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Directory >> Karol Bomsztyk, MD

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Karol Bomsztyk, MD

  • Professor of Medicine and Adjunct Professor of Pharmacology
    University of Washington

Although, historically, inflammation has been thought to be the hallmark of infections, allergy, kidney and rheumatologic diseases, it has now been recognized that inflammation is also a critical component in many other disorders including diabetes, atherosclerosis, and even cancer. Altered expression of inflammatory mediator genes is at the core of disease-related inflammation. Thus, understanding nuclear processes that control expression of inflammatory mediators is critically important for developing diagnostic biomarkers and control of inflammatory responses that contribute to disease.

Detrimental epigenetic processes are emerging as major pathophysiologic culprits of disease including inflammation. These processes involve signaling, transcription and epigenetic factors that regulate gene transcription in the chromatin environment, or the epigenome. To better define epigenetic processes in health and disease, our laboratory has been developing high throughput and sensitivity epigenetic platforms and computational tools that can be applied to study inflammation associated with kidney disease, diabetes, multiple organ dysfunction in sepsis and other disorders. For example, using these strategies we have shown that canonical plasma receptors, kinases and phosphatases are directly recruited to chromatin encompassing disease and organ injury-related genes, potentially identifying these gene-associated epigenetic enzymes and factors as targets for rational therapeutic interventions.

Current research projects available to trainees include epigenetic studies of inflammation as well as multiple organ injury in experimental sepsis, development of high throughput and sensitivity epigenetic methods, development of urine and blood epigenetic biomarkers , development of computational tools to acquire, analyze and visualize epigenetic data.

Dr. Bomsztyk research area interests:

  • Pathogenesis of Bacterial, Fungal, and Parasitic Diseases
  • Epigenetics of Inflammation and Infection
  • epigenetics of HIV infection.

  • Selected Publications

    Losartan reverses permissive epigenetic changes in renal glomeruli of diabetic db/db mice. Reddy MA, Sumanth P, Lanting L, Yuan H, Wang M, Mar D, Alpers CE, Bomsztyk K, Natarajan R. Kidney Int. 2014 Feb;85(2):362-73. PMID: 24088954
    PubMed Abstract


    Synchronous recruitment of epigenetic modifiers to endotoxin synergistically activated Tnf-α gene in acute kidney injury. Bomsztyk K, Flanagin S, Mar D, Mikula M, Johnson A, Zager R, Denisenko O. PLoS One. 2013 Jul 30;8(7):e70322. PMID: 23936185
    PubMed Abstract


    Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Komers R, Mar D, Denisenko O, Xu B, Oyama TT, Bomsztyk K. Lab Invest. 2013 May;93(5):543-52. PMID: 23508046
    PubMed Abstract


    Yu J, Feng Q, Ruan Y, Komers R, Kiviat N, Bomsztyk K. Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays. BMC Mol Biol. 2011; 12: 49.
    PMID: 22098709 PMCID: PMC3247195.
    PubMed Abstract


    Mikula M, Bomsztyk K. Direct recruitment of ERK cascade components to inducible genes is regulated by heterogeneous nuclear ribonucleoprotein (hnRNP) K. J Biol Chem. 2011; 286(11): 9763-75. PMID: 21233203 PMCID: PMC3058954.
    PubMed Abstract


    Nelson JD, LeBoeuf RC, Bomsztyk K. Direct recruitment of insulin receptor and  ERK signaling cascade to insulin-inducible gene loci. Diabetes. 2011; 60(1): 127-37. PMID: 20929976
    PMCID: PMC3012164.
    PubMed Abstract


     

     

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