Michael H. Gelb

More publications

Duffey, T. A., Sadilek, M., Scott, C. R., Turecek, F., Gelb, M. H. (2010) "Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots:  Application to screening newborns for Mucopolysaccharidosis IV (Maroteaux-Lamy Syndrome)", Anal. Chem., 82:9587-9591. 
Kraus, J.M., Verlinde, C.L.M.J., Karimi, Mandana, Lepesheva, G.I., Gelb, M.H., and Buckner, F.S. (2009) "Rational modification of a candidate cancer drug for use against chagas disease." J. Med Chem. 52:1639-1647.

Bendale, P, Olepu, S, Suryadevara, PK, Bulbule, V, Rivas, K, Nallan, L, Smart, B, Yokoyama, K, Ankala, S, Pendyala, PR, Floyd, D, Lombardo, LJ, Williams, DK, Buckner, FS, Chakrabarti, D, Verlinde, CL, Van Voorhis, WC, Gelb, MH (2007) "Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials," J. Med. Chem., 50, 4585-4605.

Gelb, M.H., Brunsveld, L., Hrycyna, C.A., Michaelis, S., Tamanoi, F. , Van Voorhis, W.C. and Waldmann, H. (2006) "Therapeutic intervention based on protein prenylation and associated modifications," Nature Chem. Biol. 10, 518-528

B.B. Rubin,  G.P. Downey, A. Koh,  N. Degousee,  F. Ghomashchi,  L. Nallan, E. Stefanski, B.P. Smart,  T.F. Lindsay,  V. Cherepanov, E. Vachon,   D. Kelvin,  M. Sadilek,  G.E. Brown,  M.B. Yaffe,  J. Plumb, S. Grinstein, M. Glogauer,  and  M.H. Gelb,  "Cytosolic phospholipase A2 alpha is necessary for platelet activating factor biosynthesis, efficient neutrophil mediated bacterial killing and the innate immune response to pulmonary infection," J. Biol. Chem. 2004 280, 7519.

C.M. Mounier,  F. Ghomashchi,  M.R. Lindsay,   S. James, A.G. Singer, R.G.  Parton,  and M.H. Gelb,  "Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-a," J. Biol. Chem. 2004 279  25024.

N.M. Okeley and M.H. Gelb,  "Membrane Transport, Structure, Function, and Biogenesis: A designed probe for acidic phospholipids reveals the enriched anionic character of the cytosolic face of the mammalian plasma membrane," J. Biol. Chem. 2004, 279 21833.

A.G. Singer,  F. Ghomashchi,  C. Le Calvez,  J. Bollinger, S.  Bezzine , M. Rouault, M. Sadilek,   M. Lazdunski, G. Lambeau  and M.H. Gelb,  "Interfacial Kinetic and Binding Properties of the Complete set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2," J. Biol. Chem. 2002 277 48535.  

S.H. Yang,  M.O. Bergo, J.I. Toth, X. Qiao, Y.  Hu,  S. Sandoval,  M. Meta, P.  Bendale, M.H.  Gelb, S.G. Young,  L.G. Fong,   "Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Bilford progeria syndrome mutation," Proc. Natl. Acad. Sci2005 102 10291.

O. Hucke,  M.H.Gelb,  C.L. Verlinde and  F.S.  Buckner,  "The protein farnesyltransferase inhibitor tipifarnib as a new lead for the development of drugs against Chagas disease," J. Med. Chem. 2005  48 5415.

 L. Nallan, K.D. Bauer, P.  Bendale, K.  Rivas , K. Yokoyama, C.P. Horney, P.R. Pendyala,  D. Floyd,  L.J. Lombardo,   D.K. Williams, A. Hamilton,  S. Sebti,  W.T. Windsor,  P.C. Weber , F.S. Buckner , D. Chakrabarti,  M.H. Gelb,  and W.C. Van Voorhis,  "Protein Farnesyltransferase Inhibitors Exhibit Potent Antimalarial Activity," J. Med. Chem., 2005 48 3704.

 Y. Li,  C.R. Scott, N.A. Chamoles, A.  Ghavami, B.M. Pinto,  F. Turecek and M.H. Gelb, "Direct Multiplex Assay of Lysosomal Enzymes in Dried Blood Spots for Newborn Screening," Clin. Chem. 2004 50 1785.

Y. Lu,  P. Bottari,  F. Turecek,  R. Aebersold,  and M.H. Gelb,   "Absolute Quantification of Specific Proteins in Complex Mixtures Using Visible Isotope-Coded Affinity Tags," Anal. Chem. 2004 76  4104.

Y. Li,  K. Brockman,  F. Turecek,  C.R. Scott and M.H. Gelb, "Tandem Mass Spectrometry for the Direct Assay of Enzymes in Dried Blood Spots: Application to Newborn Screening for Krabbe Disease," Clin. Chem. 2004, 50: 638.

P. Bottari,  R. Aebersold,  F. Turecek  and M.H. Gelb, "Design and Synthesis of Visible Isotope-Coded Affinity Tags for the Absolute Quantification of Specific Proteins in Complex Mixtures," Bioconj. Chem.  2004

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Awards & Activities

Awards

Merck New Faculty Career Development Award (1986-90)

American Cancer Society Postdoctoral Fellowship (1983-85)

Honors

Editorial Advisory Board, "Current Opinion in Chemical Biology" (January 1998)

Editorial Advisory Board, "Current Opinion in Chemical Biology" (January, 1998)

NIH Biochemistry Study Section, Regular Member (October, 1997-)

NIH Biochemistry Study Section, Ad Hoc Member (October, 1997)

Co-Chairman, Gordon Conference in Enzymes, Co-Enzymes, and Metabolic Pathways, Kimball Union Academy, Meriden, NH (July, 1997)

NIH Physical Biochemistry Study Section, Ad Hoc Member (June, 1997)

NIH Biochemistry Study Section, Ad Hoc Member (October, 1996)

NIH Pharmacology Clinical Services Special Emphasis Panel, Ad Hoc Member (May, 1996)

Editorial Board Member, Archives of Biochemistry and Biophysics (July, 1993- )

NIH Pharmacology Study Section Ad Hoc Member (June, 1989)

Chairman of 15 Symposia at various Society Conferences

Editorial Board Member, Journal of Biological Chemistry, (June, 2002-)

Chairman, Keystone Conference on Drugs Against Tropical Protozoan Parasites: Target Selection, Structural Biology, and Rational Medicinal Chemistry, Keystone, CO, (March, 2002)

Co-Chairman, FASEB Summer Conference on Phospholipases, Snowmass, CO, (July, 2000)

Society of Biochemical and Molecular Biology Nominating Committee, (2000)

American Chemical Society, Division of Biological Chemistry, Chair of Nominating Committee (1999)

Co-Chairman, Volcano Conference in Bioorganic Chemistry, Eatonville, WA, (annually since Feb., 1991)

Co-Chairman, Pauling Award Symposium, Seattle, WA, (October, 1990)

Co-Chairman, Symposium in Honor of Robert H. Abeles, Brandeis University

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