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Directory >> Denise Galloway, PhD

Faculty

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Denise Galloway, PhD

  • Research Professor of Microbiology
  • Member & Program Head, Fred Hutchinson Cancer Research Center

Dr. Galloway's lab is interested in the mechanisms by which human papillomaviruses (HPVs) contribute to epithelial cancers. Most of their research has focused on the E6 and E7 oncogenes of the HPVs that have a high risk of progression to cervical cancers, such as HPV 16. In addition to mechanistic studies, the Galloway lab has had long-standing collaborations with epidemiologists and clinicians to understand the natural history of genital HPV infections, and the risk factors that cause only a small subset of women infected with high risk HPVs to progress to cancer. More recently, they have begun to study a different group of HPVs, known as the genus beta HPVs. These beta HPVs commonly infect skin, and may play a role in squamous cell skin cancers (SCSC). They have developed new serologic assays to detect antibodies to many HPVs and to human polyomaviruses.


Selected Publications


Egelkrout EM, Galloway DA. The biology of genital human papillomaviruses. In: Holmes KK, Sparling PF, Stamm WE, Piot P, Wasserheit JN, Corey L, Cohen M, eds. Sexually Transmitted Diseases. 4th ed. China: McGraw-Hill; 2008: 463-489.


Underbrink MP, Howie HL, Bedard KM, Koop JI, Galloway DA. E6 proteins from multiple human betapapillomavirus types degrade Bak and protect keratinocytes from apoptosis after UVB irradiation. J Virol. 2008; 82(21): 10408-17.
PubMed Abstract


Howie HL, Katzenellenbogen RA, Galloway DA. Papillomavirus E6 proteins. Virol. 2009; 384(2): 324-34.
• PubMed Abstract


Galloway, DA. Human papillomaviruses: a growing field. Genes Dev. 2009; 23(2): 138-42.
PubMed Abstract


Katzenellenbogen RA, Vliet-Gregg P, Xu M, Galloway DA. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol. 2009; 83(13): 6446-56.
PubMed Abstract

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