{"id":941,"date":"2021-12-23T17:26:42","date_gmt":"2021-12-24T01:26:42","guid":{"rendered":"https:\/\/depts.washington.edu\/eph\/wordpress\/?page_id=941"},"modified":"2021-12-23T17:26:42","modified_gmt":"2021-12-24T01:26:42","slug":"cultured-duchenne-muscular-dystrophy-myocytes-as-a-drug-screening-platform","status":"publish","type":"page","link":"https:\/\/depts.washington.edu\/eph\/wordpress\/cultured-duchenne-muscular-dystrophy-myocytes-as-a-drug-screening-platform\/","title":{"rendered":"Cultured Duchenne muscular dystrophy myocytes as a drug screening platform"},"content":{"rendered":"\n
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Cardiomyopathy in DMD<\/figcaption><\/figure><\/div>\n\n\n\n

Symptoms of DMD include cardiomyopathy. Previous work has shown that several cardiac symptoms of DMD can be traced to calcium handling defects. A preliminary drug screen by our lab identified several L-type Calcium Channel blockers (CCBs) that were able to provide a cardioprotective effect. To conclusively determine the effectiveness of these CCBs, we use iPSC-derived cardiomyocytes in a high-throughput drug screening platform that can accurately replicate physiological cardiomyocytes and screen these CCBs for potential drug therapies. This project will culminate in the development of a novel and cost-effective platform that offers superior prediction of drug efficacy for DMD and potentially other cardiomyopathies as well.<\/p>\n\n\n\n

Lead investigator: Naveen Arunachalam Sakthiyendran<\/a><\/strong> <\/p>\n\n\n\n

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Mature cardiomyoctes – phase contrast image<\/figcaption><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"

Symptoms of DMD include cardiomyopathy. Previous work has shown that several cardiac symptoms of DMD can be traced to calcium handling defects. A preliminary drug screen by our lab identified several L-type Calcium Channel blockers (CCBs) that were able to provide a cardioprotective effect. To conclusively determine the effectiveness of these CCBs, we use iPSC-derived […]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-941","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/pages\/941","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/comments?post=941"}],"version-history":[{"count":1,"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/pages\/941\/revisions"}],"predecessor-version":[{"id":945,"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/pages\/941\/revisions\/945"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/eph\/wordpress\/wp-json\/wp\/v2\/media?parent=941"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}