ResultsSharingFormat: Difference between revisions

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(draft version of data to be shared for meta analysis)
 
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Columns to share for imputed results for meta-analysis
The following variables should be included when sharing imputed results for meta-analysis:


{| class="prettytable"
{| class="prettytable" width="800" border="1"
|-
| variable name
| description
|-
| SNPID
| SNPID
| SNP ID as rs number
| SNP ID as rs number
|-
|-
| chr
| chr
| chromosome number
| chromosome number
|-
|-
| position
| position
| physical position for the reference sequence (NCBI 35, 36)
| physical position for the reference sequence (NCBI 35, 36)
|-
|-
| coded_all
| coded_all
| coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
| coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
|-
|-
| noncoded_all
| noncoded_all
| the alternate allele
| the alternate allele
|-
|-
| strand_genome
| strand_genome
| + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
| + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
|-
|-
| beta
| beta
| beta estimate from genotype-phenotype association, at least 5 decimal places
| beta estimate from genotype-phenotype association, at least 5 decimal places
|-
|-
| SE
| SE
| standard error of beta estimate, to at least 5 decimal places
| standard error of beta estimate, to at least 5 decimal places
|-
|-
| pval
| pval
| p-value of test statistic, here just as a double check
| p-value of test statistic, here just as a double check
|-
|-
| AF_coded_all
| AF_coded_all
| allele frequency for the coded allele
| allele frequency for the coded allele
|-
|-
| HWE_pval
| HWE_pval
| exact test Hardy-Weinberg equilibrium p-value
| exact test Hardy-Weinberg equilibrium p-value
|-
|-
| callrate
| callrate
| genotyping callrate after exclusions
| genotyping callrate after exclusions
|-
|-
| n_total
| n_total
| total sample with phenotype and genotype for SNP
| total sample with phenotype and genotype for SNP
|-
|-
| imputed
| imputed
| 1/0 coding; 1=imputed SNP, 0=not imputed
| 1/0 coding; 1=imputed SNP, 0=not imputed
|-
|-
| used_for_imp
| used_for_imp
| 1/0 coding; 1=used for imputation, 0=not used for imputation
| 1/0 coding; 1=used for imputation, 0=not used for imputation
|-
|-
| oevar_imp
| oevar_imp
| observed divided by expected variance for imputed allele dosage
| observed divided by expected variance for imputed allele dosage
|-
|-
| avpostprob
| avpostprob
| average posterior probability for imputed SNP allele dosage
| average posterior probability for imputed SNP allele dosage* (applies to best-guess genotype imputation)
 
|}
|}


Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; ; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied
''Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; ; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied.''

Revision as of 17:33, 9 May 2008

The following variables should be included when sharing imputed results for meta-analysis:

variable name description
SNPID SNP ID as rs number
chr chromosome number
position physical position for the reference sequence (NCBI 35, 36)
coded_all coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
noncoded_all the alternate allele
strand_genome + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
beta beta estimate from genotype-phenotype association, at least 5 decimal places
SE standard error of beta estimate, to at least 5 decimal places
pval p-value of test statistic, here just as a double check
AF_coded_all allele frequency for the coded allele
HWE_pval exact test Hardy-Weinberg equilibrium p-value
callrate genotyping callrate after exclusions
n_total total sample with phenotype and genotype for SNP
imputed 1/0 coding; 1=imputed SNP, 0=not imputed
used_for_imp 1/0 coding; 1=used for imputation, 0=not used for imputation
oevar_imp observed divided by expected variance for imputed allele dosage
avpostprob average posterior probability for imputed SNP allele dosage* (applies to best-guess genotype imputation)

Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; ; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied.