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Role of Islet Amyloid and Il-1\u03b2 Signaling in \u03b2-cell Loss in Cystic Fibrosis-Related Diabetes<\/p>\n<\/h2>\n
P.I.: Rebecca Hull, PhD<\/a><\/strong> Co-PI: Srinath Sanda, MD<\/a><\/strong> Project Period: 2012 – 2016<\/p>\n Abstract: This proposal seeks to determine the role of IL\u03b2 in the pathogenesis of cystic fibrosis related diabetes (CFRD). CFRD is a unique form of diabetes and new treatments are needed to improve the morbidity and mortality of cystic fibrosis patients. Therefore, the goals of this grant proposal are directly relevant to the mission of the National Institute of Diabetes, Digestive, and Kidney Diseases. The grant proposal consists of 2 broad aims. First, we will compare the degree of amyloid deposition between autopsy pancreas sections from CFRD patients, CF patients without diabetes and age-matched controls. Subjects with type 2 diabetes, and appropriately-matched subjects without type 2 diabetes will serve as positive and negative controls for the measurements of interest. We anticipate that CFRD patients will show extensive deposition of islet amyloid, together with decreased \u03b2-cell area, reduced insulin expression, and increased \u03b2-cell apoptosis. Second we will analyze the same samples for evidence that the IL-1\u03b2 pathway is active. In particular we will stain for IL-1\u03b2, IL-1Ra, NF-\u03baB, MyD88, and CCL2. Aim 2: Do pancreatic sections from patients with CFRD show evidence of IL-1\u03b2 activation? We will also determine whether correlations exist between these markers of the IL-1\u03b2 pathway and measured obtained in Aim1, namely islet amyloid deposition, \u03b2-cell area and measures of \u03b2-cell apoptosis and replication. We anticipate that IL-1\u03b2 activation will be a major feature of the islet in CFRD, suggesting that this pathway may play a role in the pathogenesis of islet dysfunction in this patient population.[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Pilot 5: Role of Islet Amyloid and Il-1\u03b2 Signaling in \u03b2-cell Loss in Cystic Fibrosis-Related Diabetes<\/p>\n P.I.: Rebecca Hull, PhD Srinath Sanda, MD This proposal seeks to determine the role of IL\u03b2 in the pathogenesis of cystic fibrosis related diabetes (CFRD). CFRD is a unique form of diabetes and new treatments are needed to improve the morbidity and mortality of cystic fibrosis patients. Therefore the goals of this grant proposal are directly relevant to the mission of the National Institute of Diabetes, Digestive, and Kidney Diseases.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[12],"tags":[],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/508"}],"collection":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/comments?post=508"}],"version-history":[{"count":16,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/508\/revisions"}],"predecessor-version":[{"id":3320,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/posts\/508\/revisions\/3320"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/media?parent=508"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/categories?post=508"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/cfrtc\/wp-json\/wp\/v2\/tags?post=508"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nResearch Associate Professor of Medicine
\nMetabolism, Endocrinology and Nutrition
\nP30 CFRTC Publications<\/a><\/p>\n
\nAssistant Professor, Pediatrics
\nUniversity of California at San Francisco
\nP30 CFRTC Publications<\/a><\/p>\n
\nResearch Assistant Professor of Medicine
\nMetabolism, Endocrinology and Nutrition<\/p>\n
\nAssociate Professor, Pediatrics
\nUniversity of California at San Francisco<\/p>\n