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Seattle Children's Research Institute
Joined the Uganda Program in 2006, began working on human herpesvirus 8/Kaposi sarcoma with Corey Casper and others
This talk will highlight the work ongoing in Uganda and Seattle to understand the factors that affect control of HHV-8 infection and progression to Kaposi sarcoma (KS). Rather than a traditional malignancy, KS can be best understood as a proliferation of HHV-8-infected cells with concomitant hypervascularity and inflammation that is driven by HHV-8 lytic gene products. Increased HHV-8 replication and risk of KS are clearly associated with immunodeficiency, though the specific responses that are important are unclear. Other risk factors that may be important include age at HHV-8 infection, and malaria and other co-infections. The implications of this work for strategies to prevent KS will be discussed.