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Directory >> Seymour J. Klebanoff, MD, PhD

Faculty

Seymour J. Klebanoff, MD, PhD

  • Professor Emeritus, Department of Medicine

Research is directed at elucidating the mechanisms of the host defense against microbial invasion, with emphasis on the mechanisms by which phagocytes destroy pathogenic organisms. Emphasis is on the role of phagocyte-derived oxidants, particularly those formed by the myeloperoxidase-H2O2-halide system. Although emphasis is on the phagocyte rather than the microbe, some studies deal with the destruction of special pathogens (e.g., HIV). H2O2 can be generated by certain microorganisms, including strains of lactobacilli, and the H2O2 so formed contributes to the control of infections in the vagina where H2O2-generating lactobacilli are a normal component of the microbial flora. Studies deal with the role of the lactobacillus-peroxidase system in the control of vaginal infections, particularly bacterial vaginosis. Studies are underway dealing with the characterization of factors released by strains of staphylococci which activate NFkB, induce cytokine release, and activate the HIV-1 LTR in cells of macrophage lineage and, thus, may play a role in the pathogenesis of infections induced by these organisms. Dr. Klebanoff collaborates with Drs. Rosen, Hawn, and Van Voorhis.


Selected Publications


Klebanoff SJ, Watts DH, Mehlin C, Headley CM. Lactobacilli and vaginal host defense: activation of the human immunodeficiency virus type 1 long terminal repeat, cytokine production, and NF-kappaB. J Infect Dis. 1999; 179: 653-60.
PubMed Abstract


Mehlin C, Headley CM, Klebanoff SJ. An inflammatory polypeptide complex from Staphylococcus epidermidis: isolation and characterization. J Exp Med. 1999; 189: 907-18.
PubMed Abstract


Otto M, O'Mahoney DS, Guina T, Klebanoff SJ. Activity of Staphylococcus epidermidis phenol-soluble modulin peptides expressed in Staphylococcus carnosus. J Infect Dis. 2004; 190: 748-55.
PubMed Abstract


Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005; 77: 598-625.
PubMed Abstract

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