{"id":17469,"date":"2024-08-29T13:45:30","date_gmt":"2024-08-29T20:45:30","guid":{"rendered":"https:\/\/depts.washington.edu\/globalwach\/?p=17469"},"modified":"2026-04-07T14:13:58","modified_gmt":"2026-04-07T21:13:58","slug":"new-study-aims-to-evaluate-a-novel-pediatric-tb-diagnostic-tool-and-treatment-response","status":"publish","type":"post","link":"https:\/\/depts.washington.edu\/globalwach\/2024\/08\/29\/new-study-aims-to-evaluate-a-novel-pediatric-tb-diagnostic-tool-and-treatment-response\/","title":{"rendered":"New study aims to evaluate a novel pediatric TB diagnostic tool and treatment response"},"content":{"rendered":"

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Investigators Dr. Sylva LaCourse (UW), Dr. Tony Hu (Tulane University), and Dr. Vidalis Nduba (KEMRI CRDR)<\/em><\/span><\/p>\n<\/div>\n

Young children account for 50% of pediatric tuberculosis (TB) cases but are least likely to be diagnosed and are at the highest risk of death without prompt treatment. Current available diagnostics \u2013 typically sputum-based \u2013 often fail to identify TB in children and are generally not reliable for measuring treatment response. There is a need to develop and evaluate novel diagnostic tools utilizing blood and urine, which may identify pediatric TB missed by respiratory sampling.<\/p>\n

A new five-year study titled \u201cCRISPR-TB for pediatric TB diagnosis and treatment response\u201d<\/strong> funded by the National Institutes of Health will support an evaluation of a CRISPR-based technology to target and detect Mycobacterium tuberculosis cell-free DNA (cfDNA). The study\u2019s findings may provide a deeper understanding of its potential to diagnosis pediatric TB early and accurately and improve treatment responses.<\/p>\n

The study team includes Principal Investigator Dr. Sylvia LaCourse (Associate Professor, UW Global Health and Medicine-Allergy and Infectious Diseases)<\/strong>, <\/strong>Jaclyn Escudero (Research Coordinator with Global WACh),<\/strong> and Co-Investigators <\/strong>Dr. Tony Hu (Tulane University),<\/strong> Dr. Videlis Nduba (Kenya Medical Research Institute Centre for Respiratory Diseases Research (KEMRI CRDR)<\/strong>,<\/strong> with support from their respective research teams.<\/p>\n

The study leverages an existing collaboration between KEMRI CRDR who leads the clinical cohorts, while the Hu Lab will lead the CRISPR-TB platform optimization and testing of samples. The UW GWACh team led by Dr. LaCourse will provide oversight for the study design, execution, and analysis.<\/p>\n

Congratulations to the team for receiving this award and we look forward to sharing updates on the study\u2019s progress!<\/p>\n","protected":false},"excerpt":{"rendered":"

  Young children account for 50% of pediatric tuberculosis (TB) cases but are least likely to be diagnosed and are at the highest risk of death without prompt treatment. Current available diagnostics \u2013 typically sputum-based \u2013 often fail to identify TB in children and are generally not reliable for measuring treatment response. There is a…<\/p>\n

Read more<\/a><\/div>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[40,89,16],"tags":[],"class_list":["post-17469","post","type-post","status-publish","format-standard","hentry","category-awards","category-hiv-and-co-infections","category-research"],"_links":{"self":[{"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/posts\/17469","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/comments?post=17469"}],"version-history":[{"count":6,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/posts\/17469\/revisions"}],"predecessor-version":[{"id":18952,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/posts\/17469\/revisions\/18952"}],"wp:attachment":[{"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/media?parent=17469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/categories?post=17469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/depts.washington.edu\/globalwach\/wp-json\/wp\/v2\/tags?post=17469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}