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Directory >> Chetan Seshadri, MD


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Chetan Seshadri, MD

  • Assistant Professor , Division of Allergy and Infectious Diseases, Department of Medicine
    University of Washington
    Associate Medical Staff
    University of Washington Medical Center and Harborview Medical Center

Dr. Seshadri's research focuses on the human immune response to Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By better understanding what factors are responsible for protective immunity, he hopes to contribute to ongoing efforts to develop an effective vaccine. Specifically, his work addresses two questions:

  • What is the role of T-cells that respond to lipids and small molecules produced by bacteria?
  • Why do some people fail to convert their tuberculin skin tests despite frequent and close contact with tuberculosis patients?

The Seshadri Lab is located within the UW Medicine South Lake Union campus. Research methods include basic cellular and molecular immunology as well as high-throughput transcriptional and genetic analysis of affected populations. Dr. Seshadri has active collaborations with investigators in the United States, France, Vietnam, South Africa, and Uganda.

Selected Publications

Seshadri C, Thuong NT, Yen NT, Bang ND, Chau TT, Thwaites GE, Dunstan SJ, Hawn TR. A polymorphism in human CD1A is associated with susceptibility totuberculosis. Genes Immun. 2014 Apr-May;15(3):195-8. doi: 10.1038/gene.2014.5.Epub 2014 Feb 6. PubMed PMID: 24500401; PubMed Central PMCID: PMC3998877.
PubMed Abstract

Seshadri C, Shenoy M, Wells RD, Hensley-McBain T, Andersen-Nissen E, McElrath MJ, Cheng TY, Moody DB, Hawn TR. Human CD1a deficiency is common and genetically regulated. J Immunol. 2013 Aug 15;191(4):1586-93. doi: 10.4049/jimmunol.1300575. Epub 2013 Jul 15. PubMed PMID: 23858036; PubMed Central PMCID: PMC3748949.
PubMed Abstract

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis. J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667. Epub 2012 Nov 28. PubMed PMID: 23197260; PubMed Central PMCID: PMC3529834.
PubMed Abstract

Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB. CD1b tetramers bind aß T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug 29;208(9):1741-7. doi: 10.1084/jem.20110665. Epub 2011 Aug 1. PubMed PMID: 21807869; PubMed Central PMCID: PMC3171094.
PubMed Abstract

Drage MG, Tsai HC, Pecora ND, Cheng TY, Arida AR, Shukla S, Rojas RE, Seshadri C, Moody DB, Boom WH, Sacchettini JC, Harding CV. Mycobacterium tuberculosis lipoprotein LprG (Rv1411c) binds triacylated glycolipid agonists of Toll-like receptor 2. Nat Struct Mol Biol. 2010 Sep;17(9):1088-95. doi: 10.1038/nsmb.1869. Epub 2010 Aug 8. PubMed PMID: 20694006; PubMed Central PMCID: PMC2933325.
PubMed Abstract

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