Nicole F. Liachko, Ph.D.
Research Assistant Professor
Research Interest: Dr. Liachko is a molecular geneticist committed to improving the lives of those afflicted by amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating neurodegenerative diseases of aging. Her goals are to understand the molecular mechanisms driving these diseases and to develop potential therapeutic interventions targeting them. To accomplish this, the Liachko lab works with models of ALS and FTLD-TDP including mouse primary neurons, mammalian cultured cells, and the nematode C. elegans to identify molecular changes that promote disease and test whether interventions in these processes provide neuroprotection.
Aggregates of highly phosphorylated TDP-43 protein in disease-affected neurons are the pathological hallmark of ALS and FTLD-TDP. The Liachko lab is studying cellular pathways promoting or clearing phosphorylated TDP-43, particularly focused on the kinase CDC7 and the phosphatase calcineurin. Ongoing work includes identifying contributors to TDP-43 neurotoxicity, mapping out the mechanisms controlling pathological TDP-43 phosphorylation, and identifying novel therapeutic targets to treat FTLD-TDP and other TDP-43 proteinopathies.
Education and Training:
College: 2001, Brandeis University, Waltham, MA
Graduate School: 2009, Ph.D., Genetics, Cornell University, Ithaca, NY
Postdoctoral Training: 2009-2011, Department of Pathology, University of Washington,
VA Career Development Program (CDA1): 2011-2013, VA Puget Sound Health Care System/University of Washington, Seattle, WA
Bibliography: Link to NCBI Collections
Seattle VA Puget Sound Health Care System
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Seattle WA 98108
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