Rebecca Hull-Meichle

Research Professor

VA Puget Sound Health Care System



Research Interest: Pathophysiology and Treatment of Type 2 Diabetes

DRC Publications

Meier, DT; Entrup, L; Templin, AT; Hogan, MF; Mellati, M; Zraika, S; Hull, RL; Kahn, SE ; The S20G substitution in hIAPP is more amyloidogenic and cytotoxic than wild-type hIAPP in mouse islets Diabetologia 59 10: 2166-71; 2016 PMC5026922

Hogan, MF; Meier, DT; Zraika, S; Templin, AT; Mellati, M; Hull, RL; Leissring, MA; Kahn, SE ; Inhibition of Insulin-Degrading Enzyme Does Not Increase Islet Amyloid Deposition In Vitro Endocrinology en20161410; 2016

Mundinger, TO; Mei, Q; Foulis, AK; Fligner, CL; Hull, RL; Taborsky, GJ, Jr. ; Human Type 1 Diabetes Is Characterized by an Early, Marked, Sustained, and Islet-Selective Loss of Sympathetic Nerves Diabetes 65 8: 2322-30; 2016 PMC4955989

Meier, DT; Tu, LH; Zraika, S; Hogan, MF; Templin, AT; Hull, RL; Raleigh, DP; Kahn, SE ; Matrix Metalloproteinase-9 Protects Islets from Amyloid-induced Toxicity J Biol Chem 290 51: 30475-85; 2015 PMC4683269

Hull, RL; Bogdani, M; Nagy, N; Johnson, PY; Wight, TN ; Hyaluronan: A mediator of islet dysfunction and destruction in diabetes? J Histochem Cytochem 63 8: 592-603; 2015 PMC4530396

Brissova, M; Shostak, A; Fligner, CL; Revetta, FL; Washington, MK; Powers, AC; Hull, RL ; Human islets have fewer blood vessels than mouse islets and the density of islet vascular structures is increased in type 2 diabetes J Histochem Cytochem 63 8: 637-45; 2015 PMC4530394

Hogan, MF; Ravnskjaer, K; Matsumura, S; Huising, MO; Hull, RL; Kahn, SE; Montminy, M ; Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2 J Biol Chem 290 43: 25997-6006; 2015 PMC4646253

Meier, DT; Morcos, M; Samarasekera, T; Zraika, S; Hull, RL; Kahn, SE ; Islet amyloid formation is an important determinant for inducing islet inflammation in high-fat-fed human IAPP transgenic mice Diabetologia 57 9: 1884-8; 2014 PMC4267509

Udayasankar, J; Zraika, S; Aston-Mourney, K; Subramanian, SL; Brooks-Worrell, BM; Taborsky, GJ; Hull, RL ; Rosiglitazone treatment does not decrease amyloid deposition in transplanted islets from transgenic mice expressing human islet amyloid polypeptide Transplant Proc 45 2: 574-9; 2013 PMC3602214

Aston-Mourney, K; Subramanian, SL; Zraika, S; Samarasekera, T; Meier, DT; Goldstein, LC; Hull, RL ; One year of sitagliptin treatment protects against islet amyloid-associated beta-cell loss and does not induce pancreatitis or pancreatic neoplasia in mice Am J Physiol Endocrinol Metab 305 4: E475-84; 2013 PMC3891222

Aston-Mourney, K; Zraika, S; Udayasankar, J; Subramanian, SL; Green, PS; Kahn, SE; Hull, RL ; Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide J Biol Chem 288 5: 3553-9; 2013 PMC3561574

Rountree, AM; Reed, BJ; Cummings, BP; Jung, SR; Stanhope, KL; Graham, JL; Griffen, SC; Hull, RL; Havel, PJ; ... Sweet, IR Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes Diabetologia 56 4: 803-13; 2013 PMC3855025

Bollyky, PL; Bogdani, M; Bollyky, JB; Hull, RL; Wight, TN ; The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation Curr Diab Rep 12 5: 471-80; 2012 PMC3432646

Hull, RL; Peters, MJ; Perigo, SP; Chan, CK; Wight, TN; Kinsella, MG ; Overall sulfation of heparan sulfate from pancreatic islet beta-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide J Biol Chem 287 44: 37154-64; 2012 PMC3481315

Hull, RL; Johnson, PY; Braun, KR; Day, AJ; Wight, TN ; Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types J Histochem Cytochem 60 10: 749-60; 2012 PMC3524560

Subramanian, SL; Hull, RL; Zraika, S; Aston-Mourney, K; Udayasankar, J; Kahn, SE ; cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets Diabetologia 55 1: 166-74; 2012 PMC3249975

Aston-Mourney, K; Hull, RL; Zraika, S; Udayasankar, J; Subramanian, SL; Kahn, SE ; Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets Diabetologia 54 7: 1756-65; 2011 PMC3220951