{"id":81,"date":"2020-07-07T09:44:59","date_gmt":"2020-07-07T16:44:59","guid":{"rendered":"https:\/\/depts.washington.edu\/deworm3\/?page_id=81"},"modified":"2024-06-18T16:08:38","modified_gmt":"2024-06-18T23:08:38","slug":"study-design","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/deworm3\/about\/study-design\/","title":{"rendered":"Study Design"},"content":{"rendered":"

The DeWorm3 Study is a series of community cluster randomized controlled trials. It uses a community-wide drug administration approach to determine whether deworming both children and adults can begin to disrupt the soil-transmitted helminth (STH) transmission cycle.\u00a0 We selected sites across three countries \u2014 India, Malawi, and Benin \u2014 to conduct community cluster randomized trials comparing the school-based strategy to community-wide deworming.<\/span><\/p>\n

\"\"<\/p>\n

Community-wide drug administration<\/em>
Timiri, India\/ Mr. Rajeshkumar Rajendiran<\/em><\/span><\/p>\n<\/div>\n

\"\"<\/p>\n

School-based strategy<\/em>
Timiri, India\/ Mr. Rajeshkumar Rajendiran<\/em><\/span><\/p>\n<\/div>\n

Each trial site study involves a population of over 80,000 people divided into 40 total clusters.\u00a0 Clusters are randomized to receive either the current WHO approach providing deworming medication to school-aged children, while other clusters receive community-wide deworming across all ages.\u00a0 This two-level approach will continue for three years.\u00a0 Once this treatment is complete, no deworming will occur for two years, after which the prevalence of STH infection at each site will be examined to assess success.<\/span><\/p>\n

A number of implementation science studies will be conducted alongside the trials to address distinct and complementary questions that generate evidence of <\/span>sustainable and scalable models for soil-transmitted helminth (STH) transmission interruption.<\/p>\n

Read our trial protocols published in PLoS Neglected Tropical Diseases<\/em>:<\/h3>\n

DeWorm3 Trial Protocol<\/b><\/p>\n

Assessing the feasibility of interrupting the transmission of soil-transmitted helminths through mass drug administration: The DeWorm3 cluster randomized trial protocol<\/span><\/a><\/p>\n

\u00c1sbj\u00f6rnsd\u00f3ttir et al. (2018)<\/em><\/p>\n

 <\/p>\n

DeWorm3 Implementation Science Protocol<\/b><\/p>\n

Evaluating the sustainability, scalability, and replicability of an STH transmission interruption intervention: The DeWorm3 implementation science protocol<\/span><\/a><\/p>\n

Means et al. (2018)<\/em><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

The DeWorm3 Study is a series of community cluster randomized controlled trials. It uses a community-wide drug administration approach to determine whether deworming both children and adults can begin to disrupt the soil-transmitted helminth (STH) transmission cycle.\u00a0 We selected sites across three countries \u2014 India, Malawi, and Benin \u2014 to conduct community cluster randomized trials…<\/p>\n

Read more<\/a><\/div>\n","protected":false},"author":2,"featured_media":0,"parent":684,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-81","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/pages\/81","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/comments?post=81"}],"version-history":[{"count":24,"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/pages\/81\/revisions"}],"predecessor-version":[{"id":1145,"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/pages\/81\/revisions\/1145"}],"up":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/pages\/684"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/deworm3\/wp-json\/wp\/v2\/media?parent=81"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}