CFAR Localizing Global Research Pilot Award

Closing Date

Required Pre-Award Deadlines

  • Monday, October 17, 2016: Materials submitted for CAB Consultation
  • Thursday, November 10, 2016: Behavioral or Biomedical Intervention Eligibility Check
  • Sunday, December 4, 2016: Applications Due

Localizing Global Research Pilot Awards

Purpose

  • To translate knowledge, collaborations, and expertise from research conducted in low and middle income countries into projects that aim to benefit disadvantaged communities in Washington State.
  • To support trainees and junior faculty currently involved in international collaborative HIV research in the establishment of bridging projects that add value and build new collaborations to benefit the local community
  • Projects should generate data that will inform the development of new grant proposals.
  • To provide preliminary data from populations in the US that complement data from parallel studies at international sites. 

The Localizing Global Research (Glocal) pilot awards are for development and implementation of innovative and collaborative HIV-related research projects by junior faculty. Pilot awards provide an opportunity to initiate new research or to leverage new directions for research within ongoing projects that will provide important preliminary data to seed future larger proposals by junior investigators. Studies with potential to obtain pilot data for development of future grant proposals are given priority.

The purpose of the Glocal pilot awards is to translate knowledge, collaborations, and expertise from research conducted in low and middle income countries into projects that aim to benefit disadvantaged communities in Washington State.  Trainees and junior faculty currently involved in international collaborative HIV research are encouraged to submit proposals that would result in the establishment of bridging projects that add value and build new collaborations to benefit the local community.  A project is defined as Glocal if it incorporates lessons learned by the Principal Investigator and collaborators in the global context and applies them appropriately to the local context.

Below is a list of project topics developed based on the interests of the CFAR Community Action Board.  Investigators interested in working on these topics should contact Julia Dettinger (cfarintl@uw.edu) for information on linking with relevant community partners. 

  • Addressing disparities along the continuum of care (diagnosis, linkage to care, etc.) for African-born, African American, US-born Latin@, or foreign-born Latin@ communities.
  • Projects addressing stigma among young black MSM.
  • HIV Prevention strategies/interventions among Women of Color.
  • Support strategies for seropositive women, particularly relating to stigma and/or navigating relationships.

Past successful applications include:

  • “Safer Conception among Seattle Area HIV-1 Serodiscordant Couples” which seeks to understand which strategies would be feasible to reduce peri-conception HIV-1 risk.
  • “Promise of a Peer Support Intervention to Promote Care Engagement and ART Adherence among Young Black MSM in Washington State” which will determine the acceptability of a peer support approach based on the Shikamana model used in Kenya.

Eligibility

To be eligible, a PI must be a junior investigator at a UW/Fred Hutch CFAR affiliated institution: Fred Hutchinson Cancer Research Center, Center for Infectious Disease Research, Seattle Children’s, University of Hawaii and affiliated international institutions (listed here).

  1. Junior investigators are defined as:
  • Current UW junior faculty (including acting positions through Assistant Professor) who have not had an R01 grant in HIV/AIDS. Senior applicants may apply if the proposal reflects a new research direction.
  • Scientists completing fellowships
  • Senior post-doctoral fellows
  • Junior faculty being recruited to the UW faculty or affiliated institutions
  • Investigators with comparable appointments at UW-affiliated institutions
  1. Each international PI must partner with a faculty co-investigator from the University of Washington or UW-affiliated institutions.
  2. Additional guidance on eligibility for Glocal proposals:
    1. Proposals should generate new data from disadvantaged populations in Washington State that are complementary to data from parent studies at international sites.  The pilot proposal must add value to a current or recent (past 24 months) international research project led by the PI or a CFAR faculty co-investigator.
    2. Proposals should include one or more international co-investigators from the current or recently completed international research.  Successful proposals will clearly demonstrate how the proposal leverages international expertise in the local implementation, such that both the local and international partners benefit from the extension of research to the US.
  3. If the PI is a US-based applicant, an international co-investigator must be included in key personnel.

Contact cfarintl@uw.edu if you have questions about eligibility.

Types of projects

HIV-related research is defined broadly and includes basic science, clinical, epidemiological, behavioral, and health services research.

We can only accept applications in the NIH’s HIV/AIDS research high or medium priority areas.

Per NIH, we cannot fund research with investigational drugs or clinical trials. If you are considering a study involving approved drugs and/or standard-of-care, please contact Julia Dettinger (cfarintl@uw.edu) to determine whether your proposed project would be eligible for funding through CFAR.

Funding Available

Direct costs: $15,000 US for over one year. Previously funded projects will not be considered. Funding cannot be applied to alterations or renovations of any facilities or IRB/ERC fees. If the proposal requires a sub-contract, subcontractor F&A costs must be budgeted as a direct cost. Please note that the CFAR has negotiated indirect cost waivers with several local institutions, including Fred Hutch, CIDR (formerly Seattle BioMed) and Seattle Children’s. For international institutions, the allowable F&A rate to be budgeted as a direct cost is 8%. For domestic organizations without an established F&A rate, the default F&A rate is 10%.  If the proposal funds work through UW Kenya, the 13% UW Kenya recharge fee must be budgeted as a direct cost. 

Pre-Submission Requirements

CFAR Community Action Board Consultation: Scheduling a consultation with the CFAR Community Action Board (CAB) is required by October 17, 2016.  CAB Consultations can be conducted electronically or in person at a special CAB Steering Committee meeting on October 24, 2016 (or both).  To request a CAB consultation, complete the “Localizing Global Research CAB consultation form” attached below and send it to Julia Dettinger at cfarintl@uw.edu by Monday October 17, 2016 to ensure space on the CAB steering committee agenda. Early communication with the CAB is strongly advised.

Intervention Eligibility Check: If your proposed study design involves testing a biomedical or behavioral intervention (including approved drugs and/or standard of care), please contact the International Core Program Manager at cfarintl@uw.edu by Tuesday, November 10, 2016 to determine whether the proposed project would be eligible for funding at cfarintl@uw.edu.  Please include a brief description of 1) the study group(s), 2) the planned intervention and how it will be assigned, and 3) your proposed outcomes.

Letters of Support: Applications must include letters of support from all key personnel including faculty co-investigator(s) and any community-based organizations you may partner with.

CFAR Membership: All applicants are required to be UW/Fred Hutch CFAR Members. Information about membership can be found at http://depts.washington.edu/cfar/get-involved/cfar-membership or by contacting Linh Nguyen (ltn128@uw.edu).

Pre-Submission Recommendation:

Biostatistical Consultation: All applicants are strongly advised to discuss their proposal with one of CFAR’s biostatisticians prior to/during the preparation of their application, as the proposals will be evaluated for statistical content. If you are a local investigator, please contact Sarah Holte (sholte@fredhutch.org) to schedule your in-person biostatistical review. You will be required to submit a draft of your methods 48 hours before your consultation. If you are an international investigator, please send a copy of your draft methods to Julia Dettinger (cfarintl@uw.edu) and she will arrange your written consultation with a CFAR biostatistician.

Use of CFAR Resources: 

We encourage all applicants to use or contact CFAR Cores or link to CFAR Scientific Working Groups (see below). Information about other CFAR cores and services can be found at http://depts.washington.edu/cfar/find-a-service.  These consultations are best done early in the preparation process but should be completed no later than November 10th, 2016.

Administrative Consultation: Applicants from all (including UW) institutions are strongly encouraged to consult with the Program Manager about their budgets to clarify budgetary issues. Please send a draft copy of your budget and justification to Julia Dettinger at cfarintl@uw.edu.

Curative Therapies for HIV Study Consultation: Applicants proposing a study in HIV cure have the opportunity to have an expert from the Curative Therapies for HIV Scientific Working Group consult with them regarding their study. In order to receive this consultation, applicants should contact Tom Andrus at tandrus@fredhutch.org.

Substance Abuse and HIV/STI Study Consultation: Applicants proposing a study in the field of substance abuse and HIV/STI have the opportunity to have an expert from the Substance Abuse and HIV/STI Scientific Working Group consult with them regarding their study. In order to receive this consultation, applicants should contact Dennis Donovan at ddonovan@uw.edu.

International Study Consultation: International applicants have the option of receiving an International Core Consultation to help evaluate their study design. In order to receive this consultation, applicants must email a draft of their application to Julia Dettinger at cfarintl@uw.edu.

Health Economics Consultation: Applicants using Health Economic Methods have the options of receiving a Health Economics Impact Study Team Consultation to help their study design. In order to receive this consultation, applicants must email a draft of their application to Julia Dettinger at cfarintl@uw.edu.

Sociobehavioral Study Consultation: Applicants performing behavioral or qualitative research have the opportunity to have an expert from the Sociobehavioral and Prevention Research Core consult with them regarding their study design. In order to receive this consultation, applicants must email a draft of their application to Susan Mello at sprc@uw.edu.

Clinical Research Study Consultation: Those proposing clinical, translational or basic research projects that require access to local research subjects, clinical specimens/procedures or viral assays such as droplet PCR, 2LTR, single copy RNA tests and proviral DNA measurements may contact the Clinical and Retrovirology Research Core to discuss their proposal. Applicants should contact the Core Manager Michalina Montano (micham@uw.edu) with a short description of the study and requested resources for assistance.

Immunological Study Consultation: Applicants proposing an immunology or other appropriate basic research study have the opportunity to have an expert from the Immunology Core consult with them regarding their experimental design. In order to receive this consultation, applicants should contact Stephen De Rosa at sderosa@fredhutch.org.

Implementation Science Study Consultation: Applicants proposing a study in the field of implementation science have the opportunity to have an expert from the Implementation Science Working Group consult with them regarding their study. In order to receive this consultation, applicants should contact Kenny Sherr at ksherr@uw.edu.

Molecular Profiling and Computational Biology Consultation: Applicants proposing a study involving sequence based assays have the opportunity to have an expert from the Molecular Profiling and Computational Biology core consult with them regarding their study. To receive this consultation, applicants should send a brief email to cfarcompbio@fredhutch.org including a few sentences describing, briefly, the nature of your questions and your contact information.

Review Criteria

Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge be advanced?

Approach: Are the conceptual framework, design, methods, and analyses adequate and appropriate to the aims of the project?

Innovation: Does the project employ novel concepts, approaches or method? Are the aims original and innovative?

Investigators (including relationship to UW/Fred Hutch CFAR): Is the investigator appropriately trained and well suited to carry out this work? CFAR prioritizes junior investigators and the investigators must meet the eligibility criteria described above.

Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Is there evidence of institutional support? Though projects in any country are eligible, CFAR International target countries include Peru, Kenya, Mozambique, Senegal, Uganda and China.

Feasibility: Is the study feasible given the duration of one year and a budget of $15,000?

Potential for new collaborations: Although we prioritize CFAR links and target particular countries, we are also encouraging relationships with new investigators who are not currently linked to CFAR. We welcome new investigators who bring expertise in new, relevant disciplines to forge interdisciplinary collaborations. 

Potential for new research projects and career development: The projects should aid in the development of the investigator by providing important data for a larger NIH (or other) funded study such as an R01.

Added value of Localizing Global Research Linkage:  To what extent will the project help to highlight the value that your international research provides locally as well as globally?

Pre-Award Requirements

Per NIH policy, UW/Fred Hutch CFAR may not release pilot research funds until awardees complete the NIH administrative clearance process. Clearance will require final IRB approval from all participating institutions and documentation of human subjects training from all investigators. This process often takes several months, so please consider it in your timeline. More information on NIH requirements for international studies can be found at:

http://www.niaid.nih.gov/LabsAndResources/resources/cfar/Pages/guidelin…

**Projects that are unable to complete the NIH clearance process within one year of award date are at risk of losing funding**

Post-Award Requirements

CFAR support must be acknowledged in all publications derived from CFAR funding. Suggested wording is available here.

A progress report is required annually and upon completion of the project. This should include information about publications, collaborations, and future grants related to your CFAR project.

Application Instructions

After fulfilling all pre-submission requirements, submit your application by December 4, 2016to cfarintl@uw.edu using the following application form. The application, any letters of support, biosketches and any other supporting documentation must be combined into a single PDF. Application sections can be expanded or shortened, however proposal narratives (the application form sections 1 – 12, excluding the budget and biosketches) should be no longer than five pages. A letter of support is required from any collaborating community based organizations.

Application Form