Institute for Stem Cell & Regenerative Medicine

at the University of Washington

Recent Research

A phase I/II study of oral clofarabine plus low-dose cytarabine in previously treated acute myeloid leukaemia and high-risk myelodysplastic syndrome patients at least 60 years of age
British Journal of Haematology, August 2015

Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients
American Journal of Clinical Pathology, August 2015

Dynamic Proteome Response of Pseudomonas aeruginosa to Tobramycin Antibiotic Treatment
Molecular & Cellular Proteomics, August 2015


Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity
Journal of Lipid Research, August 2015


MMTV/LTR Promoter-Driven Transgenic Expression of EpCAM Leads to the Development of Large Pancreatic Islets
Journal of Histochemistry & Cytochemistry, August 2015


Outcomes in Reoperated Low-Grade Gliomas
Neurosurgery, August 2015


Pathogenesis of ELANE-mutant severe neutropenia revealed by induced pluripotent stem cells
The Journal of Clinical Investigation, August 2015


Quantitative interactome analysis reveals a chemoresistant edgotype
Nature Communications, August 2015

Ribonucleotide reductase-mediated increase in dATP improves cardiac performance via myosin activation in a large animal model of heart failure
European Journal of Heart Failure, August 2015

Temporal Dissection of Rate Limiting Transcriptional Events Using Pol II ChIP and RNA Analysis of Adrenergic Stress Gene Activation
PLOS ONE, August 2015


A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects
Journal of Proteome Research, July 2015


Controlled induction of human pancreatic progenitors produces functional beta-like cells in vitro
The EMBO Journal, July 2015


Effect of allogeneic hematopoietic cell transplantation in first complete remission on post-relapse complete remission rate and survival in acute myeloid leukemia
Haematologica, July 2015

Enhanced Electrical Integration of Engineered Human Myocardium via Intramyocardial versus Epicardial Delivery in Infarcted Rat Hearts
PLOS ONE, July 2015

Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation
Developmental Biology, July 2015


Flow-driven assembly of VWF fibres and webs in in vitro microvessels
Nature Communications, July 2015

Mechanical Stress Promotes Maturation of Human Myocardium From Pluripotent Stem Cell-Derived Progenitors
Stem Cells, July 2015


Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity
Stem Cells, July 2015


The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages
The Journal of Immunology, July 2015


A functionalized, injectable hydrogel for localized drug delivery with tunable thermosensitivity: Synthesis and characterization of physical and toxicological properties
Journal of Controlled Release, June 2015

Biomimetic 3D Tissue Models for Advanced High-Throughput Drug Screening
Journal of Laboratory Automation, June 2015


Cardiac regeneration validated
Nature Biotechnology, June 2015


Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
Nature Biotechnology, June 2015


Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion
The Journal of Biological Chemistry, June 2015


Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency
Biomaterials, June 2015


Idarubicin, cytarabine, and pravastatin as induction therapy for untreated acute myeloid leukemia and high-risk myelodysplastic syndrome
American Journal of Hematology, June 2015

Interventional MRI-guided local delivery of agents into swine bile duct walls using MR-compatible needle-integrated balloon catheter system
NMR in Biomedicine, June 2015

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells
Nature, June 2015


Multicontrast high-resolution vessel wall magnetic resonance imaging and its value in differentiating intracranial vasculopathic processes
Stroke, June 2015


O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma
BBA Clinical, June 2015

Revealing Pathway Dynamics in Heart Diseases by Analyzing Multiple Differential Networks
PLOS Computational Biology, June 2015

Seeking Culprit Lesions in Cryptogenic Stroke: The Utility of Vessel Wall Imaging
Journal of the American Heart Association, June 2015


The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle
Human Molecular Genetics, June 2015

Validity of a Neurological Scoring System for Canine X-Linked Myotubular Myopathy
Human Gene Therapy Clinical Development, June 2015