Institute for Stem Cell & Regenerative Medicine

at the University of Washington

Recent Research

O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
BBA Clinical, June 2015

G-CSF Priming, clofarabine, and high dose cytarabine (GCLAC) for upfront treatment of acute myeloid leukemia, advanced myelodysplastic syndrome or advanced myeloproliferative neoplasm
                 American Journal of Hematology, April 2015

JALA Special Issue: Microengineered Cell- and Tissue-Based Assays for Drug Screening and Toxicology Applications
Journal of Laboratory Automation, April 2015


Phosphorylation of Ser283 enhances the stiffness of the tropomyosin head-to-tail overlap domain
Archives of Biochemistry and Biophysics, April 2015


Cadherins in Islet β-Cells: More Than Meets the Eye
Diabetes, March 2015


Combined effects of substrate topography and stiffness on endothelial cytokine and chemokine secretion
ACS Applied Materials & Interfaces, March 2015


Correlation between peripheral blood and bone marrow regarding FLT3-ITD and NPM1 mutational status in patients with acute myeloid leukemia
Haematologica, March 2015


Epigenomics of autoimmune diseases
Immunology & Cell Biology, March 2015


Exposure to phthalates affects calcium handling and intercellular connectivity of human stem cell-derived cardiomyocytes
PLOS ONE, March 2015

LINGO-1 promotes lysosomal degradation of amyloid-β protein
                 Pathobiology of Aging & Age-related Diseases, March 2015


Serum amyloid A and inflammation in diabetic kidney disease and podocytes
Laboratory Investigation, March 2015


Small HDL Promotes Cholesterol Efflux by the ABCA1 Pathway in Macrophages: Implications for Therapies Targeted to HDL
Circulation Research, March 2015


2-Deoxy adenosine triphosphate improves contraction in human end-stage heart failure
Journal of Molecular and Cellular Cardiology, February 2015


Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the monaciano symposium
Investigative Ophthalmology & Visual Science, February 2015


A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor
Blood, February 2015

Analysis of the Campylobacter jejuni Genome by SMRT DNA Sequencing Identifies Restriction-Modification Motifs
PLOS ONE, February 2015

A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation
Development, February 2015


Basic mechanisms for adverse cardiovascular events associated with air pollution
Heart, February 2015


Factors associated with the improvement of vocal fold movement: An analysis of LEMG and laryngeal CT parameters
Journal of Electromyography and Kinesiology, February 2015


Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
Nature Genetics, February 2015

Guiding intramuscular diaphragm injections using real-time ultrasound and electromyography
Muscle & Nerve, February 2015


Integrative analysis of 111 reference human epigenomes
Nature, February 2015


Inter-individual differences in CpG methylation at D4Z4 correlate with clinical variability in FSHD1 and FSHD2
Human Molecular Genetics, February 2015


Mitochondrial morphology differences and mitophagy deficit in murine glaucomatous optic nerve
Investigative Ophthalmology & Visual Science, February 2015


PROMISE: Parallel-imaging and compressed-sensing reconstruction of multicontrast imaging using sharable information
Magnetic Resonance in Medicine, February 2015

Sparse expression bases in cancer reveal tumor drivers
Nucleic Acids Research, February 2015


The voices of the embryo donors
Trends in Molecular Medicine, February 2015


Adeno-associated virus-mediated cancer gene therapy: Current status
Cancer Letters, January 2015


Carotid magnetic resonance imaging for monitoring atherosclerotic plaque progression: a multicenter reproducibility study
International Journal of Cardiovascular Imaging, January 2015

Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations
Biophysical Journal, January 2015


Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes
Nature Methods, January 2015


Impaired arteriogenesis in syndecan-1(-/-) mice
Journal of Surgical Research, January 2015


Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics
Journal of Proteomics, January 2015

Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase
Molecular and Cellular Biology, January 2015