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CFF RDP Pilot <\/p>\n

Investigation of the diagnostic potential of Pseudomonas aeruginosa<\/em> protein levels in blood and urine<\/p>\n<\/h2>\n

PI: \u00a0Jim Bruce, PhD<\/a><\/strong>
\nProfessor, Medicine, Genome Sciences<\/p>\n

Funding Period: 2024 – 2026<\/p>\n

Abstract: Highly effective CFTR modulators like elexacaftor\/tezacaftor\/ivacaftor (ETI) are transformational treatments that improve CFTR activity, lung function and general health. ETI also reduces CF pathogen density in sputum, but most people with Cystic Fibrosis (PwCF) who have lung infections prior to starting ETI remain chronically infected with Pseudomonas aeruginosa (Pa). Moreover, recent work suggests that potent Pa pro-inflammatory effects remain undiminished by ETI and Pa-infected patients will continue to suffer lung-damaging inflammation, even after CFTR function is restored. On the other hand, detecting and monitoring lung infections in PwCF has become increasingly challenging in the post-modulator era due to markedly reduced sputum production. Infection detection is particularly challenging in children and early in infection when sputum-based detection would otherwise trigger key interventions like Pa eradication, anti-inflammatory and suppressive antibiotic treatments. Moreover, bronchoscopy is the major alternative to sputum sampling for accurate diagnosis, but risks and costs prohibit routine use. Thus, there is a major unmet need for new non-invasive approaches for infection detection in CF. This project will utilize mass spectrometry and advanced proteomics methods to investigate PwCF blood and urine levels of Pa proteins previously identified in CF sputum and blood samples as well as discovery of new protein targets for infection diagnostic potential.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

CFF RDP Pilot Investigation of the diagnostic potential of Pseudomonas aeruginosa protein levels in blood and urine PI: \u00a0Jim Bruce, PhD Professor, Medicine, Genome Sciences Funding Period: 2024 – 2026 Abstract: Highly effective CFTR modulators like elexacaftor\/tezacaftor\/ivacaftor (ETI) are transformational treatments that improve CFTR activity, lung function and general health. ETI also reduces CF pathogen […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

P.I.: Steven Kahn, MB, ChB<\/a>
Professor of Medicine
Metabolism, Endocrinology and Nutrition<\/p>

Kristina Utzschneider, MD<\/a>
Associate Professor of Medicine
Metabolism, Endocrinology and Nutrition<\/p>

With the increased life expectancy of patients with cystic fibrosis (CF), other co-morbidities have become apparent in these patients. One of these is abnormal glucose metabolism, where CF-related diabetes (CFRD) is common. More recently, another abnormality of glucose metabolism has been recognized; namely late hypoglycemia following oral glucose loading. In this study, we propose to test the hypothesis that the post-glucose load hypoglycemia observed in patients with CF results from a deficient counterregulatory hormone response and\/or an insulin response that is exaggerated and delayed. This increased insulin response could be the result of an exaggerated incretin hormone response or altered gastric emptying. To address this hypothesis, we will perform a 3-hour oral glucose tolerance test during which we will measure counterregulatory, islet and incretin hormone responses and determine the rate of gastric emptying using acetaminophen. To determine whether patients with CF and late hypoglycemia also have episodes of hypoglycemia during daily living that includes mixed meals, we will use a continuous glucose monitoring system (CGMS) to examine 24-hour glucose profiles for 3 days. All these measures will be compared between patients with CF who develop late hypoglycemia, CF patients who do not develop hypoglycemia, and age and body mass index-matched healthy controls. The findings from this study will provide important new information regarding the mechanism(s) responsible for the late hypoglycemia observed in patients with CF and the data could be used as the basis for future grant applications. The ultimate goal is to gain insight into the condition of late hypoglycemia in order to better manage patients with CF.<\/p>","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[2],"tags":[],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/3348"}],"collection":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/comments?post=3348"}],"version-history":[{"count":6,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/3348\/revisions"}],"predecessor-version":[{"id":3370,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/3348\/revisions\/3370"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/media?parent=3348"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/categories?post=3348"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/tags?post=3348"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}