Epilepsy – DTI and fMRI in Temporal Lobe Epilepsy

This project will develop new collaborative scientific teams at the University of Washington to work in partnership with the Integrated Brain Imaging Center and apply new imaging methods to degenerative dementia, brain aging, epilepsy, and rehabilitation of paralysis. One cluster of projects will investigate the biological basis of early Alzheimer disease, disorders of attention and concentration in Parkinson disease, and language problems in epilepsy surgery. A second cluster of projects will used EEG and imaging to understand signalling in brain systems and how to extract signals for controlling brain-computer interfaces.

Our group is involved in a subproject of analysis of DTI and fMRI in both adults and children with temporal lobe epilepsy.

Figure right is an example of fractional anisotropy (FA) symmetry analysis using FSL in a 6-month-old subject with infantile spasms secondary to tuberous sclerosis complex. FA maps were coregistered to standard space.  Panels A-C demonstrate skeletonized, symmetrised white matter tracts in green in the coronal, midsagittal, and axial planes, respectively.  Blue represents voxels with greater FA in the right hemisphere compared to the left, and red represents voxels with greater FA in the left hemisphere. Axial T2-weighted image demonstrates numerous areas of hyperintense T2 signal consistent with cortical tubers as well as subependymal nodules (Panel D).

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