[et_pb_section fullwidth=”on” specialty=”off”][et_pb_fullwidth_slider admin_label=”Fullwidth Slider” show_arrows=”on” show_pagination=”on” auto=”off” parallax=”off” parallax_method=”off” module_id=”interior”][et_pb_slide background_image=”https:\/\/depts.washington.edu\/cfrtc\/wp-content\/uploads\/2014\/12\/microscope.jpg” background_color=”#ffffff” alignment=”center” background_layout=”dark” \/][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section][et_pb_row][et_pb_column type=”1_4″][et_pb_sidebar admin_label=”Fellowships Sidebar” orientation=”left” area=”et_pb_widget_area_11″ background_layout=”light” \/][\/et_pb_column][et_pb_column type=”3_4″][et_pb_text admin_label=”Past Fellow Secor text” background_layout=”light” text_orientation=”left”]<\/p>\n
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Fellow: Patrick Secor, PhD Mentor: \u00a0Pradeep Singh, MD Pseudomonas aeruginosa<\/em> is a major pathogen in Cystic Fibrosis (CF) and the capacity of P. aeruginosa<\/em> to produce biofilms is key to its virulence. Although the production of filamentous bacteriophage by P. aeruginosa<\/em> biofilms is well known, the functional consequence for their presence is not. The goal of the research proposed here is to understand how filamentous phage act as structural components of the biofilm matrix and thus contribute to pathogenesis in the CF lung.<\/p>\n The central hypothesis of this proposal is that phage produced by P. aeruginosa<\/em> in the CF lung contributes to the structural integrity and overall organization of the biofilm matrix by organizing liquid crystal-like structures out of available polymeric materials. These organized polymeric structures likely impact important biofilm phenotypes such as adhesion and antibiotic tolerance. I will pursue these studies in three Specific Aims:<\/p>\n Insight into how phage contribute to P. aeruginosa<\/em> biofilm formation may lead to novel therapeutic strategies to specifically target and hinder the ability of bacteria to establish communities within CF lungs. Such strategies may enhance the antibiotic susceptibility of P. aeruginosa<\/em>, a concept supported by my preliminary data. Furthermore, support from a CFF-RDP Fellowship would greatly aid in development of this project for future, career development funding, such as a K99\/R00 application.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Fellow: Patrick Secor, PhD Mentor: \u00a0Pradeep Singh, MD P.I.: Ian de boer, MD<\/a>
\n<\/a>Pulmonary and Critical Care<\/p>\n
\n<\/a>Professor,\u00a0Microbiology and Pulmonary and Critical Care<\/p>\n\n
\nPulmonary and Critical Care<\/p>\n
\nProfessor
\nMicrobiology and Pulmonary and Critical Care<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"
Associate Professor of Medicine
Nephrology<\/p>