Institute for Stem Cell & Regenerative Medicine

at the University of Washington

Recent Research

Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways
Human Molecular Genetics, October 2015


Heterogeneity of epigenetic changes at ischemia/reperfusion- and endotoxin-induced acute kidney injury genes
Kidney International, October 2015


Mechanisms and clinical applications of chromosomal instability in lymphoid malignancy
British Journal of Haematology, October 15


MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages
Journal of Investigative Dermatology, October 2015


Adeno-associated virus finds its disease
Nature Genetics, September 2015


Comprehensive identification and analysis of human accelerated regulatory DNA
Genome Research, September 2015


Defined MicroRNAs Induce Aspects of Maturation in Mouse and Human Embryonic-Stem-Cell-Derived Cardiomyocytes
Cell Reports, September 2015


Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes
Development, September 2015


It's never too late to save a photoreceptor
The Journal of Clinical Investigation, September 2015


Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs
Cell Host & Microbe, September 2015


Syngeneic myoblast transplantation improves muscle function in a murine model of X-linked myotubular myopathy
Cell Transplantation, September 2015


The advancement of human pluripotent stem cell-derived therapies into the clinic
Development, September 2015


The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells
Stem Cells, September 2015


Use of Adeno-Associated Virus to Enrich Cardiomyocytes Derived from Human Stem Cells
Human Gene Therapy Clinical Development, September 2015


A phase I/II study of oral clofarabine plus low-dose cytarabine in previously treated acute myeloid leukaemia and high-risk myelodysplastic syndrome patients at least 60 years of age
British Journal of Haematology, August 2015

A Quantitative Proteomic Analysis of Hemogenic Endothelium Reveals Differential Regulation of Hematopoiesis by SOX17
Stem Cell Reports, August 2015


Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients
American Journal of Clinical Pathology, August 2015

Allogeneic Precursor Cells for Systolic Heart Failure: A Need for Mechanisms in Humans
Circulation Research, August 2015


Dynamic Proteome Response of Pseudomonas aeruginosa to Tobramycin Antibiotic Treatment
Molecular & Cellular Proteomics, August 2015


Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity
Journal of Lipid Research, August 2015


JAK/STAT Pathway Inhibitors and Neurologic Toxicity: Above All Else Do No Harm?
JAMA Oncology, August 2015


Mitochondrion as a Target for Heart Failure Therapy - Role of Protein Lysine Acetylation
Circulation Journal, August 2015


MMTV/LTR Promoter-Driven Transgenic Expression of EpCAM Leads to the Development of Large Pancreatic Islets
Journal of Histochemistry & Cytochemistry, August 2015


Outcomes in Reoperated Low-Grade Gliomas
Neurosurgery, August 2015


Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells
The Journal of Clinical Investigation, August 2015


Quantitative interactome analysis reveals a chemoresistant edgotype
Nature Communications, August 2015

Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
European Journal of Heart Failure, August 2015

Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation
PLOS ONE, August 2015