, MD, MPH

Development of a SmartPhone app for research with men who have sex with men in Seattle

EOG 2011

Jodie Goodridge, PhD

Cooperation of HLA-F and MHC class I in cross-presentation of HIV antigen 

NIA 2010

Susan Graham, MD, MPH 

The Role of Angiopoietins 1 and 2 in HIV-1 Disease Progression

NIA 2010

Christoph Grundner, PhD  

Phosphosignaling Correlates of Mycobacterium tuberculosis Latency and Reactivation

NIA 2010

Antje Heit, MD, Dr. Med.

Phenotypic, functional and kinetic properties of NK cells induced by HIV vaccines

NIA 2010

Heather Jaspan, MD, PhD 

Assessing exclusive breast versus mixed feeding-associated immune activation and microbial with regard to potential HIV infection

NIA 2010

Cynthia Pearson, PhD 

 

Social networks in HIV and substance use prevention among Native American women

NIA 2010

Kym Ahrens, MD, MPH

Using Attachment Theory to Understand the HIV/STI Risk of Youth in Foster Care

NIA 2009B

Bhavna Chohan, PhD 

Development of ARV Resistance in Early Treated HIV-1 Infected Infants

NIA 2009B

Shokrollah Elahi, PhD

Regulatory T cells Differentially Suppress HIV-Specific CD8+ T Cells depending on their Restricting HLA-alleles

NIA 2009B

Deepa Rao, PhD

Toward Availability of an Effective Mental Health Intervention for People with HIV in India

NIA 2009B

Jennifer Slyker, PhD

Valacyclovir for the prevention of vertical cytomegalovirus transmission

EOG 2009

Jared Baeten, MD, Phd

HIV-1 subtype diversity: implications for HIV-1 transmission and prevention 

NIA 2009A

Catherine Blish, MD, PhD

Defining deficits in immunity during HIV-1/Mycobacterium tuberculosis co-infection 

NIA 2009A

Joshua Herbeck, PhD 

 Validation and analysis of candidate AIDS restriction genes

NIA 2009A

Robert Smith, PhD

 

Lethal mutagenesis and the error threshold of HIV

NIA 2009A

Rosa Solorio, MD, MPH

Development of an intervention to increase HIV antibody testing in young Hispanic MSM

NIA 2009A

Tong Wang, PhD

Monocyte-derived primary infectious HIV-1 and brain transmission

NIA 2009A

Jared Baeten, MD, PhD

Improving adherence in an HIV Prevention Trial: A Pilot Intervention

EOG 2008

Robert Choi, MD, MPH

The role of mucosal IgA in protection against HIV-1 Acquisition

EOG 2008

Megan Moreno, MD, MPH

Is the online display of sexual material by 18-year-olds on MySpace associated with sexual activity or sexual intention?

EOG 2008

Soren Gantt, MD, PhD 

 Primary Human Herpes virus 8 Infection in Ugandan Children

NIA 2007

Morgane Rolland, PhD

How Deleterious Mutations Become Fixed in HIV-1 Genomes without Impeding Evolutionary Adaptation

NIA 2007

Yegor Voronin, PhD

Population Genetics of HIV Drug Resistance 

NIA 2007

Susan Cassels, PhD

HIV Serosorting among men who have sex with men: modeling HIV transmission dynamics

EOG 2007

Charles Emlet, MD

Older adults in the HIV/AIDS epidemic: a pilot study of aging and disability resource centers in Washington state

EOG 2007

Susan Graham, MD, MPH

The Role of HSV-2 infection in HIV-1 prevalence and acquisition among men who have sex with men in Kenya

EOG 2007

Kelly Cue Davis, PhD

Heterosexual Risk: Effects of Men’s Alcohol Use and Intimate Partner Violence 

NIA 2006

Masahiro Yamashita, PhD

Molecular Mechanism on HIV Infection in Non-Dividing Cells

NIA 2006

Qigui Yu, MD, PhD

Development of Molecular Adjuvants for Therapeutic HIV-1 Vaccines 

NIA 2006

Natalie Zheng, PhD

Discern Mechanisms of HIV-2 Gag Specific Responses in Control of HIV-1 Infection 

NIA 2006

Kawango Agot Widow Inheritance and HIV: Where does the inheritor fit in the risk puzzle?  EOG 2006
Morgane Rolland, PhD Fitness-informed design of a HIV-C gag immunogen EOG 2006

Publications and Presentations From New Investigator Awards

Jared Baeten

  • Baeten JM. Adherence in HIV Type 1 Prevention Trials. J Infect Dis. 2010 May 1; 201(9):1285-97. PMID: 20235837. 
  • Lingappa J, Thomas K, Hughes J, Baeten J, Fife K, de Bruyn G, Farquhar C, Kapiga S, Makhema J, Celum C for the Partners in Prevention HSV/HIV Transmission Study Team.  Infected partner’s plasma HIV-1 RNA level and the HIV-1 set point of their heterosexual seroconverting partners.  18th Conference on Retroviruses and Opportunistic Infections.  Boston, USA, 27 February – 2 March, 2011.  Abstract 134.

Susan Cassels

  • Cassels S, Menza TW, Goodreau SM, Golden MR. HIV serosorting as a harm reduction strategy: evidence from Seattle, Washington. AIDS. 2009 Nov 27;23(18):2497-506. PubMed PMID: 19834319. PMCID: PMC2886722.
  • Cassels S, Menza TW, Goodreau SM, Golden MR. Available evidence does not support serosorting as an HIV risk reduction strategy: author’s reply. AIDS. 2010 Mar 27:24(6):936-8. PubMed PMID: 20234197. PMCID Pending.
  • Cassels, S, Menza TW, and Goodreau SM. HIV serosorting among men who have sex with men: population-level impacts of partner selection and sexual behavior.  Oral presentation, Annual Meetings of the Population Association of America, Detroit, MI: April 30–May 2, 2009.
  • Cassels S, Menza TW, and Goodreau SM. HIV serosorting among men who have sex with men: population-level impacts of partner selection and sexual behavior. Poster presentation at Epidemics Conference, Asilomar, CA: December 1-3, 2008.  

Kelly Cue Davis

  • Greene, P.L. & Davis, K.C.. Latent profiles of risk among a community sample of men: Implications for sexual aggression. Journal of Interpersonal Violence. 2010 Aug 18. PMID: 20587458. PMCID Pending.
  • Davis, K.C., Schraufnagel, T.J., George, W.H., & Norris, J. (2008). The use of alcohol and condoms during sexual assault. American Journal of Men’s Health, 2008 Sep;2(3):281-90. Epub 2008 Jul 3. PubMed PMID: 19477791.
  • Logan-Greene, P. L. & Davis, K. C. (in press). Latent profiles of risk among a community sample of men: Implications for sexual aggression. Journal of Interpersonal Violence.
  • Davis, K.C., Schraufnagel, T.J., George, W.H., & Norris, J. (2008). The use of alcohol and condoms during sexual assault. American Journal of Men’s Health, 2008 Sep;2(3):281-90. Epub 2008 Jul 3. PubMed PMID: 19477791.

Charles Emlet

  • Emlet CA, Gerkin A, Orel N. The graying of HIV/AIDS: preparedness and needs of the aging network in a changing epidemic. J Gerontol Soc Work. 2009 Nov;52(8):803-14. PubMed PMID: 19830608. PMCID Pending.
  • Hudson A, Emlet CA, Older Adults in the HIV/AIDS Epidemic: A Pilot Survey of Area Agencies on Aging in Washington State, UW Undergraduate Research Symposium, May 16, 2008, in http://www.washington.edu/research/urp/symp/downloads/08_Symposium_Proc… , page 115.
  • Emlet CA, Gerkin A. Serving Older Adults in the HIV/AIDS Epidemic: A Pilot Survey of Area Agencies on Aging in Washington State  61st Annual Scientific Meeting of the Gerontological Society of America, National Harbor, Maryland, November 2008, Abstract #404-1.

Susan Graham

  • Okuku HS, Sanders EJ, Nyiro J, Ngetsa C, Ohuma E, McClelland RS, Price MA, Graham SM. Factors associated with herpes simplex virus type 2 incidence in a cohort of HIV-1-seronegative Kenyan men and women reporting high-risk sexual behavior. Oral presentation. Conference on Retroviruses and Opportunistic Infection in Boston, MA February 27 – March 2, 2011.
  • Sanders EJ, Okuku HS, Mwangome M, Fegan G, Peshu N, van der Elst EM, Price MA, McClelland RS, Smith AD, Graham SM. Risk factors for HIV-1 infection among men who have sex with men (MSM) in Coastal Kenya. Poster presentation. Conference on Retroviruses and Opportunistic Infection in Boston, MA February 27 – March 2, 2011.

 Joshua Herbeck

  • Herbeck, JT, et al. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. Journal of Infectious Diseases 2010, Feb 15; 201(4): 618-626. NIHMSID#: 174410, PMID#: 20064070. PMCID#: PMC2928718.
  • Bol, S.M., Moerland, P.D., Limou, S., van Remmerden, Y., Coulonges, C., van Manen, D., Herbeck, J.T., Fellay, J., Sieberer, M., Sietzema, J.G., van’t Slot, R., Martinson, J., Zagury, J-F., Schuitemaker, H. and A.B. van’t Wout. Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages. 2011.  PLoS ONE, 6: e17190. PMCID#: PMC3045405.
  • Le Clerc, S., Coulonges, C., Delaneau, O., van Manen, D., Herbeck, J.T., Limou, S., An, P., Martinson, J., Spadoni, J-L., Therwath, A., Taing, L., Labib, T., Mellak, S., Montes, M., Delfraissy, J-F., Schachter, F., Winkler, C., Froguel, P., Mullins, J.I., Schuitemaker, H. and J-F Zagury. Screening low frequency SNPs from genome wide association study reveals a new risk allele for progression to AIDS. 2011. J AIDS, 56: 279-284. PMID: 21107268. PMCID# Pending.
  • Boutwell, C., Rolland, M., Herbeck, J.T., Mullins, J.I. and T.A. Allen. Viral evolution and escape during acute HIV-1 infection. Journal of Infectious Diseases, 2010. 202 Suppl 2: S309-14. PMID: 20846038. PMCID#: PMC2945609.
  • Limou, S., Coulonges, C., Herbeck, J.T., van Manen, D., An, P., Le Clerc, S., Delaneau, O., Diop, G., Taing, L., van’t Wout, A. B., Gottlieb, G.S., Therwath, A., Rouzioux, C., Delfraissy, J-F., Lelievre, D., Levy, Y., Hercberg, S., Dina, C., Estaquier, J., Schachter, F., Gut, I., Froguel, P., Mullins, J.I., Schuitemaker, H., Winkler, C. and J-F Zagury. Multiple-cohort genetic association study reveals CXCR6 as a new chemokine receptor risk involved in AIDS long-term non-progression. 2010. Journal of Infectious Diseases, 202: 908-15. PMID: 20704485. PMCID# Pending.
  • Herbeck, J.T., Gottlieb, G., Wong, K.G, and J.I. Mullins. Fidelity of SNP array genotyping using Epstein-Barr Virus-transformed B-lymphocyte cell lines:  Implications for genome-side association studies. 2009. PLoS ONE, 4: e6915. PMCID: PMC2731852.

Megan Moreno

  • Moreno MA, Brockman LN, Wasserheit J, Christakis DC.  Adolescents' online sexual reference display is associated with sexual intention.  Presented at MSPR October 2009.
  • Moreno MA, Brockman LN, Wasserheit J, Christakis DC.  Adolescents' online sexual reference display is associated with sexual intention.  Presented at European Society for Sexual Medicine, Lyon, France, November 2009. Poster 12-010.
  • Moreno MA, Brockman LN, Wasserheit J, Christakis DC.  Adolescents' online sexual reference display is associated with sexual intention.  Presented at Pediatric Academic Society meeting May 2010. 

Morgane Rolland

  • Rolland M, Carlson JM, Manocheewa S, Swain JV, Lanxon-Cookson E, Deng W, Rousseau CM, Raugi DN, Learn GH, Maust BS, Coovadia H, Ndung'u T, Goulder PJ, Walker BD, Brander C, Heckerman DE, Mullins JI. Amino-acid co-variation in HIV-1 Gag subtype C: HLA-mediated selection pressure and compensatory dynamics. PLoS One. 2010 Sep 1;5(9). pii: e12463. PMID: 20824187. PMCID#: PMC2931691,
  • Rolland M, Carlson JM, Deng W, Rousseau CM, Goulder PJ, Walker BD, Brander C, Heckerman D, Mullins JI. Amino acid co-variation and compensatory dynamics in HIV-1 Gag subtype C. 16th Conference on Retroviruses and Opportunistic Infections, Montreal, CA, Feb 8-11th, 2009, Abstract #444.
  • Liu Y, McNevin J, Rolland M, Zhao H, Deng W, Maenza J, Stevens CE, Collier AC, McElrath MJ, Mullins JI. Conserved HIV-1 epitopes continuously elicit subdominant cytotoxic T-lymphocyte responses. J Infect Dis. 2009 Dec 15;200(12):1825-33. PubMed PMID: 19909083; PMCID: PMC2783836.

Rosa Solorio

  • Solorio R. Development of an HIV Antibody Testing Intervention for Latino Men. National Hispanic Science Network on Drug Abuse: Tenth Annual International Conference, September 30- October 2, 2010, New Orleans, LA, USA. Poster Presentation.

Robert Smith 

  • Smith RA, G.S. Gottlieb and A.D. Miller.  Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors.  Retrovirology 2010 Aug 31; 7:70. PMCID#: PMC2939604.
  • Smith RA. Contamination of clinical specimens with MLV-encoding nucleic acids: Implications for XMRV and other candidate human retroviruses.  Retrovirology. 2010 Dec 21; 7:112. PMCID#: PMC3022688.
  • Smith RA. Random-scanning Mutagenesis.  In: Methods in Molecular Biology #634: In Vitro Mutagenesis Protocols, Third Edition. Chapter 27, pgs. 387-397.  Jeff Braman (ed.), Humana Press, New York.  PMID: 20676998. PMCID# Pending.
  • Smith RA, G.S Gottlieb and A.D. Miller.  Susceptibility of XMRV to Antiretroviral Inhibitors.  Poster Presentation, Retrovirus Meeting, Cold Spring Harbor NY, May 28, 2010.

Yegor Voronin

  • Voronin Y. Genetic drift of HIV populations in culture. 15th International HIV Dynamics and Evolution Conference, April 27-30, 2008, Santa Fe, New Mexico, USA 
  • Voronin Y, Holte S, Overbaugh J, Emerman M. Genetic Drift of HIV Populations in Culture. PLoS Genetics. 2009 Mar;5(3):e1000431. Epub 2009 Mar 20.PMID: 19300501. PMCID: PMC2652835.

Tong Wang 

  • He, F., Zeng, Y.*, Wu, X., Ji, Y., He, X., Andrus, T., Zhu, T., and Wang, T*. Endogenous HIV-1 Vpr-mediated apoptosis and proteome alteration of human T-cell leukemia virus-1 transformed C8166 cells, Apoptosis 14, 1212-26 (2009). PMID: 19655254 (* Corresponding authors) PMCID Pending.
  • Wang, T., Xu, Y., Zhu, H., Ivanov, S., Pan, C., Dann, G., Dolores, J., Andrus, T., and Zhu., T*. Biological characterization of HIV-1 isolated from purified human monocytes, CROI (2010), #D-180, meeting abstract.

Masahiro Yamashita

  • Yamashita M, Emerman M. Cellular restriction targeting viral capsids perturbs human immunodeficiency virus type 1 infection of nondividing cells. J Virol. 2009 Oct;83(19):9835-43. Epub 2009 Jul 22. PubMed PMID: 19625401; PubMed Central PMCID: PMC2748051.
  • Yamashita M, Perez O, Hope TJ, Emerman M. Evidence for direct involvement of the capsid protein in HIV infection of nondividing cells. PLoS Pathog. 2007 Oct 26;3(10):1502-10. PMID 17967060. PMCID: PMC2042020.
  • Yamashita M and Emerman M. Loss of the cell-cycle independence of HIV-1 by TRIM proteins. The 15th West Coast Retrovirus Meeting, Palm Springs, CA, October 16-18, 2008.
  • Yamashita M and Emerman M, Evidence for direct Involvement of the capsid protein and host cell proteins in HIV infection of nondividing cells. 8th Annual Symposium on Antiviral Drug Resistance, Richmond VA, Nov. 11-14, 2007.
  • Yamashita M and Emerman M. Identification of HIV Capsid Mutations that Affect Infectivity in Non-dividing Cells. The Thirteenth West Coast Retrovirus Meeting, Palm Springs, CA, October 5-7, 2006. 

Qigui Yu

  • Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, Shiramizu B, Halperin JA, Qin X.  A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS. J Immunol. 2010 Jan 1;184(1):359-68. Epub 2009 Dec 2. PubMed PMID: 19955519.
  • Munsaka SM, Agsalda M, Troelstrup D, Hu N, Yu Q, Shiramizu B. Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus. Immunol Immunogenet Insights. 2009;1:15-20. PubMed PMID: 19997535; PubMed Central PMCID: PMC2789571.
  • Hu N, Yu R, Shikuma C, Shiramizu B, Ostrwoski MA, Yu Q. Role of cell signaling in poxvirus-mediated foreign gene expression in mammalian cells. Vaccine. 2009 May 14;27(22):2994-3006. Epub 2009 Mar 10. PubMed PMID: 19428911.
  • Liu J*, Yu Q*, Stone GW, Yue FY, Ngai N, Jones RB, Kornbluth RS, Ostrowski MA. CD40L expressed from the canarypox vector, ALVAC, can boost immunogenicity of HIV-1 canarypox vaccine in mice and enhance the in vitro expansion of viral specific CD8+ T cell memory responses from HIV-1-infected and HIV-1-uninfected individuals. Vaccine. 2008 Jul 29;26(32):4062-72.  *first co-authors. PMID 18562053. 
  • Yu, Q., Hicks, BW. Chapter 22, in Methods of Molecular Biology, Viral Application of Green Fluorescent Protein (Humana Press Inc.). 2009, vol. 515.  
  • Shikuma C, Shiramizu B, Yewdell JW, Moss B, Yu Q. A Potentially Negative Impact of Antiretroviral Therapy on Efficacy of Live Poxvirus-based Vaccines. Experimental Biology 2008, April 5-9, San Diego, California. 
  • Yu Q, Hu N, Shikuma C, Shiramizu B, Yewdell JW, Moss B. Role of PI3K signaling pathway in HIV-1 antigen expression by live poxvirus-based HIV-1 vaccines. 26th Annual Meeting of the American Society for Virology, July 12-16, 2008, Cornell University, Ithaca, New York.
  • Yu Q, Hu. N., Shiramizu B, Koo R, Yewdell J, Shikuma C. Antigen expression and processing by recombinant vaccinia virus-infected human dendritic cells requires PI3K, p38 MAPK, and JUK signaling. 26th Annual Meeting of the American Society for Virology, July 14-18, 2007, Corvallis, Oregon.

Natalie Zheng 

  • Zheng NN, McElrath MJ, Papa Sow S, Mesher A, Hawes SE, Stern J,
 Gottlieb GS, De Rosa SC & Kiviat NB.  Association between peripheral
 gammadelta T-cell profile and disease progression in individuals infected with
 HIV-1 or HIV-2 in West Africa.  2011 JAIDS (in press).
  • Crawford DC, Zheng N, Speelmon EC, Stanaway I, Rieder MJ, Nickerson DA, McElrath MJ, Lingappa J. An excess of rare genetic variation in ABCE1 among Yorubans and African-American individuals with HIV-1. Genes Immun. 2009 Dec;10(8):715-21. Epub 2009 Aug 6. PubMed PMID: 19657357; PubMed Central PMCID: PMC2829431.
  • Zheng NN, McElrath JM, Sow P, Mesher A, Hawes S, Stern J, Gottlieb G, De Rosa S & Kiviat NB.  Higher frequencies of gd T cells are associated with undetectable plasma viral loads in HIV-2 infections. Poster Abstract for 15th Conference on Retroviruses and Opportunistic Infections, Boston, MA, Feb 3-6, 2008. Abstract 314.
  • Zheng NN, Sow P, Mesher A, Stern J, Gottlieb G, Hawes S, McElrath MJ & Kiviat NB.  Role of CD4+CD25+hi regulatory T cells in HIV-1 and HIV-2 infections. Poster Abstract for 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, Feb 8-11, 2009. Abstract 319.