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Directory >> Ferric C. Fang, MD

Faculty

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Ferric C. Fang, MD

  • Professor of Laboratory Medicine and Microbiology
  • Adjunct Professor of Medicine
  • University of Washington

The Fang laboratory studies a broad range of topics in bacterial pathogenesis, with a particular focus on phagocyte-pathogen interactions. Specific projects include the antimicrobial actions of reactive oxygen and nitrogen species in Salmonella enterica and Staphylococcus aureus pathogenesis, iron metabolism in host-pathogen interactions, control of Salmonella virulence gene expression by alternative sigma factors and other transcriptional regulators, and the pathogenesis of human typhoid. Using a genomic approach, the Fang laboratory discovered "xenogeneic silencing," a mechanism by which bacteria recognize and integrate foreign DNA into pre-existing regulatory networks. Professor Fang also oversees the Clinical Microbiology Laboratory of the 413-bed Harborview Medical Center, where he is working on molecular methods for improved diagnosis of bacterial infections.


Selected Publications


Navarre WW, Porwollik S, Wang Y, McClelland M, Rosen H, Libby SJ, Fang FC. Selective silencing of foreign DNA with low GC content by the H-NS protein in Salmonella. Science. 2006; 313(5784): 236-8.
PubMed Abstract


Richardson AR, Libby SJ, Fang FC. A nitric oxide-inducible lactate dehydrogenase enables Staphylococcus aureus to resist innate immunity. Science. 2008; 319(5870): 1672-6.
PubMed Abstract


Libby SJ, Brehm MA, Greiner DL, Shultz LD, McClelland M, Smith KD, Cookson BT, Karlinsey JE, Kinkel TL, Porwollik S, Canals R, Cummings LA, Fang FC. Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection. Proc Natl Acad Sci U S A. 2010; 107(35): 15589-94.
PubMed Abstract


Frawley ER, Crouch ML, Bingham-Ramos LK, Robbins HF, Wang W, Wright GD, Fang FC. Iron and citrate export by a major facilitator superfamily pump regulates metabolism and stress resistance in Salmonella Typhimurium. Proc Natl Acad Sci U S A. 2013; 110(29): 12054-9.
PubMed Abstract


Kinkel TL, Roux CM, Dunman PM, Fang FC. The Staphylococcus aureus SrrAB two-component system promotes resistance to nitrosative stress and hypoxia. mBio. 2013; 4(6): e00696-13
PubMed Abstract

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