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Directory >> Michael G. Katze, PhD

Faculty

Contact Information

Michael G. Katze, PhD

  • Associate Director, Washington National Primate Research Center
  • Professor, Department of Microbiology
  • University of Washington

Research in the Katze lab is focused on the use of systems biology approaches to define and model virus-host interactions, innate immune signaling, and the varied strategies used by viruses to evade cellular defense mechanisms. The lab studies a wide range of viral pathogens, including influenza virus, SARS and MERS coronaviruses, Ebola virus, and human and simian immunodeficiency viruses. The group is also spearheading efforts to develop genomic resources for nonhuman primate, ferret, and Syrian hamster models of human virus infection.

Research projects in the laboratory include:

  • Division of Nonhuman Primate Systems Biology at the Washington National Primate Research Center; focused on developing genomic and immunologic resources to enhance the use of nonhuman primates as models for human virus infection.

  • Nonhuman Primate Core Functional Genomics Laboratory for AIDS Vaccine Research and Development; an NIAID contract-supported program to measure vaccine responses at the molecular level and to discover markers that may be prognostic in assessing if a vaccination will protect against HIV.

  • Nonhuman primate reference transcriptome resources; uses next-generation sequencing technologies to generate information about the structure of nonhuman primate genomes and the diversity of transcripts that these genomes express

  • Transcriptome resources for comparative primate models of lentivirus Infection; focused on generating whole-transcriptome reference databases for immune cell types at baseline and during infection with HIV or SIV with an emphasis on comparative models of pathogenic and non-pathogenic infection

  • Systems immunogenetics in the mouse Collaborative Cross; uses Collaborative Cross recombinant inbred mouse lines to identify genes and gene networks that regulate the induction, kinetics, and magnitude of innate, inflammatory, and adaptive immune responses following respiratory virus infection.

  • Center for Research in Diagnostics and Discovery; focused on the use of host-response signatures to rapidly identify emergent pathogens and to guide medical treatments to contain outbreaks.

Selected Publications

Josset, L., H. Zeng, S.M. Kelly, T.M. Tumpey, and M.G. Katze. 2014. Transcriptomic characterization of the novel avian-origin influenza A (H7N9) virus: specific host response and responses intermediate between avian (H5N1 and H7N7) and human (H3N2) viruses and implications for treatment options. mBio. 5(1):e01102-13.
PubMed Abstract


Palermo, R.E., J. Tisoncik-Go, M.J. Korth, and M.G. Katze. 2013. Old world monkeys and new age science: the evolution of nonhuman primate systems virology. ILAR J. 54:166-180.  
PubMed Abstract


Tchitchek, N. A.J. Eisfeld, J. Tosoncik-Go, L. Josset, L.E. Gralinski, C. Bécavin, S.C. Tilton, B.-J. Webb-Robertson, M.T. Ferris, A.L. Totura, C. Li, G. Neumann, T.O. Metz, R.D. Smith, K.M. Waters, R. Baric, Y. Kawaoka, and M.G. Katze. 2013. Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice. BMC Syst. Biol. 7:69.
PubMed Abstract


Law, G.L., M.J. Korth, A.G. Benecke, and M.G. Katze. 2013. Systems virology: host-directed approaches to viral pathogenesis and drug targeting. Nature Rev. Microbiol. 11:455-466.
PubMed Abstract


Josset, L., V.D. Menachery, L.E. Gralinski, S. Agnihothram, P. Sova, V.S. Carter, B.L. Yount, R.L. Graham, R.S. Baric, and M.G. Katze. 2013. Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus. mBio 4(3) e00165-13.
PubMed Abstract


Chang, S.T., M.J. Thomas, P. Sova, R.R. Green, R.E., Palermo, and M.G. Katze. 2013. Next-generation sequencing of small RNAs from HIV-infected cells identifies phased microRNA expression patterns and candidate novel microRNAs differentially expressed upon infection. mBio. 4(1):e00549-12.
PubMed Abstract

 

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