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Directory >> Denise Galloway, PhD

Faculty

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Denise Galloway, PhD

  • Research Professor of Microbiology
  • Associate Division Director, Human Biology, Fred Hutchinson Cancer Research Center

Dr. Galloway's lab is interested in the mechanisms by which human papillomaviruses (HPVs) and human polyomaviruses (HPyV) contribute to cancers. Most of their research has focused on the E6 and E7 oncogenes of the HPVs that have a high risk of progression to cervical cancers, such as HPV 16. The Lab studies the response to DNA damage in both high risk HPVs and the beta HPVs, a group of viruses that commonly infect skin. In addition to mechanistic studies, the Galloway lab has had long-standing collaborations with epidemiologists and clinicians to understand the natural history of genital HPV infections, and the risk factors that cause only a small subset of women infected with high risk HPVs to progress to cancer. They have developed new serologic assays to detect antibodies to many HPVs and HPyVs and are currently studying the memory response to HPV infection and vaccination.

Selected Publications

Scherer, E., M., Smith, R.A., Simonich, C.A., Niyonzima, N., Galloway, D.A.  Characteristics of memory B cells elicited by a highly efficacious HPV vaccine in subjects with no pre-existing immunity. PLoS Pathogens.  Oct 16;10(10):e1004461. doi: 10.1371/journal.ppat.1004461. eCollection 2014 Oct. 2014. 
PubMed Abstract

Wallace, N.A., Robinson, K.L., Galloway, D.A. Beta-HPV 5 and 8 E6 disrupt homology dependent double strand break repair by attenuating BRCA1 and BRCA2 expression and foci formation.  PLoS Pathog. 2015 Mar;11(3):e1004687. PubMed PMID:25803638; PubMed Central PMCID: PMC4372404. 2015.
PubMed Abstract

Carter, J.J.*, Daugherty, M.D.*, Qi, X., Bheda-Malge, A., Wipf, G.C., Robinson, K., Roman, A., Malik, H.S., Galloway, D.A. Identification of an overprinting gene in Merkel Cell polyomavirus provides evolutionary insight into the birth of viral genes.   Proc Natl Acad Sci USA. 30; 110 (31):12744-9. 2013.
PubMed Abstract

*Xu, M., * Katzenellenbogen, R.A., Grandori, C., Galloway, D.A. An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.  Virology, 446:17-24. 2013.
PubMed Abstract

*Paulson, K.G., *Carter, J.J., Johnson, L.G., Cahill, K., Wipf, G.C., Iyer, J.,   Schrama, D., Becker, J., Madeleine, M., Nghiem*, P., Galloway*, D.A.   Antibodies to Merkel cell polyomavirus oncoproteins reflect Merkel cell carcinoma tumor burden.  Cancer Research, 70 (21):8388-8397. 2010. 
PubMed Abstract

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