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Past Pilots<\/h1>\n\n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t

Funding Source<\/th>	Principal Investigator \nDepartment<\/th>	Funding Period<\/th>	Project title<\/th>\n<\/tr>\n<\/thead>\n
P30 CFRTC<\/td>	Beno Freedman PhD<\/a> Nephrology<\/td>	2022-24<\/td>	Modeling CFTR function with human kidney organoids<\/td>\n<\/tr>\n
CFF RDP<\/td>	Eric Morrell, MD<\/a> \nPulmonary<\/td>	2021-24<\/td>	Role of Soluble PD-L1 in Chronic Lung Allograft Dysfunction<\/td>\n<\/tr>\n
CFF RDP<\/td>	Amy Willis, PhD<\/a> \nBiostatistics<\/td>	2021-23<\/td>	Estimating the composition of the cystic fibrosis pulmonary microbiome \n<\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Pavan Bhatraju, MD<\/a> \nPulmonary \n<\/td>	2018-23<\/td>	Identification of Predictive Biomarkers for Antibiotic Associated Nephrotoxicity in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Jim Kublin, MD, MPH<\/a> \nVaccine & ID, Hutch \n<\/td>	2020-23<\/td>	Investigating Mechanisms of Vaccine Response Deficiency in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Sakeneh Zraika, PhD<\/a> \nMetabolism<\/td>	2020-23<\/td>	Impact of Intra-Islet GLP-1 Signaling on \u00df-cell Function in CFRD<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Eric Morrell, MD, MA<\/a> \nPulmonary<\/td>	2019-22<\/td>	Immune Tolerance and Inflammation in Lung Transplant Rejection<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	David Sherman, PhD<\/a> \nMicrobiology<\/td>	2019-21<\/td>	Inferring drug interactions in M. abscessus using chemo-genomics and orthology<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Richard James, PhD<\/a> \nJason Debley, MD<\/a> \nPediatrics<\/td>	2019-20<\/td>	Approach to CFTR Editing in Differentiated Airway Epithelial Cells<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Marion Pepper, PhD <\/a> Immunology<\/td>	2018-21<\/td>	Pseudomonas-specific immune responses in CF patients<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Jisun Paik, PhD<\/a> Comparative Medicine \n Luke Hoffman, MD, PhD<\/a>, Pediatrics<\/td>	2018-20<\/td>	Gastrointestinal dysbiosis as a modifier of CF infant somatic growth: A murine investigation<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Steve Salipante, MD, PhD<\/a>, Lab Medicine<\/td>	2018-20<\/td>	Cell-free Bacterial DNA to Identify Mycobacterial Lung Pathogens in CF<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Andrew Graustein, MD<\/a> \nPulmonary<\/td>	2017-20<\/td>	The NLRP3 Inflammasome in The Cystic Fibrosis Lung<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Thomas Hawn, MD, PhD<\/a> \nAllergy & ID<\/td>	2017-19<\/td>	The Inflammasome in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Jason Debley, MD<\/a> \nDavid Nichols, MD \nPediatrics<\/td>	2017-19<\/td>	Testing association between epithelial chloride transport and measures of clinical improvement<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Matthew Parsek, PhD<\/a> \nMicrobiology<\/td>	2016-20<\/td>	Microbial colonization and adaptation to the CF gut<\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Neal Paragas, PhD<\/a> \nNephrology<\/td>	2016-19<\/td>	Identification of Biomarkers for Cystic Fibrosis Associated Nephrotoxicity<\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Lynn Hajjar, DVM, PhD<\/a> \nComparative Medicine \n<\/td>	2016-18<\/td>	Lung and gastrointestinal homeostasis in a germ-free CF mouse model<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Marika Bogdani, PhD<\/a> \nBenaroya<\/td>	2016-17<\/td>	Hyalouronan and hlyaladherins in the pathogenesis of cystic fibrosis related diabetes<\/td>\n<\/tr>\n
CFF RDP<\/td>	Steve Salipante, MD, PhD<\/a>, Lab Medicine<\/td>	2015-18<\/td>	Mechanisms and fitness of spontaneous aztreonam resistance in Pseudomonas aeruginosa<\/em><\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	William Altemeier, MD<\/a> \nPulmonary<\/td>	2015-18<\/td>	Role of the Microvasculature in Neutrophilic Lung Disease of Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Steven Kahn, MB, ChB<\/a> \nMetabolism<\/td>	2014-19<\/td>	Mechanisms of Late Hypoglycemia in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Ian de Boer, MD<\/a> \nNephrology<\/td>	2014-18<\/td>	Vitamin D metabolism in cystic fibrosis<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Rafael Hernandez, MD, PhD<\/a>, Pediatrics<\/td>	2014-17<\/td>	Efflux Pumps in Nontuberculosis Mycobacteria<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Anne Manicone, MD<\/a> \nPulmonary<\/td>	2014-17<\/td>	Functional Consequences and Signaling Pathways of Macrophage Repolarization<\/a><\/td>\n<\/tr>\n
CFF RDP<\/td>	Donald Chi, DDS, PhD<\/a> \nDentistry<\/td>	2013-17<\/td>	Testing a Multifactorial Caries Model for Pediatric Patients with Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Elhanan Borenstein, PhD<\/a>, Genome Sciences<\/td>	2013-14<\/td>	Advanced computational methods for identifying compositional shifts in the CF gut microbiome<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Lucas Hoffman, MD, PhD<\/a> \nPediatrics<\/td>	2013-14<\/td>	Acute Effects of Kalydeco in People with CF and the G551D Mutation<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Rebecca Hull, PhD<\/a> \nMetabolism \nSrinath Sanda, MD<\/a> \nPediatrics, UCSF<\/td>	2012-17<\/td>	Role of Islet Amyloid and IL-1\u03b2 Signaling in \u03b2-cell Loss in Cystic Fibrosis-Related Diabetes<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Ian Sweet, PhD<\/a> \nMetabolism<\/td>	2012-15<\/td>	Biochemical Mechanisms Mediating Impaired Insulin Secretion in Mouse Models of Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Lev Becker, PhD<\/a> \nPediatrics, U Chicago<\/td>	2012-15<\/td>	Investigating the effects of CFTR Correction on Myeloid Cell Function<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Lev Becker, PhD<\/a> \nPulmonary<\/td>	2010-13<\/td>	Macrophage and Dendritic Cell Pathways in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n
P30 CFRTC<\/td>	Lucas Hoffman, MD, PhD<\/a> \nPediatrics<\/td>	2010-13<\/td>	Describing the gut microbiome of early childhood and infant Cystic Fibrosis patients<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n  <\/p>\n   \n[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Past Pilots \n\n\n\n\t\n\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t\n\t Funding Source<\/th> Principal Investigator \nDepartment<\/th> Funding Period<\/th> Project title<\/th>\n<\/tr>\n<\/thead>\n P30 CFRTC<\/td> Beno Freedman PhD<\/a> Nephrology<\/td> 2022-24<\/td> Modeling CFTR function with human kidney organoids<\/td>\n<\/tr>\n CFF RDP<\/td> Eric Morrell, MD<\/a> \nPulmonary<\/td> 2021-24<\/td> Role of Soluble PD-L1 in Chronic Lung Allograft Dysfunction<\/td>\n<\/tr>\n CFF RDP<\/td> Amy Willis, PhD<\/a> \nBiostatistics<\/td> 2021-23<\/td> Estimating the composition of the cystic fibrosis pulmonary microbiome \n<\/td>\n<\/tr>\n P30 CFRTC<\/td> Pavan Bhatraju, MD<\/a> \nPulmonary \n<\/td> 2018-23<\/td> Identification of Predictive Biomarkers for Antibiotic Associated Nephrotoxicity in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Jim Kublin, MD, MPH<\/a> \nVaccine & ID, Hutch \n<\/td> 2020-23<\/td> Investigating Mechanisms of Vaccine Response Deficiency in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Sakeneh Zraika, PhD<\/a> \nMetabolism<\/td> 2020-23<\/td> Impact of Intra-Islet GLP-1 Signaling on \u00df-cell Function in CFRD<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Eric Morrell, MD, MA<\/a> \nPulmonary<\/td> 2019-22<\/td> Immune Tolerance and Inflammation in Lung Transplant Rejection<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> David Sherman, PhD<\/a> \nMicrobiology<\/td> 2019-21<\/td> Inferring drug interactions in M. abscessus using chemo-genomics and orthology<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Richard James, PhD<\/a> \nJason Debley, MD<\/a> \nPediatrics<\/td> 2019-20<\/td> Approach to CFTR Editing in Differentiated Airway Epithelial Cells<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Marion Pepper, PhD <\/a> Immunology<\/td> 2018-21<\/td> Pseudomonas-specific immune responses in CF patients<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Jisun Paik, PhD<\/a> Comparative Medicine \n Luke Hoffman, MD, PhD<\/a>, Pediatrics<\/td> 2018-20<\/td> Gastrointestinal dysbiosis as a modifier of CF infant somatic growth: A murine investigation<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Steve Salipante, MD, PhD<\/a>, Lab Medicine<\/td> 2018-20<\/td> Cell-free Bacterial DNA to Identify Mycobacterial Lung Pathogens in CF<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Andrew Graustein, MD<\/a> \nPulmonary<\/td> 2017-20<\/td> The NLRP3 Inflammasome in The Cystic Fibrosis Lung<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Thomas Hawn, MD, PhD<\/a> \nAllergy & ID<\/td> 2017-19<\/td> The Inflammasome in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Jason Debley, MD<\/a> \nDavid Nichols, MD \nPediatrics<\/td> 2017-19<\/td> Testing association between epithelial chloride transport and measures of clinical improvement<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Matthew Parsek, PhD<\/a> \nMicrobiology<\/td> 2016-20<\/td> Microbial colonization and adaptation to the CF gut<\/td>\n<\/tr>\n P30 CFRTC<\/td> Neal Paragas, PhD<\/a> \nNephrology<\/td> 2016-19<\/td> Identification of Biomarkers for Cystic Fibrosis Associated Nephrotoxicity<\/td>\n<\/tr>\n P30 CFRTC<\/td> Lynn Hajjar, DVM, PhD<\/a> \nComparative Medicine \n<\/td> 2016-18<\/td> Lung and gastrointestinal homeostasis in a germ-free CF mouse model<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Marika Bogdani, PhD<\/a> \nBenaroya<\/td> 2016-17<\/td> Hyalouronan and hlyaladherins in the pathogenesis of cystic fibrosis related diabetes<\/td>\n<\/tr>\n CFF RDP<\/td> Steve Salipante, MD, PhD<\/a>, Lab Medicine<\/td> 2015-18<\/td> Mechanisms and fitness of spontaneous aztreonam resistance in Pseudomonas aeruginosa<\/em><\/a><\/td>\n<\/tr>\n CFF RDP<\/td> William Altemeier, MD<\/a> \nPulmonary<\/td> 2015-18<\/td> Role of the Microvasculature in Neutrophilic Lung Disease of Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Steven Kahn, MB, ChB<\/a> \nMetabolism<\/td> 2014-19<\/td> Mechanisms of Late Hypoglycemia in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Ian de Boer, MD<\/a> \nNephrology<\/td> 2014-18<\/td> Vitamin D metabolism in cystic fibrosis<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Rafael Hernandez, MD, PhD<\/a>, Pediatrics<\/td> 2014-17<\/td> Efflux Pumps in Nontuberculosis Mycobacteria<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Anne Manicone, MD<\/a> \nPulmonary<\/td> 2014-17<\/td> Functional Consequences and Signaling Pathways of Macrophage Repolarization<\/a><\/td>\n<\/tr>\n CFF RDP<\/td> Donald Chi, DDS, PhD<\/a> \nDentistry<\/td> 2013-17<\/td> Testing a Multifactorial Caries Model for Pediatric Patients with Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Elhanan Borenstein, PhD<\/a>, Genome Sciences<\/td> 2013-14<\/td> Advanced computational methods for identifying compositional shifts in the CF gut microbiome<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Lucas Hoffman, MD, PhD<\/a> \nPediatrics<\/td> 2013-14<\/td> Acute Effects of Kalydeco in People with CF and the G551D Mutation<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Rebecca Hull, PhD<\/a> \nMetabolism \nSrinath Sanda, MD<\/a> \nPediatrics, UCSF<\/td> 2012-17<\/td> Role of Islet Amyloid and IL-1\u03b2 Signaling in \u03b2-cell Loss in Cystic Fibrosis-Related Diabetes<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Ian Sweet, PhD<\/a> \nMetabolism<\/td> 2012-15<\/td> Biochemical Mechanisms Mediating Impaired Insulin Secretion in Mouse Models of Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Lev Becker, PhD<\/a> \nPediatrics, U Chicago<\/td> 2012-15<\/td> Investigating the effects of CFTR Correction on Myeloid Cell Function<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Lev Becker, PhD<\/a> \nPulmonary<\/td> 2010-13<\/td> Macrophage and Dendritic Cell Pathways in Cystic Fibrosis<\/a><\/td>\n<\/tr>\n P30 CFRTC<\/td> Lucas Hoffman, MD, PhD<\/a> \nPediatrics<\/td> 2010-13<\/td> Describing the gut microbiome of early childhood and infant Cystic Fibrosis patients<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n   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