Institute for Stem Cell & Regenerative Medicine

at the University of Washington

Recent Research

A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects
Journal of Proteome Research, July 2015


Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro
The EMBO Journal, July 2015


Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia
Haematologica, July 2015

Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation
Developmental Biology, July 2015

Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors
Stem Cells, July 2015


Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity
Stem Cells, July 2015


The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages
The Journal of Immunology, July 2015


A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties
Journal of Controlled Release, June 2015

Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening
Journal of Laboratory Automation, June 2015


Cardiac regeneration validated
Nature Biotechnology, June 2015


Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
Nature Biotechnology, June 2015


Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion
The Journal of Biological Chemistry, June 2015


Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency
Biomaterials, June 2015


Idarubicin, cytarabine, and pravastatin as induction therapy for untreated acute myeloid leukemia and high-risk myelodysplastic syndrome
American Journal of Hematology, June 2015

Interventional MRI-guided local delivery of agents into swine bile duct walls using MR-compatible needle-integrated balloon catheter system
NMR in Biomedicine, June 2015

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Nature, June 2015


Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes
Stroke, June 2015


O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
BBA Clinical, June 2015

Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks
PLOS Computational Biology, June 2015

Seeking Culprit Lesions in Cryptogenic Stroke: The Utility of Vessel Wall Imaging
Journal of the American Heart Association, June 2015


The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle
Human Molecular Genetics, June 2015

Validity of a Neurological Scoring System for Canine X-Linked Myotubular Myopathy
Human Gene Therapy Clinical Development, June 2015


A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels
Nature Materials, May 2015


Ascending KLFs in cardiovascular biology
Trends in Cardiovascular Medicine, May 2015


Cardiac Development in Zebrafish and Human Embryonic Stem Cells Is Inhibited by Exposure to Tobacco Cigarettes and E-Cigarettes
PLOS ONE, May 2015


Dual energy computed tomography quantification of carotid plaques calcification: comparison between monochromatic and polychromatic energies with pathology correlation
European Radiology, May 2015

Endothelium and NOTCH specify and amplify aorta-gonad-mesonephros-derived hematopoietic stem cells
The Journal of Clinical Investigation, May 2015


Identification of a prg4-expressing articular cartilage progenitor cell population in mice
Arthritis & Rheumatology, May 2015


Let-7 family of microRNA is required for maturation and adult-like metabolism in stem cell-derived cardiomyocytes
PNAS, May 2015


Multivalent display of pendant pro-apoptotic peptides increases cytotoxic activity
Journal of Controlled Release, May 2015


Outcomes after stent graft therapy for dissection-related aneurysmal degeneration in the descending thoracic aorta
Journal of Vascular Surgery, May 2015


The winding road to regenerating the human heart
Cardiovascular Pathology, May-June 2015


Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster
                 Nature Communications, May 2015