{"id":8596,"date":"2021-08-18T16:13:20","date_gmt":"2021-08-18T23:13:20","guid":{"rendered":"https:\/\/depts.washington.edu\/diabetes\/?p=8596"},"modified":"2021-08-18T16:17:24","modified_gmt":"2021-08-18T23:17:24","slug":"karin-bornfeldt-ph-d-co-authored-a-review-in-cell-metabolism","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/diabetes\/karin-bornfeldt-ph-d-co-authored-a-review-in-cell-metabolism\/","title":{"rendered":"Karin Bornfeldt, Ph.D., co-authored a review in Cell Metabolism"},"content":{"rendered":"<section class=\"kc-elm kc-css-235010 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-124262 kc_col-sm-3 kc_column kc_col-sm-3\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-865767 kc_text_block\"><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full\" src=\"https:\/\/depts.washington.edu\/diabetes\/wp-content\/uploads\/2016\/10\/Bornfeldt-Karin_2.jpg\" alt=\"\" width=\"200\" height=\"301\"\/><\/p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-877443 kc_col-sm-9 kc_column kc_col-sm-9\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-44761 kc_text_block\"><p>Karin Bornfeldt, deputy director of the DRC, co-authored a review in Cell Metabolism, \u201cCardiovascular disease in diabetes, beyond glucose.\u201d<\/p>\n<p><strong>Abstract:<\/strong><br \/>Despite the decades-old knowledge that diabetes mellitus is a major risk factor for cardiovascular disease, the reasons for this association are only partially understood. While this association is true for both type 1 and type 2 diabetes, different pathophysiological processes may be responsible. Lipids and other risk factors are indeed important, whereas the role of glucose is less clear. This lack of clarity stems from clinical trials that do not unambiguously show that intensive\u00a0glycemic control\u00a0reduces cardiovascular events. Animal models have provided mechanisms that link diabetes to increased\u00a0atherosclerosis, and evidence consistent with the importance of factors beyond\u00a0hyperglycemia\u00a0has emerged. We review clinical, pathological, and animal studies exploring the pathogenesis of atherosclerosis in humans living with diabetes and in mouse models of diabetes. An increased effort to identify risk factors beyond glucose is now needed to prevent the increased cardiovascular disease risk associated with diabetes.<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S155041312100317X?dgcid=coauthor\">Article Link<\/a><\/p>\n<p><!-- \/wp:post-content --><\/p>\n<\/div><\/div><\/div><\/div><\/div><\/section><!-- \/wp:freeform -->","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"footnotes":""},"categories":[20],"tags":[],"class_list":["post-8596","post","type-post","status-publish","format-standard","hentry","category-diabetes-research-center-related-news"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/posts\/8596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/comments?post=8596"}],"version-history":[{"count":8,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/posts\/8596\/revisions"}],"predecessor-version":[{"id":8614,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/posts\/8596\/revisions\/8614"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/media?parent=8596"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/categories?post=8596"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/diabetes\/wp-json\/wp\/v2\/tags?post=8596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}