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The HIV Specimen Repository is a collection of frozen plasma, PBMC, serum and PaxGene specimens donated by HIV infected patients cared for at the University of Washington HIV clinics (the Madison and Roosevelt Virology Clinics).
The Clinical Research and Retrovirology Cores have merged! The combined Clinical and Retrovirology Research Core helps investigators perform clinical studies by supporting enrollment of HIV-infected patients, facilitating use of frozen specimens, providing laboratory testing for HIV markers, and assisting with overall study logistics and training.
Both basic and clinical scientists at CFAR benefit from the services and consultations of the Core. Our dedicated research nurses at Harborview and University of Washington HIV clinics speed the recruitment, screening, and enrollment of appropriate patients into new translational studies.
With our HIV Specimen Repository—which contains frozen plasma, serum, PBMC and PaxGene specimens linked to extensive clinical data—we offer immediate access to large numbers of well characterized samples for translational studies. The Core’s HIV Specimen Bank also provides researchers with a ready infrastructure for collecting and storing specimens for new clinical and pathogenesis studies. Most patient records reflect serial specimen donations (3X/year) with full data linked from electronic medical records, including virologic, immunologic, infectious, genetic, and demographic factors.
In addition, advanced virology services and support offered by the Core allow CFAR investigators to monitor key indicators of HIV pathogenesis, transmission risk, disease progression, drug susceptibility, and post-treatment regression. Core faculty apply the most appropriate methods for preparing specimens and select the best current technology and protocols for quantifying proteins or nucleic acids. Core faculty can assist with design, methods, quality assurance, and data interpretation in clinical studies of AIDS/HIV. They can partner with CFAR researchers to develop novel laboratory methods for determining viral loads in various compartments and correlating these HIV markers with clinical outcomes.
To help researchers incorporate or adapt the latest laboratory tools into their study planning and design, the Core provides training, education, and workshops for CFAR investigators. In their own research, the Core faculty also evaluate new technologies and compare alternative laboratory methods using good clinical laboratory practice methods.
The Clinical and Retrovirology Research Core has helped accelerate the funding and progress of many important studies—especially smaller studies or those championed by new investigators who have limited budgets or require mentoring with clinical, laboratory, or regulatory aspects of their research.
Examples of Core efforts include:
Increasing Enrollment of HIV+ Patients into Multiple Research Studies.
Providing Access to Thousands of Data-Rich Frozen Specimens
Relieving Research Partner of Need to Re-Invent Specimen Collection Service
Robert Harrington, MD, Core Director
Bob Coombs, MD, PhD, Co-Director
Jairam Lingappa, MD, PhD, Associate Director
Lisa Frenkel, MD, Associate Director
Joan Dragavon, MLS, Research Scientist
dragavon at uw.edu
Michalina Montaño, MS, Program Manager
micham at uw.edu
Lindsay Legg, LPN, Research Nurse Coordinator
lmlegg at uw.edu
Core Committee: Connie Celum, MD, MPH; Robert Harrington, MD; Ann Collier, MD; Robert Coombs, MD, PhD; Joan Dragavon, MLM; Mari Kitahata, MD, MPH; Jairam Lingappa, MD, PhD; Stephen Van Rompaey, PhD; Jeanne Marrazzo, MD, MPH; Matthew Golden, MD, MPH.