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Directory >> William Reed Henderson Jr., MD

Faculty

Contact Information

William Reed Henderson Jr., MD

  • Professor and Head, Allergy Section
    Director, Allergy and Immunology Fellowship Training Program
    Director, Center for Allergy and Inflammation
    Division of Allergy and Infectious Diseases, Department of Medicine
  • University of Washington

Research in Dr. Henderson's laboratory focuses on:

  • secreted phospholipase A2 and 5-lipoxygenase products of arachidonic acid metabolism in airway inflammation.
  • IgE-mediated airway remodeling in asthma chemogenomics to identify new molecular targets in pulmonary fibrosis.
  • role of progenitor cells in lung repair in mouse models of pulmonary fibrosis and asthma.

From the 5-lipoxygenase products of arachidonic acid metabolism studies,the Henderson lab is trying to determine the role of specific sPLA2s vs. cPLA2 and cysteinyl leukotrienes in the mediation of IgE-induced airway inflammation and remodeling in a mouse asthma model. Functional genomic studies (i.e., microarray and proteomic analyses) are being performed to determine the molecular mechanisms that mediate allergen-induced airway inflammation and remodeling. Research to identify new molecular targets in pulmonary fibrosis involve studies to determine the effect of novel antifibrotic agents on profibrotic gene expression in the airways in a mouse model of PF. These studies represent a focused effort using chemogenomics to identify, develop, and validate small molecule inhibitors of profibrotic gene expression (microarray and proteomic studies) as novel therapies in PF patients. Stem cells (embryonic and adult bone marrow-derived mouse and human cells) will be isolated and manipulated ex vivo in culture prior to in vivo administration in mice with fibrotic lungs. Important goals are to determine if engrafted cells proliferate and repair/regenerate damaged lung tissue. The effect of small molecule inhibitors of key signaling pathways in the airway fibrotic process will also be examined in these studies that may lead to novel therapies for patients with airway injury and fibrosis.


Selected Publications


Henderson WR Jr, Chi EY, Bollinger JG, et al. Importance of group X secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model. J Exp Med. 2007; 204: 865-77.
PubMed Abstract


Peters-Golden M, Henderson WR Jr. Leukotrienes. N Engl J Med. 2007; 357: 1841-54.
PubMed Abstract


Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P, Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008; 28: 546-58.
PubMed Abstract


Hallstrand TS, Wurfel MM, Lai Y, Ni Z, Gelb MH, Altemeier WA, Beyer RP, Aitken ML, Henderson WR. Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes. PLoS One. 2010; 5: e8583.
PubMed Abstract


Henderson WR Jr, Chi EY, Ye X, et al. Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis. Proc Natl Acad Sci U S A. 2010; 107: 14309-14.
PubMed Abstract


Banerjee ER, Laflamme MA, Papayannopoulou T, Kahn M, Murry CE, Henderson WR Jr. Human embryonic stem cells differentiated to lung lineage-specific cells ameliorate pulmonary fibrosis in a xenograft transplant mouse model. PLoS One. 2012; 7: e33165.
doi: 10.1371/journal.pone.0033165. PMID: 22470441
PubMed Abstract


Henderson WR Jr, Ye X, Lai Y,et al. Key role of group V secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. PLoS One. 2013; 8: e56172. doi: 10.1371/journal.pone.0056172. PMID: 23451035
PubMed Abstract

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