ResultsSharingFormat: Difference between revisions

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The following variables should be included when sharing imputed results for meta-analysis:
The following variables should be included when sharing imputed results for meta-analysis; large files can be shared among small groups via secure file transfer site (as described in [[ResultsSharing|Results Sharing]])


{| class="prettytable" width="800" border="1"
{| class="prettytable" width="800" border="1"
|-
|-
| variable name
| width="200" | '''''variable name'''''
| description
| '''''description'''''''''''''''
|-
|-
| SNPID
| '''SNPID'''
| SNP ID as rs number
| SNP ID as rs number
|-
|-
| chr
| '''chr'''
| chromosome number
| chromosome number
|-
|-
| position
| '''position'''
| physical position for the reference sequence (NCBI 35, 36)
| physical position for the reference sequence (NCBI 35, 36)
|-
|-
| coded_all
| '''coded_all'''
| coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
| coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
|-
|-
| noncoded_all
| '''noncoded_all'''
| the alternate allele
| the alternate allele
|-
|-
| strand_genome
| '''strand_genome'''
| + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
| + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
|-
|-
| beta
| '''beta'''
| beta estimate from genotype-phenotype association, at least 5 decimal places
| beta estimate from genotype-phenotype association, at least 5 decimal places
|-
|-
| SE
| '''SE'''
| standard error of beta estimate, to at least 5 decimal places
| standard error of beta estimate, to at least 5 decimal places
|-
|-
| pval
| '''pval'''
| p-value of test statistic, here just as a double check
| p-value of test statistic, here just as a double check
|-
|-
| AF_coded_all
| '''AF_coded_all'''
| allele frequency for the coded allele
| allele frequency for the coded allele
|-
|-
| HWE_pval
| '''HWE_pval'''
| exact test Hardy-Weinberg equilibrium p-value
| exact test Hardy-Weinberg equilibrium p-value
|-
|-
| callrate
| '''callrate'''
| genotyping callrate after exclusions
| genotyping callrate after exclusions
|-
|-
| n_total
| '''n_total'''
| total sample with phenotype and genotype for SNP
| total sample with phenotype and genotype for SNP
|-
|-
| imputed
| '''imputed'''
| 1/0 coding; 1=imputed SNP, 0=not imputed
| 1/0 coding; 1=imputed SNP, 0=not imputed
|-
|-
| used_for_imp
| '''used_for_imp'''
| 1/0 coding; 1=used for imputation, 0=not used for imputation
| 1/0 coding; 1=used for imputation, 0=not used for imputation
|-
|-
| oevar_imp
| '''oevar_imp'''
| observed divided by expected variance for imputed allele dosage
| observed divided by expected variance for imputed allele dosage
|-
|-
| avpostprob
| '''avpostprob'''
| average posterior probability for imputed SNP allele dosage* (applies to best-guess genotype imputation)
| average posterior probability for imputed SNP allele dosage* ''(applies to best-guess genotype imputation)''
|}
|}


''Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; ; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied.''
''Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied.''

Revision as of 17:50, 9 May 2008

The following variables should be included when sharing imputed results for meta-analysis; large files can be shared among small groups via secure file transfer site (as described in Results Sharing)

variable name description''''''''''
SNPID SNP ID as rs number
chr chromosome number
position physical position for the reference sequence (NCBI 35, 36)
coded_all coded allele, also called modeled allele (in example of A/G SNP in which AA=0, AG=1 and GG=2, the coded allele is G)
noncoded_all the alternate allele
strand_genome + or -, representing either the positive/forward strand or the negative/reverse strand of the human genome reference sequence; to clarify which strand the coded_all and noncoded_all are on
beta beta estimate from genotype-phenotype association, at least 5 decimal places
SE standard error of beta estimate, to at least 5 decimal places
pval p-value of test statistic, here just as a double check
AF_coded_all allele frequency for the coded allele
HWE_pval exact test Hardy-Weinberg equilibrium p-value
callrate genotyping callrate after exclusions
n_total total sample with phenotype and genotype for SNP
imputed 1/0 coding; 1=imputed SNP, 0=not imputed
used_for_imp 1/0 coding; 1=used for imputation, 0=not used for imputation
oevar_imp observed divided by expected variance for imputed allele dosage
avpostprob average posterior probability for imputed SNP allele dosage* (applies to best-guess genotype imputation)

Please note that a README should be uploaded with a very brief description of the data uploaded, the date, the NCBI human genome reference sequence used (e.g. NCBI 36.2) for strand reference, and the scale of the beta estimates; please also include in the README the SNP HWE p-value, callrate and minor allele frequency filters that have been applied.