Publications from NDRG PIs

Afzal MZ, Reiter M, Gastonguay C, McGivern JV, Guan X, Ge Z-D, Mack DL, Childers MK, Ebert AD & Strande JL (2016) Nicorandil, a Nitric Oxide Donor and ATP-Sensitive Potassium Channel Opener, Protects Against Dystrophin-Deficient Cardiomyopathy. J. Cardiovasc. Pharmacol. Ther. 21, 549–562.

Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, Aghajanian GK & Jaenisch R (2001) Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Mol. Psychiatry 6, 593–604.

Alpers CE, Hudkins KL, Ferguson M, Johnson RJ, Schatteman GC & Bothwell M (1993) Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys. Lab. Invest. 69, 703–713.

Augustin V & Kins S (2021) Fe65: A scaffolding protein of actin regulators. Cells 10.

Barabás K, Kobolák J, Godó S, Kovács T, Ernszt D, Kecskés M, Varga C, Jánosi TZ, Fujiwara T, Kusumi A, Téglási A, Dinnyés A & Ábrahám IM (2021) Live-Cell Imaging of Single Neurotrophin Receptor Molecules on Human Neurons in Alzheimer’s Disease. Int. J. Mol. Sci. 22.

von Bartheld CS & Bothwell M (1992) Development and distribution of noradrenergic and cholinergic neurons and their trophic phenotypes in the avian ceruleus complex and midbrain tegmentum. J. Comp. Neurol. 320, 479–500.

von Bartheld CS & Bothwell M (1993) Development of the mesencephalic nucleus of the trigeminal nerve in chick embryos: target innervation, neurotrophin receptors, and cell death. J. Comp. Neurol. 328, 185–202.

von Bartheld CS, Byers MR, Williams R & Bothwell M (1996) Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system. Nature 379, 830–833.

von Bartheld CS, Heuer JG & Bothwell M (1991) Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: comparison with cholinergic development. J. Comp. Neurol. 310, 103–129.

von Bartheld CS, Kinoshita Y, Prevette D, Yin QW, Oppenheim RW & Bothwell M (1994) Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos. Neuron 12, 639–654.

von Bartheld CS, Patterson SL, Heuer JG, Wheeler EF, Bothwell M & Rubel EW (1991) Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat. Development 113, 455–470.

von Bartheld CS, Schober A, Kinoshita Y, Williams R, Ebendal T & Bothwell M (1995) Noradrenergic neurons in the locus coeruleus of birds express TrkA, transport NGF, and respond to NGF. J. Neurosci. 15, 2225–2239.

von Bartheld CS, Williams R, Lefcort F, Clary DO, Reichardt LF & Bothwell M (1996) Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J. Neurosci. 16, 2995–3008.

Belinskaia DA, Voronina PA, Shmurak VI, Vovk MA, Batalova AA, Jenkins RO & Goncharov NV (2020) The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin. Antioxidants (Basel) 9.

Berry BJ, Akanda N, Smith AST, Long CJ, Schnepper MT, Guo X & Hickman JJ (2015) Morphological and functional characterization of human induced pluripotent stem cell-derived neurons (iCell Neurons) in defined culture systems. Biotechnol. Prog. 31, 1613–1622.

Berry BJ, Smith AST, Long CJ, Martin CC & Hickman JJ (2018) Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer’s Disease Phenotype in iPSC Derived Human Neurons. ACS Chem. Neurosci. 9, 1693–1701.

Berry BJ, Smith AST, Young JE & Mack DL (2018) Advances and current challenges associated with the use of human induced pluripotent stem cells in modeling neurodegenerative disease. Cells Tissues Organs (Print), 1–19.

Bertero A, Fields PA, Smith AST, Leonard A, Beussman K, Sniadecki NJ, Kim D-H, Tse H-F, Pabon L, Shendure J, Noble WS & Murry CE (2019) Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy. J. Cell Biol. 218, 2919–2944.

Block T & Bothwell M (1983) The nerve growth factor receptor on PC12 cells: interconversion between two forms with different binding properties. J. Neurochem. 40, 1654–1663.

Booth BW, Mack DL, Androutsellis-Theotokis A, McKay RDG, Boulanger CA & Smith GH (2008) The mammary microenvironment alters the differentiation repertoire of neural stem cells. Proc Natl Acad Sci USA 105, 14891–14896.

Borson S, Schatteman G, Claude P & Bothwell M (1994) Neurotrophins in the developing and adult primate adenohypophysis: a new pituitary hormone system? Neuroendocrinology 59, 466–476.

Bothwell M (2006) Evolution of the neurotrophin signaling system in invertebrates. Brain Behav. Evol. 68, 124–132.

Bothwell M (1995) Functional interactions of neurotrophins and neurotrophin receptors. Annu. Rev. Neurosci. 18, 223–253.

Bothwell M (1982) Insulin and somatemedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons. J. Neurosci. Res. 8, 225–231.

Bothwell M (1991) Keeping track of neurotrophin receptors. Cell 65, 915–918.

Bothwell M (2017) Mechanisms and medicines for remyelination. Annu. Rev. Med. 68, 431–443.

Bothwell M (1997) Neurotrophin function in skin. J. Investig. Dermatol. Symp. Proc. 2, 27–30.

Bothwell M (2014) NGF, BDNF, NT3, and NT4. Handb. Exp. Pharmacol. 220, 3–15.

Bothwell M (1996) p75NTR: a receptor after all. Science 272, 506–507.

Bothwell M (2019) Recent advances in understanding context-dependent mechanisms controlling neurotrophin signaling and function. [version 1; peer review: 3 approved]. F1000Res. 8.

Bothwell M (2016) Recent advances in understanding neurotrophin signaling. [version 1; peer review: 2 approved]. F1000Res. 5.

Bothwell M & Block T (1986) Use of iron- or selenium-coupled monoclonal antibodies to cell surface antigens as a positive selection system for cells. Meth. Enzymol. 121, 771–783.

Bothwell M & Giniger E (2000) Alzheimer’s disease: neurodevelopment converges with neurodegeneration. Cell 102, 271–273.

Bothwell M & Schachman HK (1974) Pathways of assembly of aspartate transcarbamoylase from catalytic and regulatory subunits. Proc Natl Acad Sci USA 71, 3221–3225.

Bothwell MA & Datta P (1971) Effects of K+ on the catalytic and regulatory properties of homoserine dehydrogenase of Pseudomonas fluorescens. Biochim. Biophys. Acta 235, 1–13.

Bothwell MA, Howlett GJ & Schachman HK (1978) A sedimentation equilibrium method for determining molecular weights of proteins with a tabletop high speed air turbine centrifuge. J. Biol. Chem. 253, 2073–2077.

Bothwell MA & Schachman HK (1980a) A model for the assembly of aspartate transcarbamoylase from catalytic and regulatory subunits. J. Biol. Chem. 255, 1971–1977.

Bothwell MA & Schachman HK (1980b) Equilibrium and kinetic studies of the association of catalytic and regulatory subunits of aspartate transcarbamoylase. J. Biol. Chem. 255, 1962–1970.

Bothwell MA, Schechter AL & Vaughn KM (1980) Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor. Cell 21, 857–866.

Bothwell MA & Shooter EM (1977) Dissociation equilibrium constant of beta nerve growth factor. J. Biol. Chem. 252, 8532–8536.

Bothwell MA & Shooter EM (1978) Thermodynamics of interaction of the subunits of 7 S nerve growth factor. The mechanism of activation of the esteropeptidase activity by chelators. J. Biol. Chem. 253, 8458–8464.

Bothwell MA, Wilson WH & Shooter EM (1979) The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland. J. Biol. Chem. 254, 7287–7294.

Boulanger CA, Bruno RD, Mack DL, Gonzales M, Castro NP, Salomon DS & Smith GH (2013) Embryonic stem cells are redirected to non-tumorigenic epithelial cell fate by interaction with the mammary microenvironment. PLoS ONE 8, e62019.

Boulanger CA, Mack DL, Booth BW & Smith GH (2007) Interaction with the mammary microenvironment redirects spermatogenic cell fate in vivo. Proc Natl Acad Sci USA 104, 3871–3876.

Brahimi F, Galan A, Siegel S, Szobota S, Sarunic MV, Foster AC & Saragovi HU (2021) Therapeutic Neuroprotection by an Engineered Neurotrophin that Selectively Activates Tropomyosin Receptor Kinase (Trk) Family Neurotrophin Receptors but Not the p75 Neurotrophin Receptor. Mol. Pharmacol. 100, 491–501.

Braun R, Wang Z, Mack DL & Childers MK (2014) Gene therapy for inherited muscle diseases: where genetics meets rehabilitation medicine. Am. J. Phys. Med. Rehabil. 93, S97-107.

Breakefield XO, Ozelius L, Bothwell MA, Chao MV, Axelrod F, Kramer PL, Kidd KK, Lanahan AA, Johnson DE & Ross AH (1986) DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Mol. Biol. Med. 3, 483–494.

Bremner SB, Gaffney KS, Sniadecki NJ & Mack DL (2022) A change of heart: human cardiac tissue engineering as a platform for drug development. Curr. Cardiol. Rep. 24, 473–486.

Bremner SB, Mandrycky CJ, Leonard A, Padgett RM, Levinson AR, Rehn ES, Pioner JM, Sniadecki NJ & Mack DL (2022) Full-length dystrophin deficiency leads to contractile and calcium transient defects in human engineered heart tissues. J. Tissue Eng. 13, 20417314221119628.

Buechler MB, Pradhan RN, Krishnamurty AT, Cox C, Calviello AK, Wang AW, Yang YA, Tam L, Caothien R, Roose-Girma M, Modrusan Z, Arron JR, Bourgon R, Müller S & Turley SJ (2021) Cross-tissue organization of the fibroblast lineage. Nature 593, 575–579.

Burke MA & Bothwell M (2003) p75 neurotrophin receptor mediates neurotrophin activation of NF-kappa B and induction of iNOS expression in P19 neurons. J. Neurobiol. 55, 191–203.

Byers MR, Kvinnsland I & Bothwell M (1992) Analysis of low affinity nerve growth factor receptor during pulpal healing and regeneration of myelinated and unmyelinated axons in replanted teeth. J. Comp. Neurol. 326, 470–484.

Byers MR, Schatteman GC & Bothwell M (1990) Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity. Development 109, 461–471.

Byers MR, Wheeler EF & Bothwell M (1992) Altered expression of NGF and P75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting. Growth Factors 6, 41–52.

Carson D, Hnilova M, Yang X, Nemeth CL, Tsui JH, Smith AST, Jiao A, Regnier M, Murry CE, Tamerler C & Kim D-H (2016) Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells. ACS Appl. Mater. Interfaces 8, 21923–21932.

Chalazonitis A, Pham TD, Rothman TP, DiStefano PS, Bothwell M, Blair-Flynn J, Tessarollo L & Gershon MD (2001) Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J. Neurosci. 21, 5620–5636.

Chang ACY, Pardon G, Chang ACH, Wu H, Ong S-G, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL & Blau HM (2021) Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes. Stem Cell Reports 16, 2169–2181.

Chao MV & Bothwell M (2002) Neurotrophins: to cleave or not to cleave. Neuron 33, 9–12.

Chao MV, Bothwell MA, Ross AH, Koprowski H, Lanahan AA, Buck CR & Sehgal A (1986) Gene transfer and molecular cloning of the human NGF receptor. Science 232, 518–521.

Cheah LC, Stark T, Adamson LSR, Abidin RS, Lau YH, Sainsbury F & Vickers CE (2021) Artificial Self-assembling Nanocompartment for Organizing Metabolic Pathways in Yeast. ACS Synth. Biol. 10, 3251–3263.

Childers MK, Joubert R, Poulard K, Moal C, Grange RW, Doering JA, Lawlor MW, Rider BE, Jamet T, Danièle N, Martin S, Rivière C, Soker T, Hammer C, Van Wittenberghe L, Lockard M, Guan X, Goddard M, Mitchell E, Barber J, Williams JK, Mack DL, Furth ME, Vignaud A, Masurier C, Mavilio F, Moullier P, Beggs AH & Buj-Bello A (2014) Gene therapy prolongs survival and restores function in murine and canine models of myotubular myopathy. Sci. Transl. Med. 6, 220ra10.

Choi JS, Smith AST, Williams NP, Matsubara T, Choi M, Kim J-W, Kim HJ, Choi S & Kim D-H (2020) Nanopatterned Nafion microelectrode arrays for in vitro cardiac electrophysiology. Adv. Funct. Mater. 30.

Chun C, Smith AST, Kim H, Kamenz DS, Lee JH, Lee JB, Mack DL, Bothwell M, Clelland CD & Kim D-H (2021) Astrocyte-derived extracellular vesicles enhance the survival and electrophysiological function of human cortical neurons in vitro. Biomaterials 271, 120700.

Chun SY, Mack DL, Moorefield E, Oh SH, Kwon TG, Pettenati MJ, Yoo JJ, Coppi PD, Atala A & Soker S (2015) Pdx1 and controlled culture conditions induced differentiation of human amniotic fluid-derived stem cells to insulin-producing clusters. J. Tissue Eng. Regen. Med. 9, 540–549.

Cramer KS, Karam SD, Bothwell M, Cerretti DP, Pasquale EB & Rubel EW (2002) Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. J. Comp. Neurol. 452, 51–64.

Davies RL, Grosse VA, Kucherlapati R & Bothwell M (1980) Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7. Proc Natl Acad Sci USA 77, 4188–4192.

D’Elia AV, Tell G, Russo D, Arturi F, Puglisi F, Manfioletti G, Gattei V, Mack DL, Cataldi P, Filetti S, Di Loreto C & Damante G (2002) Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors. J. Clin. Endocrinol. Metab. 87, 1376–1383.

Desole C, Gallo S, Vitacolonna A, Montarolo F, Bertolotto A, Vivien D, Comoglio P & Crepaldi T (2021) HGF and MET: from brain development to neurological disorders. Front. Cell Dev. Biol. 9, 683609.

Deyerle KL, Sims JE, Dower SK & Bothwell MA (1992) Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes. J. Immunol. 149, 1657–1665.

D’Souza GX, Rose SE, Knupp A, Nicholson DA, Keene CD & Young JE (2021) The application of in vitro-derived human neurons in neurodegenerative disease modeling. J. Neurosci. Res. 99, 124–140.

Dubey A, Rose RE, Jones DR & Saint-Jeannet J-P (2018) Generating retinoic acid gradients by local degradation during craniofacial development: One cell’s cue is another cell’s poison. Genesis 56.

Dupont J-B, Guo J, Renaud-Gabardos E, Poulard K, Latournerie V, Lawlor MW, Grange RW, Gray JT, Buj-Bello A, Childers MK & Mack DL (2020) AAV-Mediated Gene Transfer Restores a Normal Muscle Transcriptome in a Canine Model of X-Linked Myotubular Myopathy. Mol. Ther. 28, 382–393.

Esch MB, Smith AST, Prot J-M, Oleaga C, Hickman JJ & Shuler ML (2014) How multi-organ microdevices can help foster drug development. Adv. Drug Deliv. Rev. 69–70, 158–169.

Freidin MB, Tsepilov YA, Palmer M, Karssen LC, Suri P, Aulchenko YS, Williams FMK & CHARGE Musculoskeletal Working Group (2019) Insight into the genetic architecture of back pain and its risk factors from a study of 509,000 individuals. Pain 160, 1361–1373.

Fry ET, Mack DL, Monge JC, Billadello JJ & Sobel BE (1990) Labeling of human clots in vitro with an active-site mutant of t-PA. J. Nucl. Med. 31, 187–191.

Fry ET, Mack DL & Sobel BE (1989) The nature of synergy between tissue-type and single chain urokinase-type plasminogen activators. Thromb. Haemost. 62, 909–916.

Fukuchi K, Hearn MG, Deeb SS, Smith AC, Dang N, Miyazaki J, Bothwell M & Martin GM (1994) Activity assays of nine heterogeneous promoters in neural and other cultured cells. In Vitro Cell Dev Biol Anim 30A, 300–305.

Garden GA, Bothwell M & Rubel EW (1991) Lack of correspondence between mRNA expression for a putative cell death molecule (SGP-2) and neuronal cell death in the central nervous system. J. Neurobiol. 22, 590–604.

Garden GA, Canady KS, Lurie DI, Bothwell M & Rubel EW (1994) A biphasic change in ribosomal conformation during transneuronal degeneration is altered by inhibition of mitochondrial, but not cytoplasmic protein synthesis. J. Neurosci. 14, 1994–2008.

Garden GA, Hartlage-Rübsamen M, Rubel EW & Bothwell MA (1995) Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death. Mol. Cell. Neurosci. 6, 293–310.

Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B & Lipton SA (2020) NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Mol. Psychiatry.

Goddard MA, Mack DL, Czerniecki SM, Kelly VE, Snyder JM, Grange RW, Lawlor MW, Smith BK, Beggs AH & Childers MK (2015) Muscle pathology, limb strength, walking gait, respiratory function and neurological impairment establish disease progression in the p.N155K canine model of X-linked myotubular myopathy. Ann. Transl. Med. 3, 262.

Grob PM, Berlot CH & Bothwell MA (1983) Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells. Proc Natl Acad Sci USA 80, 6819–6823.

Grob PM & Bothwell MA (1983) Modification of nerve growth factor receptor properties by wheat germ agglutinin. J. Biol. Chem. 258, 14136–14143.

Grob PM, Ross AH, Koprowski H & Bothwell M (1985) Characterization of the human melanoma nerve growth factor receptor. J. Biol. Chem. 260, 8044–8049.

Guan X, Goddard MA, Mack DL & Childers MK (2016) Gene therapy in monogenic congenital myopathies. Methods 99, 91–98.

Guan X, Mack DL, Moreno CM, Strande JL, Mathieu J, Shi Y, Markert CD, Wang Z, Liu G, Lawlor MW, Moorefield EC, Jones TN, Fugate JA, Furth ME, Murry CE, Ruohola-Baker H, Zhang Y, Santana LF & Childers MK (2014) Dystrophin-deficient cardiomyocytes derived from human urine: new biologic reagents for drug discovery. Stem Cell Res. 12, 467–480.

Gundersen TE & Blomhoff R (2001) Qualitative and quantitative liquid chromatographic determination of natural retinoids in biological samples. J. Chromatogr. A 935, 13–43.

Gunning PW, Landreth GE, Bothwell MA & Shooter EM (1981) Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells. J. Cell Biol. 89, 240–245.

Gunther EC, von Bartheld CS, Goodman LJ, Johnson JE & Bothwell M (2000) The G-protein inhibitor, pertussis toxin, inhibits the secretion of brain-derived neurotrophic factor. Neuroscience 100, 569–579.

Guo X, Greene K, Akanda N, Smith A, Stancescu M, Lambert S, Vandenburgh H & Hickman J (2014) In vitro Differentiation of Functional Human Skeletal Myotubes in a Defined System. Biomater. Sci. 2, 131–138.

Gupta S & Sen J (2015) Retinoic acid signaling regulates development of the dorsal forebrain midline and the choroid plexus in the chick. Development 142, 1293–1298.

Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP & Grange RW (2021a) Erratum: Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice. Mol. Ther. Methods Clin. Dev. 23, 460.

Hamm SE, Fathalikhani DD, Bukovec KE, Addington AK, Zhang H, Perry JB, McMillan RP, Lawlor MW, Prom MJ, Vanden Avond MA, Kumar SN, Coleman KE, Dupont JB, Mack DL, Brown DA, Morris CA, Gonzalez JP & Grange RW (2021b) Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice. Mol. Ther. Methods Clin. Dev. 21, 144–160.

Harris-Warrick RM, Bothwell MA & Shooter EM (1980) Subunit interactions inhibit the binding of beta nerve growth factor to receptors on embryonic chick sensory neurons. J. Biol. Chem. 255, 11284–11289.

Hatch NE, Hudson M, Seto ML, Cunningham ML & Bothwell M (2006) Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. J. Biol. Chem. 281, 27292–27305.

Hatch NE, Nociti F, Swanson E, Bothwell M & Somerman M (2005) FGF2 alters expression of the pyrophosphate/phosphate regulating proteins, PC-1, ANK and TNAP, in the calvarial osteoblastic cell line, MC3T3E1(C4). Connect. Tissue Res. 46, 184–192.

Heidemann SR, Joshi HC, Schechter A, Fletcher JR & Bothwell M (1985) Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells. J. Cell Biol. 100, 916–927.

Henry MA, Drangsholt RJ, Westrum LE & Bothwell M (1991) Localization of nerve growth factor receptor immunoreactivity in the trigeminal nucleus of kittens. Exp. Neurol. 113, 38–46.

Henry MA, Westrum LE, Bothwell M & Johnson LR (1993) Nerve growth factor receptor (p75)-immunoreactivity in the normal adult feline trigeminal system and following retrogasserian rhizotomy. J. Comp. Neurol. 335, 425–436.

Henry MA, Westrum LE, Bothwell M & Press S (1994) Electron microscopic localization of nerve growth factor receptor (p75)-immunoreactivity in pars caudalis/medullary dorsal horn of the cat. Brain Res. 642, 137–145.

Heuer JG, Fatemie-Nainie S, Wheeler EF & Bothwell M (1990) Structure and developmental expression of the chicken NGF receptor. Dev. Biol. 137, 287–304.

Hildyard JCW, Crawford AH, Rawson F, Riddell DO, Harron RCM & Piercy RJ (2020) Single-transcript multiplex in situ hybridisation reveals unique patterns of dystrophin isoform expression in the developing mammalian embryo. Wellcome Open Res. 5, 76.

Hromas R, Busse T, Carroll A, Mack D, Shopnick R, Zhang DE, Nakshatri H & Richkind K (2001) Fusion AML1 transcript in a radiation-associated leukemia results in a truncated inhibitory AML1 protein. Blood 97, 2168–2170.

Huebner K, Isobe M, Chao M, Bothwell M, Ross AH, Finan J, Hoxie JA, Sehgal A, Buck CR & Lanahan A (1986) The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. Proc Natl Acad Sci USA 83, 1403–1407.

Hutson LD & Bothwell M (2001) Expression and function of Xenopus laevis p75(NTR) suggest evolution of developmental regulatory mechanisms. J. Neurobiol. 49, 79–98.

Hyun YS, Lee J, Kim HJ, Hong YB, Koo H, Smith AST, Kim D-H, Choi B-O & Chung KW (2015) Charcot-Marie-Tooth Disease Type 4H Resulting from Compound Heterozygous Mutations in FGD4 from Nonconsanguineous Korean Families. Ann. Hum. Genet. 79, 460–469.

Iturbide A, Ruiz Tejada Segura ML, Noll C, Schorpp K, Rothenaigner I, Ruiz-Morales ER, Lubatti G, Agami A, Hadian K, Scialdone A & Torres-Padilla M-E (2021) Retinoic acid signaling is critical during the totipotency window in early mammalian development. Nat. Struct. Mol. Biol. 28, 521–532.

Iwamoto S (2002) Immunophenotype of conjunctival melanomas. Arch. Ophthalmol. 120, 1625.

Iwamoto S, Burrows RC, Agoff SN, Piepkorn M, Bothwell M & Schmidt R (2001) The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas. Am. J. Dermatopathol. 23, 288–294.

Iwamoto S, Burrows RC, Born DE, Piepkorn M & Bothwell M (2000) The application of direct immunofluorescence to intraoperative neurosurgical diagnosis. Biomol. Eng. 17, 17–22.

Iwamoto S, Burrows RC, Grossniklaus HE, Orcutt J, Kalina RE, Boehm M, Bothwell MA & Schmidt R (2002) Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas. Arch. Ophthalmol. 120, 1625–1629.

Iwamoto S, Burrows RC, Kalina RE, George D, Boehm M, Bothwell MA & Schmidt R (2002) Immunophenotypic differences between uveal and cutaneous melanomas. Arch. Ophthalmol. 120, 466–470.

Iwamoto S, Odland PB, Piepkorn M & Bothwell M (1996) Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma. J. Am. Acad. Dermatol. 35, 725–731.

Jiao A, Moerk CT, Penland N, Perla M, Kim J, Smith AST, Murry CE & Kim D-H (2018) Regulation of skeletal myotube formation and alignment by nanotopographically controlled cell-secreted extracellular matrix. J. Biomed. Mater. Res. A 106, 1543–1551.

Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M & Chao M (1986) Expression and structure of the human NGF receptor. Cell 47, 545–554.

Kanning KC, Hudson M, Amieux PS, Wiley JC, Bothwell M & Schecterson LC (2003) Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J. Neurosci. 23, 5425–5436.

Karam SD, Burrows RC, Logan C, Koblar S, Pasquale EB & Bothwell M (2000) Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. J. Neurosci. 20, 6488–6500.

Karam SD, Dottori M, Ogawa K, Henderson JT, Boyd AW, Pasquale EB & Bothwell M (2002) EphA4 is not required for Purkinje cell compartmentation. Brain Res. Dev. Brain Res. 135, 29–38.

Karam SD, Kim YS & Bothwell M (2001) Granule cells migrate within raphes in the developing cerebellum: an evolutionarily conserved morphogenic event. J. Comp. Neurol. 440, 127–135.

Keles GE, Berger MS, Schofield D & Bothwell M (1993) Nerve growth factor receptor expression in medulloblastomas and the potential role of nerve growth factor as a differentiating agent in medulloblastoma cell lines. Neurosurgery 32, 274–80; discussion 280.

Kinoshita Y, Kinoshita C, Heuer JG & Bothwell M (1993) Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture. Development 119, 943–956.

Klima JC, Doyle LA, Lee JD, Rappleye M, Gagnon LA, Lee MY, Barros EP, Vorobieva AA, Dou J, Bremner S, Quon JS, Chow CM, Carter L, Mack DL, Amaro RE, Vaughan JC, Berndt A, Stoddard BL & Baker D (2021) Incorporation of sensing modalities into de novo designed fluorescence-activating proteins. Nat. Commun. 12, 856.

Klimmt J, Dannert A & Paquet D (2020) Neurodegeneration in a dish: advancing human stem-cell-based models of Alzheimer’s disease. Curr. Opin. Neurobiol. 61, 96–104.

Koblar SA, Krull CE, Pasquale EB, McLennan R, Peale FD, Cerretti DP & Bothwell M (2000) Spinal motor axons and neural crest cells use different molecular guides for segmental migration through the rostral half-somite. J. Neurobiol. 42, 437–447.

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Kullas CD, Henry MA, Westrum LE, Johnson LR & Bothwell M (1991) Retrogasserian rhizotomy causes expression of nerve growth factor receptor-immunoreactive protein in motoneurons within the adult feline trigeminal motor nucleus. Neurosci. Lett. 126, 145–148.

de Laat R, Meabon JS, Wiley JC, Hudson MP, Montine TJ & Bothwell M (2015) LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor. Pathobiol. Aging Age Relat. Dis. 5, 25796.

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Lavado A, Guo X, Smith AS, Akanda N, Martin C, Cai Y, Elbrecht D, Tran M, Bryant J-P, Colon A, Long CJ, Lambert S, Morgan D & Hickman JJ (2017) Evaluation of holistic treatment for ALS reveals possible mechanism and therapeutic potential. Int. J. Pharm. Pharm. Res. 11, 348–374.

Lee B-K, Choi S-J, Mack D & Oh S-H (2011) Isolation of mesenchymal stem cells from the mandibular marrow aspirates. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 112, e86-93.

Lichtenthaler SF, Tschirner SK & Steiner H (2022) Secretases in Alzheimer’s disease: Novel insights into proteolysis of APP and TREM2. Curr. Opin. Neurobiol. 72, 101–110.

Luttrell SM, Smith AST & Mack DL (2021) Creating stem cell-derived neuromuscular junctions in vitro. Muscle Nerve 64, 388–403.

Macadangdang J, Guan X, Smith AST, Lucero R, Czerniecki S, Childers MK, Mack DL & Kim D-H (2015) Nanopatterned Human iPSC-based Model of a Dystrophin-Null Cardiomyopathic Phenotype. Cell. Mol. Bioeng. 8, 320–332.

Mack D, Nishimura K, Dennehey BK, Arbogast T, Parkinson J, Toh-e A, Pringle JR, Bender A & Matsui Y (1996) Identification of the bud emergence gene BEM4 and its interactions with rho-type GTPases in Saccharomyces cerevisiae. Mol. Cell. Biol. 16, 4387–4395.

Mack DL (2017) Reversion to embryonic transcriptional splicing patterns may underlie diabetic myopathy. Muscle Nerve 56, 686–688.

Mack DL, Boulanger CA, Callahan R & Smith GH (2007) Expression of truncated Int6/eIF3e in mammary alveolar epithelium leads to persistent hyperplasia and tumorigenesis. Breast Cancer Res. 9, R42.

Mack DL, Cortés E, Giannini V, Török P, Roschuk T & Maier SA (2017) Decoupling absorption and emission processes in super-resolution localization of emitters in a plasmonic hotspot. Nat. Commun. 8, 14513.

Mack DL, DaSilva AW, Rogers C, Hedlund E, Murphy EI, Vojdanovski V, Plomp J, Wang W, Nepal SK, Holtzheimer PE, Wagner DD, Jacobson NC, Meyer ML, Campbell AT & Huckins JF (2021) Mental Health and Behavior of College Students During the COVID-19 Pandemic: Longitudinal Mobile Smartphone and Ecological Momentary Assessment Study, Part II. J. Med. Internet Res. 23, e28892.

Mack DL, Guan X, Wagoner A, Walker SJ & Childers MK (2014) Disease-in-a-dish: the contribution of patient-specific induced pluripotent stem cell technology to regenerative rehabilitation. Am. J. Phys. Med. Rehabil. 93, S155-68.

Mack DL, Leibowitz DS, Cooper S, Ramsey H, Broxmeyer HE & Hromas R (2002) Down-regulation of the myeloid homeobox protein Hex is essential for normal T-cell development. Immunology 107, 444–451.

Mack DL, Poulard K, Goddard MA, Latournerie V, Snyder JM, Grange RW, Elverman MR, Denard J, Veron P, Buscara L, Le Bec C, Hogrel J-Y, Brezovec AG, Meng H, Yang L, Liu F, O’Callaghan M, Gopal N, Kelly VE, Smith BK, Strande JL, Mavilio F, Beggs AH, Mingozzi F, Lawlor MW, Buj-Bello A & Childers MK (2017) Systemic AAV8-Mediated Gene Therapy Drives Whole-Body Correction of Myotubular Myopathy in Dogs. Mol. Ther. 25, 839–854.

Mandai K, Guo T, St Hillaire C, Meabon JS, Kanning KC, Bothwell M & Ginty DD (2009) LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63, 614–627.

Marano N, Dietzschold B, Earley JJ, Schatteman G, Thompson S, Grob P, Ross AH, Bothwell M, Atkinson BF & Koprowski H (1987) Purification and amino terminal sequencing of human melanoma nerve growth factor receptor. J. Neurochem. 48, 225–232.

Mason K, Peale FV, Stone JS, Rubel EW & Bothwell M (1998) Expression of novel potassium channels in the chick basilar papilla. Hear. Res. 125, 120–130.

McAleer CW, Smith AST, Najjar S, Pirozzi K, Long CJ & Hickman JJ (2014) Mechanistic investigation of adult myotube response to exercise and drug treatment in vitro using a multiplexed functional assay system. J. Appl. Physiol. 117, 1398–1405.

McCready FP, Gordillo-Sampedro S, Pradeepan K, Martinez-Trujillo J & Ellis J (2022) Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders. Biology (Basel) 11.

Meabon JS, De Laat R, Ieguchi K, Wiley JC, Hudson MP & Bothwell M (2015) LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments. J. Biol. Chem. 290, 9511–9520.

Meabon JS, de Laat R, Ieguchi K, Serbzhinsky D, Hudson MP, Huber BR, Wiley JC & Bothwell M (2016) Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling. Mol. Cell. Neurosci. 70, 1–10.

Mengsteab PY, Uto K, Smith AST, Frankel S, Fisher E, Nawas Z, Macadangdang J, Ebara M & Kim D-H (2016) Spatiotemporal control of cardiac anisotropy using dynamic nanotopographic cues. Biomaterials 86, 1–10.

Mesulam MM, Geula C, Bothwell MA & Hersh LB (1989) Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons. J. Comp. Neurol. 283, 611–633.

Mesulam MM, Mash D, Hersh L, Bothwell M & Geula C (1992) Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus. J. Comp. Neurol. 323, 252–268.

Miklas JW, Clark E, Levy S, Detraux D, Leonard A, Beussman K, Showalter MR, Smith AT, Hofsteen P, Yang X, Macadangdang J, Manninen T, Raftery D, Madan A, Suomalainen A, Kim D-H, Murry CE, Fiehn O, Sniadecki NJ, Wang Y & Ruohola-Baker H (2019) TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes. Nat. Commun. 10, 4671.

Mirmalek-Sani S-H, Orlando G, McQuilling JP, Pareta R, Mack DL, Salvatori M, Farney AC, Stratta RJ, Atala A, Opara EC & Soker S (2013) Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering. Biomaterials 34, 5488–5495.

Monaghan JR & Maden M (2012) Visualization of retinoic acid signaling in transgenic axolotls during limb development and regeneration. Dev. Biol. 368, 63–75.

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Mudera V, Smith AST, Brady MA & Lewis MP (2010) The effect of cell density on the maturation and contractile ability of muscle derived cells in a 3D tissue-engineered skeletal muscle model and determination of the cellular and mechanical stimuli required for the synthesis of a postural phenotype. J. Cell. Physiol. 225, 646–653.

Mufson EJ, Bothwell M, Hersh LB & Kordower JH (1989) Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons. J. Comp. Neurol. 285, 196–217.

Mufson EJ, Bothwell M & Kordower JH (1989) Loss of nerve growth factor receptor-containing neurons in Alzheimer’s disease: a quantitative analysis across subregions of the basal forebrain. Exp. Neurol. 105, 221–232.

Murphy SV, Skardal A, Song L, Sutton K, Haug R, Mack DL, Jackson J, Soker S & Atala A (2017) Solubilized Amnion Membrane Hyaluronic Acid Hydrogel Accelerates Full-Thickness Wound Healing. Stem Cells Transl. Med. 6, 2020–2032.

Najjar SA, Smith AST, Long CJ, McAleer CW, Cai Y, Srinivasan B, Martin C, Vandenburgh HH & Hickman JJ (2020) A multiplexed in vitro assay system for evaluating human skeletal muscle functionality in response to drug treatment. Biotechnol. Bioeng. 117, 736–747.

Nam K-H, Smith AST, Lone S, Kwon S & Kim D-H (2015) Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening. J. Lab. Autom. 20, 201–215.

Natarajan A, Smith AST, Berry B, Lambert S, Molnar P & Hickman JJ (2018) Temporal characterization of neuronal migration behavior on chemically patterned neuronal circuits in a defined in vitro environment. ACS Biomater. Sci. Eng. 4, 3460–3470.

Oleaga C, Bernabini C, Smith AST, Srinivasan B, Jackson M, McLamb W, Platt V, Bridges R, Cai Y, Santhanam N, Berry B, Najjar S, Akanda N, Guo X, Martin C, Ekman G, Esch MB, Langer J, Ouedraogo G, Cotovio J, Breton L, Shuler ML & Hickman JJ (2016) Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs. Sci. Rep. 6, 20030.

Padilla-Nash HM, Hathcock K, McNeil NE, Mack D, Hoeppner D, Ravin R, Knutsen T, Yonescu R, Wangsa D, Dorritie K, Barenboim L, Hu Y & Ried T (2012) Spontaneous transformation of murine epithelial cells requires the early acquisition of specific chromosomal aneuploidies and genomic imbalances. Genes Chromosomes Cancer 51, 353–374.

Padilla-Nash HM, McNeil NE, Yi M, Nguyen Q-T, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ & Ried T (2013) Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells. Carcinogenesis 34, 1929–1939.

Patterson SL, Grady MS & Bothwell M (1993) Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in cerebrospinal fluid of brain injured human patients. Brain Res. 605, 43–49.

Patterson SL, Grover LM, Schwartzkroin PA & Bothwell M (1992) Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9, 1081–1088.

Peale FV, Mason K, Hunter AW & Bothwell M (1998) Multiplex display polymerase chain reaction amplifies and resolves related sequences sharing a single moderately conserved domain. Anal. Biochem. 256, 158–168.

Peale FV, Sugden L & Bothwell M (1998) Characterization of CMIX, a chicken homeobox gene related to the Xenopus gene mix.1. Mech. Dev. 75, 167–170.

Pioner JM, Guan X, Klaiman JM, Racca AW, Pabon L, Muskheli V, Macadangdang J, Ferrantini C, Hoopmann MR, Moritz RL, Kim D-H, Tesi C, Poggesi C, Murry CE, Childers MK, Mack DL & Regnier M (2020) Absence of full-length dystrophin impairs normal maturation and contraction of cardiomyocytes derived from human-induced pluripotent stem cells. Cardiovasc. Res. 116, 368–382.

Pioner JM, Racca AW, Klaiman JM, Yang K-C, Guan X, Pabon L, Muskheli V, Zaunbrecher R, Macadangdang J, Jeong MY, Mack DL, Childers MK, Kim D-H, Tesi C, Poggesi C, Murry CE & Regnier M (2016) Isolation and Mechanical Measurements of Myofibrils from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cell Reports 6, 885–896.

Pioner JM, Santini L, Palandri C, Martella D, Lupi F, Langione M, Querceto S, Grandinetti B, Balducci V, Benzoni P, Landi S, Barbuti A, Ferrarese Lupi F, Boarino L, Sartiani L, Tesi C, Mack DL, Regnier M, Cerbai E, Parmeggiani C, Poggesi C, Ferrantini C & Coppini R (2019) Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates. Int. J. Mol. Sci. 20.

Pirozzi KL, Long CJ, McAleer CW, Smith AST & Hickman JJ (2013) Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device. Appl. Phys. Lett 103, 83108.

Potter G, Smith AST, Vo NTK, Muster J, Weston W, Bertero A, Maves L, Mack DL & Rostain A (2020) A More Open Approach Is Needed to Develop Cell-Based Fish Technology: It Starts with Zebrafish. One Earth 3, 54–64.

Rebouche CJ & Mack DL (1984) Sodium gradient-stimulated transport of L-carnitine into renal brush border membrane vesicles: kinetics, specificity, and regulation by dietary carnitine. Arch. Biochem. Biophys. 235, 393–402.

Rebouche CJ, Mack DL & Edmonson PF (1984) L-Carnitine dissimilation in the gastrointestinal tract of the rat. Biochemistry 23, 6422–6426.

Rekler D & Kalcheim C (2022) Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling. eLife 11.

Ross AH, Grob P, Bothwell M, Elder DE, Ernst CS, Marano N, Ghrist BF, Slemp CC, Herlyn M & Atkinson B (1984) Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc Natl Acad Sci USA 81, 6681–6685.

Ross AH, Herlyn M, Maul GG, Koprowski H, Bothwell M, Chao M, Pleasure D & Sonnenfeld KH (1986) The nerve growth factor receptor in normal and transformed neural crest cells. Ann. N. Y. Acad. Sci. 486, 115–123.

Ross JA, Tasfaout H, Levy Y, Morgan J, Cowling BS, Laporte J, Zanoteli E, Romero NB, Lowe DA, Jungbluth H, Lawlor MW, Mack DL & Ochala J (2020) rAAV-related therapy fully rescues myonuclear and myofilament function in X-linked myotubular myopathy. Acta Neuropathol. Commun. 8, 167.

Russo L, Sladitschek HL & Neveu PA (2022) Multi-layered regulation of neuroectoderm differentiation by retinoic acid in a primitive streak-like context. Stem Cell Reports 17, 231–244.

Santos PM, Winterowd JG, Allen GG, Bothwell MA & Rubel EW (1991) Nerve growth factor: increased angiogenesis without improved nerve regeneration. Otolaryngol. Head Neck Surg. 105, 12–25.

Schatteman GC, Gibbs L, Lanahan AA, Claude P & Bothwell M (1988) Expression of NGF receptor in the developing and adult primate central nervous system. J. Neurosci. 8, 860–873.

Schatteman GC, Langer T, Lanahan AA & Bothwell MA (1993) Distribution of the 75-kD low-affinity nerve growth factor receptor in the primate peripheral nervous system. Somatosens. Mot. Res. 10, 415–432.

Schechter AL & Bothwell MA (1981) Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell 24, 867–874.

Schecterson LC & Bothwell M (2008) An all-purpose tool for axon guidance. Sci. Signal. 1, pe50.

Schecterson LC & Bothwell M (1994) Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear. Hear. Res. 73, 92–100.

Schecterson LC & Bothwell M (2010) Neurotrophin receptors: Old friends with new partners. Dev. Neurobiol. 70, 332–338.

Schecterson LC & Bothwell M (1992) Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 9, 449–463.

Schecterson LC, Hudson MP, Ko M, Philippidou P, Akmentin W, Wiley J, Rosenblum E, Chao MV, Halegoua S & Bothwell M (2010) Trk activation in the secretory pathway promotes Golgi fragmentation. Mol. Cell. Neurosci. 43, 403–413.

Schecterson LC, Sanchez JT, Rubel EW & Bothwell M (2012) TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis. J. Neurosci. 32, 14000–14009.

Sehgal A, Bothwell M & Chao M (1989) Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts. Nucleic Acids Res. 17, 5623–5632.

Shi Y, Liu G, Wu R, Mack DL, Sun XS, Maxwell J, Guan X, Atala A & Zhang Y (2022) Differentiation Capacity of Human Urine-Derived Stem Cells to Retain Telomerase Activity. Front. Cell Dev. Biol. 10, 890574.

Skardal A, Mack D, Atala A & Soker S (2013) Substrate elasticity controls cell proliferation, surface marker expression and motile phenotype in amniotic fluid-derived stem cells. J. Mech. Behav. Biomed. Mater. 17, 307–316.

Skardal A, Mack D, Kapetanovic E, Atala A, Jackson JD, Yoo J & Soker S (2012) Bioprinted amniotic fluid-derived stem cells accelerate healing of large skin wounds. Stem Cells Transl. Med. 1, 792–802.

Smith AS, Luttrell SM, Dupont J-B, Gray K, Lih D, Fleming JW, Cunningham NJ, Jepson S, Hesson J, Mathieu J, Maves L, Berry BJ, Fisher EC, Sniadecki NJ, Geisse NA & Mack DL (2022) High-throughput, real-time monitoring of engineered skeletal muscle function using magnetic sensing. J. Tissue Eng. 13, 20417314221122130.

Smith AST, Choi E, Gray K, Macadangdang J, Ahn EH, Clark EC, Laflamme MA, Wu JC, Murry CE, Tung L & Kim D-H (2019) NanoMEA: A Tool for High-Throughput, Electrophysiological Phenotyping of Patterned Excitable Cells. Nano Lett.

Smith AST, Chun C, Hesson J, Mathieu J, Valdmanis PN, Mack DL, Choi B-O, Kim D-H & Bothwell M (2021) Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies. Front. Cell Dev. Biol. 9, 728707.

Smith AST, Davis J, Lee G, Mack DL & Kim D-H (2016) Muscular dystrophy in a dish: engineered human skeletal muscle mimetics for disease modeling and drug discovery. Drug Discov. Today 21, 1387–1398.

Smith AST, Kim JH, Chun C, Gharai A, Moon HW, Kim EY, Nam SH, Ha N, Song JY, Chung KW, Doo HM, Hesson J, Mathieu J, Bothwell M, Choi B-O & Kim D-H (2021) HDAC6 Inhibition Corrects Electrophysiological and Axonal Transport Deficits in a Human Stem Cell-Based Model of Charcot-Marie-Tooth Disease (Type 2D). Advanced Biology, e2101308.

Smith AST, Long CJ, Berry BJ, McAleer C, Stancescu M, Molnar P, Miller PG, Esch MB, Prot J-M, Hickman JJ & Shuler ML (2013) Microphysiological systems and low-cost microfluidic platform with analytics. Stem Cell Res. Ther. 4 Suppl 1, S9.

Smith AST, Long CJ, McAleer C, Bobbitt N, Srinivasan B & Hickman JJ (2014) Utilization of microscale silicon cantilevers to assess cellular contractile function in vitro. J. Vis. Exp., e51866.

Smith AST, Long CJ, Pirozzi K & Hickman JJ (2013) A functional system for high-content screening of neuromuscular junctions in vitro. Technology (Singap World Sci) 1, 37–48.

Smith AST, Long CJ, Pirozzi K, Najjar S, McAleer C, Vandenburgh HH & Hickman JJ (2014) A multiplexed chip-based assay system for investigating the functional development of human skeletal myotubes in vitro. J. Biotechnol. 185, 15–18.

Smith AST, Macadangdang J, Leung W, Laflamme MA & Kim D-H (2017) Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening. Biotechnol. Adv. 35, 77–94.

Smith AST, Passey S, Greensmith L, Mudera V & Lewis MP (2012) Characterization and optimization of a simple, repeatable system for the long term in vitro culture of aligned myotubes in 3D. J. Cell. Biochem. 113, 1044–1053.

Smith AST, Passey SL, Martin NRW, Player DJ, Mudera V, Greensmith L & Lewis MP (2016) Creating Interactions between Tissue-Engineered Skeletal Muscle and the Peripheral Nervous System. Cells Tissues Organs (Print) 202, 143–158.

Smith AST, Yoo H, Yi H, Ahn EH, Lee JH, Shao G, Nagornyak E, Laflamme MA, Murry CE & Kim D-H (2017) Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering. Chem. Commun. 53, 7412–7415.

Song X-J, Zhou H-Y, Sun Y-Y & Huang H-C (2021) Phosphorylation and Glycosylation of Amyloid-β Protein Precursor: The Relationship to Trafficking and Cleavage in Alzheimer’s Disease. J Alzheimers Dis.

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Strazdis J, Lanahan A, Johnson DE, Bothwell M & Kucherlapati R (1985) The epidermal growth factor (EGF) receptor gene studied using gene transfer. Int. J. Neurosci. 26, 129–140.

Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH & Salomon DS (2008) Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J. Cell. Physiol. 216, 824–834.

Subramani S, Bothwell MA, Gibbons I, Yang YR & Schachman HK (1977) Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamolylase. Proc Natl Acad Sci USA 74, 3777–3781.

Sung JH, Esch MB, Prot J-M, Long CJ, Smith A, Hickman JJ & Shuler ML (2013) Microfabricated mammalian organ systems and their integration into models of whole animals and humans. Lab Chip 13, 1201–1212.

Taiji M, Taiji K, Deyerle KL & Bothwell M (1992) Basic fibroblast growth factor enhances nerve growth factor receptor gene promoter activity in human neuroblastoma cell line CHP100. Mol. Cell. Biol. 12, 2193–2202.

Tesar PJ, Chenoweth JG, Brook FA, Davies TJ, Evans EP, Mack DL, Gardner RL & McKay RDG (2007) New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196–199.

Thompson SJ, Schatteman GC, Gown AM & Bothwell M (1989) A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. Am. J. Clin. Pathol. 92, 415–423.

Topcu Z, Mack DL, Hromas RA & Borden KL (1999) The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control. Oncogene 18, 7091–7100.

Tsui JH, Leonard A, Camp ND, Long JT, Nawas ZY, Chavanachat R, Smith AST, Choi JS, Dong Z, Ahn EH, Wolf-Yadlin A, Murry CE, Sniadecki NJ & Kim D-H (2021) Tunable electroconductive decellularized extracellular matrix hydrogels for engineering human cardiac microphysiological systems. Biomaterials 272, 120764.

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Vickland H, Westrum LE, Kott JN, Patterson SL & Bothwell MA (1991) Nerve growth factor receptor expression in the young and adult rat olfactory system. Brain Res. 565, 269–279.

Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PIH, Verveer PJ, Carter BD & Ibáñez CF (2009) Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron 62, 72–83.

Wagner M, Han B & Jessell TM (1992) Regional differences in retinoid release from embryonic neural tissue detected by an in vitro reporter assay. Development 116, 55–66.

Walker SJ, Wagoner AL, Leavitt D & Mack DL (2021) A simplified approach for derivation of induced pluripotent stem cells from Epstein-Barr virus immortalized B-lymphoblastoid cell lines. Heliyon 7, e06617.

Wang Y, Sakano H, Beebe K, Brown MR, de Laat R, Bothwell M, Kulesza RJ & Rubel EW (2014) Intense and specialized dendritic localization of the fragile X mental retardation protein in binaural brainstem neurons: a comparative study in the alligator, chicken, gerbil, and human. J. Comp. Neurol. 522, 2107–2128.

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Wiley JC, Hudson M, Kanning KC, Schecterson LC & Bothwell M (2005) Familial Alzheimer’s disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. J. Neurochem. 94, 1189–1201.

Wiley JC, Meabon JS, Frankowski H, Smith EA, Schecterson LC, Bothwell M & Ladiges WC (2010) Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. PLoS ONE 5, e9135.

Wiley JC, Smith EA, Hudson MP, Ladiges WC & Bothwell M (2007) Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain. J. Biol. Chem. 282, 33313–33325.

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