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Directory >> Jeanne M. Marrazzo, MD, MPH


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Jeanne M. Marrazzo, MD, MPH

  • Professor, Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington

Current research is centered in several areas:

  • Biomedical prevention of HIV, especially evaluation of vaginal and oral pre-exposure prophylaxis (PrEP) for prevention of HIV acquisition in African women;
  • Interactions between hormonal contraceptives and cervicovaginal inflammation and infection;
  • Molecular epidemiology of vaginal the vaginal microbiome, including bacterial vaginosis (BV), and role of newly defined bacteria in the pathogenesis and diagnosis of BV;
  • Sexually transmitted infections and health care seeking behavior in LGBTQ populations, including STD in men who have sex with men and in HIV care settings, cervical neoplasia and BV in women who report sex with women;
  • Diagnosis and epidemiology of bacterial STDs.
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome, local immunity and HIV shedding in Kenyan women.
  • Evaluation of a contraceptive vaginal ring on the vaginal microbiome and local immunity in U.S. women.

Our work has expanded the microbiologic spectrum of BV-associated organisms, and we continue to study predictors of infection with these bacteria, their role in diagnosis of vaginal infections, the host immune response in BV, and potential reservoirs (including sex partners) that may help explain BVs association with specific sexual practices. We are also very interested in the effects that different types of hormonal contraception may have on the genital microbiome and on risk of and activity of critical genital infections, including genital herpes.

The major objectives of work related to HIV PrEP is to evaluate the effectiveness of oral vs. vaginally delivered antiretroviral medications in preventing HIV acquisition in young HIV-uninfected women in sub-Saharan Africa. Research related to other STDs seeks to define better point-of-care diagnostic tests for common pathogens. Collaborators in these efforts include Dr. David Fredricks, Dr. Thomas Hawn, Dr. Jared Baeten, and Dr. Connie Celum.

As the Medical Director of the Seattle STD/HIV Prevention Training Center, I am also invested in delivering and evaluating excellent educational offerings to providers in practice and to medical practitioners in training. See for more information.

Selected Publications

Gorgos Linda M, Sycuro LK, Srinivasan S, Fiedler TL, Morgan MT, Balkus JE, McClelland RS, Fredricks DN, Marrazzo JM. Relationship of specific bacteria in the cervical and vaginal microbiotas with cervicitis. Sex Transm Dis [in press].

Noguchi LM, Richardson BA, Baeten JM, Hillier SL, Balkus JE, Chirenje ZM, Bunge K, Ramjee G, Nair G, Palanee-Phillips T, Selepe P, van der Straten A, Parikh UM, Gomez K, Piper JM, Watts H, Marrazzo JM. Risk of HIV-1 acquisition among women using different types of injectable progestin contraception in South Africa: a prospective cohort study. Lancet HIV.
The Lancet HIV Abstract

Marrazzo JM, Richardson B, Ramjee G, et al, for the VOICE (MTN 003) Team. Tenofovir-based preexposure prophylaxis for HIV infection among African women. New Engl J Med 2015;372(6):509-18. PMID 25651245
The New England Journal of Medicine Abstract

Marrazzo JM, del Rio C, Holtgrave D, et al. Combination HIV prevention in clinical care settings in 2014: recommendations of an International Antiviral Society-USA Panel. JAMA 2014;312:390-409.
PubMed Abstract

Marrazzo JM, Fiedler T, Srinavasan S, et al. Extravaginal reservoirs of vaginal bacteria as risk factors for bacterial vaginosis. J Infect Dis. 2012; 205(10): 1580-8.
PubMed Abstract

Mitchell C, Manhart LE, Thomas KK, Agnew K, Marrazzo JM. Effect of sexual activity on vaginal colonization with hydrogen peroxide-producing lactobacilli and Gardnerella vaginalis. Sex Transm Dis. 2011; 38(12): 1137-44. PMCID: PMC3217189.
PubMed Abstract

Marrazzo JM, Cates W. Interventions to prevent sexually transmitted infections, including HIV infection. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. Clin Infect Dis. 2011; 53(Suppl 3): S64-78. PMCID: PMC3213401.
PubMed Abstract

Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med. 2005; 353(18): 1899-911.
PubMed Abstract

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