In the new study reported this week, the UW Medicine-led research team used human brain cells created from stem cells. The results showed that a compound that boosts the function of the endosomal network significantly cuts the production of both amyloid beta and a precursor of the Tau protein. The study will be published online March 1st in the journal Stem Cell Reports.

The lead author is Jessica Young, assistant professor of pathology at the UW School of Medicine in Seattle. 

She noted that the findings suggest that targeting defects in the endosomal network, through the discovery of drugs or other therapeutics, such as gene therapy, may be a promising strategy against Alzheimer's disease.

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