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School of Public Health
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Larry Kessler

faculty photo
Professor, Health Services
Adjunct Professor, Pharmacy


Education

ScD   Johns Hopkins University, 1978   (Health Services Admin)
BS   Boston University, 1973   (Mathematics)

Contact Info

email:   kesslerl@uw.edu

office:   F-351E, Health Sciences Building

address:
University of Washington
Department of Health Services
Seattle, WA 98195-3660

campus box:   357660
voice:   206-543-2703

About

Larry Kessler is a former Chair of the Department of Health Services. He served as Director of the Office of Surveillance and Biometrics, Center for Devices and Radiological Health, FDA until 2008. From 1984 to 1995, he headed and developed the Applied Research Branch at NCI. In 2001, he spent a year as a visiting scientist at the Fred Hutchinson Cancer Research Center and served on the faculty of the Department of Health Services.


Cost-effectiveness and diagnostic value of medical technology in screening for cancer and other diseases
  • HSERV 512
    Health Systems and Policy
  • HSERV 578
    Preparing, Writing, and Critiquing Scientific Research Proposals


Friedly JL, Comstock BA, Turner JA, Heagerty PJ, Deyo RA, Bauer Z, Avins AL, Nedeljkovic SS, Nerenz DR, Shi XR, Annaswamy T, Standaert CJ, Smuck M, Kennedy DJ, Akuthota V, Sibell D, Wasan AD, Diehn F, Suri P, Rundell SD, Kessler L, Chen AS, Jarvik JG. Long-Term Effects of Repeated Injections of Local Anesthetic With or Without Corticosteroid for Lumbar Spinal Stenosis: A Randomized Trial. Arch Phys Med Rehabil. 2017 Aug;98(8):1499-1507.e2. doi: 10.1016/j.apmr.2017.02.029. Epub 2017 Apr 8.  PMID: 28396242
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DOI
 


Agapova M, Bresnahan BW, Linnau KF, Garrison LP Jr, Higashi M, Kessler L, Devine B. Toward a Framework for Benefit-Risk Assessment in Diagnostic Imaging: Identifying Scenario-specific Criteria. Acad Radiol. 2017 May;24(5):538-549. doi: 10.1016/j.acra.2017.02.002. Epub 2017 Mar 31.  PMID: 28372958
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DOI
 


Agapova M, Bresnahan BW, Linnau KF, Garrison LP Jr, Higashi M, Kessler L, Devine B. Using the Analytic Hierarchy Process for Prioritizing Imaging Tests in Diagnosis of Suspected Appendicitis. Acad Radiol. 2017 May;24(5):530-537. doi: 10.1016/j.acra.2017.01.001. Epub 2017 Mar 28.  PMID: 28363670
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Agapova M, Bresnahan BB, Higashi M, Kessler L, Garrison LP Jr, Devine B. A proposed approach for quantitative benefit-risk assessment in diagnostic radiology guideline development: the American College of Radiology Appropriateness Criteria Example. J Eval Clin Pract. 2016 Oct 19. doi: 10.1111/jep.12635. [Epub ahead of print]  PMID: 27762080
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Rundell SD, Goode AP, Suri P, Heagerty PJ, Comstock BA, Friedly JL, Gold LS, Bauer Z, Avins AL, Nedeljkovic SS, Nerenz DR, Kessler L, Jarvik JG. Effect of Comorbid Knee and Hip Osteoarthritis on Longitudinal Clinical and Health Care Use Outcomes in Older Adults With New Visits for Back Pain. Arch Phys Med Rehabil. 2017 Jan;98(1):43-50. doi: 10.1016/j.apmr.2016.06.022.  PMID: 27519927
PubMed
 
DOI
 


Cost Effectiveness Analysis and Comparative Effectiveness Research Component of STOP 2
Cystic Fibrosis Foundation Therapeutics, Inc.
PI:   Kessler           Dates:    7/1/2017 - 6/30/2018

Institute of Translational Health Sciences
National Center for Advancing Translational Sciences (NCATS)
PI:   Disis           Dates:    6/1/2017 - 5/31/2022

Translational Research Center to Expedite Novel Therapies in Cystic Fibrosis
Seattle Children's Hospital Research Institute
PI:   Greenberg           Dates:    6/1/2017 - 5/31/2018

Practice Patterns and Impact of Operative and Non-operative Management of Diverticulitis
National Institutes of Health (NIH)
PI:   Flum           Dates:    5/1/2017 - 4/30/2018

NKC - UW Center for Dialysis Innovation Grant
Northwest Kidney Centers (NKC)
PI:   Himmelfarb           Dates:    3/1/2017 - 7/31/2021

A new Nanotechnology Therapy for Glioblastoma and Prostate Cancer
MagForce USA, Inc.
PI:   Kessler           Dates:    2/1/2017 - 1/31/2018

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
PI:   Jarvik           Dates:    1/1/2017 - 12/31/2017

Cost Effectiveness Analysis and Comparative Effectiveness Research Component of STOP 2
Cystic Fibrosis Foundation Therapeutics, Inc.
PI:   Kessler           Dates:    7/1/2016 - 12/31/2019

Translational Research Center to Expedite Novel Therapies in Cystic Fibrosis
Seattle Children's Hospital Research Institute
PI:   Greenberg           Dates:    6/1/2016 - 5/31/2017

Institute of Translational Health Sciences (ITHS)
National Center for Advancing Translational Sciences (NCATS)
PI:   Disis           Dates:    6/1/2016 - 5/31/2017

Practice Patterns and Impact of Operative and Non-operative Management of Diverticulitis
National Institutes of Health (NIH)
PI:   Flum           Dates:    5/1/2016 - 4/30/2017

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
PI:   Jarvik           Dates:    1/1/2016 - 12/31/2016

Comparing Outcomes of Drugs and Appendectomy (CODA)
Patient-Centered Outcomes Research Institute (PCORI)
PI:   Flum           Dates:    10/1/2015 - 9/30/2020

Practice Patterns and Impact of Operative and Non-operative Management of Diverticulitis
National Institutes of Health (NIH)
PI:   Flum           Dates:    7/1/2015 - 6/30/2020

Topical Antibiotic Treatment for Spine Surgical Site Infections
National Institutes of Health (NIH)
PI:   Flum           Dates:    7/1/2015 - 6/30/2017

Institute of Translational Health Sciences (ITHS)
National Center for Advancing Translational Sciences (NCATS)
PI:   Disis           Dates:    6/1/2015 - 5/31/2016

Translational Research Center to Expedite Novel Therapies in Cystic Fibrosis
Seattle Children's Hospital Research Institute
PI:   Greenberg           Dates:    6/1/2015 - 5/31/2020

A new Nanotechnology Therapy for Glioblastoma and Prostate Cancer
MagForce USA, Inc.
PI:   Kessler           Dates:    3/1/2015 - 12/31/2015

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
National Institutes of Health (NIH)
PI:   Jarvik           Dates:    1/1/2015 - 12/31/2015

A new Nanotechnology Therapy for Glioblastoma and Prostate Cancer
MagForce USA, Inc.
PI:   Kessler           Dates:    10/1/2014 - 6/30/2015

VA Services agreement 2014 - 15
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    9/1/2014 - 8/31/2015

VA Services Agreement 2014 - 15 - Supplement
VA Puget Sound Health Care System (VAPSHCS)
PI:   Kessler           Dates:    9/1/2014 - 8/31/2015

Cancer Consortium Non-Competing Renewal 2014
Fred Hutchinson Cancer Research Center (FHCRC)
PI:   Bremner           Dates:    1/1/2014 - 12/31/2014

A Pragmatic Trial of Lumbar Image Reporting with Epidemiology (LIRE)
National Center for Complementary and Alternative Medicine (NCCAM)
PI:   Jarvik           Dates:    1/1/2014 - 12/31/2017

LSDF SCOAP CER Network
Washington State Life Sciences Discovery Fund Authority (LSDFA)
PI:   Flum           Dates:    10/16/2013 - 10/15/2015

Long Term Outcomes of Lumbar Epidural Steroid Injections for Spinal Stenosis
Patient-Centered Outcomes Research Institute (PCORI)
PI:   Friedly           Dates:    5/1/2013 - 4/30/2016

Comparative Effectiveness of Dynamic Patterns of Glucose Lowering Therapies
University of Chicago
PI:   Kessler           Dates:    7/1/2011 - 6/30/2015

National Emphysema Treatment Trial

Collaborating on a cost-effectiveness study of a very controversial surgical treatment for emphysema patients.


CanCORS

Collaborating on studies of outcomes and patterns of care of both colorectal cancer and lung cancer. We are looking into what kinds of treatment certain types of patients receive and how we can improve the process of obtaining the best cancer care.


CISNET

Collaborating on a study focused on the tremendous increase in the rate of prostate cancer incidence during the 1990's. Much of this disease may represent 'overdiagnosis' which is accompanied by significant loss of quality of life in many cases.